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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:07 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Isoflavone supplement Clear all

Conditions: Prediabetic State
Interventions: GlucoSupreme™ Herbal, Placebo; Dietary Supplement · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 4
States / cities: Baltimore, Maryland • Cincinnati, Ohio

Conditions: Prostate Neoplasm
Interventions: Soy Supplement, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older · Male only
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Fibromyalgia
Interventions: Soy, Placebo; Dietary Supplement · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 76 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Menopause
Interventions: Placebo, S-equol; Dietary Supplement
Lead sponsor: Pharmavite LLC; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 118 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Prostate Cancer
Interventions: Prevastein HC®, Placebo; Dietary Supplement · Other
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 50 Years to 80 Years · Male only
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2007
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Hot Flashes, Prostate Cancer
Interventions: oral soy protein/isoflavones powder, Venlafaxine, Placebo Powder, Placebo Pill; Dietary Supplement · Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 21 Years and older · Male only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 20
States / cities: Newark, Delaware • Chicago, Illinois • Decatur, Illinois + 15 more

Conditions: Asthma
Interventions: Soy Isoflavone; Dietary Supplement
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Food-drug Interaction
Interventions: Trifolium pratense; Dietary Supplement
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 40 Years to 79 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Atherosclerosis
Interventions: 25 gm soy protein supplement, Placebo; Dietary Supplement · Other
Lead sponsor: University of Southern California; Other
Eligibility: 30 Years and older · Female only
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Prostate Cancer
Interventions: soy protein isolate, casein proteins; Dietary Supplement
Lead sponsor: Alliance for Clinical Trials in Oncology; Other
Eligibility: 50 Years and older · Male only
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2006
U.S. locations: 5
States / cities: Washington D.C., District of Columbia • Syracuse, New York • Winston-Salem, North Carolina + 1 more

Conditions: Breast Cancer, Hot Flashes, Hot Flushes
Interventions: soy protein, isoflavones, Tamoxifen, Placebo; Dietary Supplement · Drug · Other
Lead sponsor: Alliance for Clinical Trials in Oncology; Other
Eligibility: 18 Years and older · Female only
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2013
U.S. locations: 14
States / cities: Rockford, Illinois • Elkhart, Indiana • Kokomo, Indiana + 9 more

Conditions: Bladder Cancer
Interventions: Genistein, Sugar pill; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Prostate Cancer
Interventions: Flav-ein capsules, Placebo; Dietary Supplement · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older · Male only
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Recurrent Acute Pancreatitis, Chronic Pancreatitis
Interventions: Soy-tomato juice product, Will include a soy-tomato juice product to be consumed during the 4 week intervention phase. A total of about 12 ounces (administered in two small cans) of the juice will be consumed; Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Prostate Cancer
Interventions: Genistein, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older · Male only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Central Obesity
Interventions: soy supplementation; Dietary Supplement
Lead sponsor: The University of Texas at San Antonio; Other
Eligibility: 45 Years to 60 Years · Female only
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Metabolic Syndrome, Diabetes Mellitus, Non-Insulin-Dependent
Interventions: Randomized pills either containing combination of lycopene and isoflavones (dietary supplements) or Placebo to be taken for 12 weeks, Screening, OGTT, Anthropometrics and Blood pressure, Blood Drawing; Drug · Other
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 18 Years to 75 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 2
States / cities: Galveston, Texas

Conditions: Wheezing
Interventions: Soy Isoflavone Nutritional Supplements; Drug
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 4 Months to 24 Months
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Breast Cancer, Prostate Cancer
Interventions: Soy Isoflavone Nutritional Supplements; Drug
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: Not listed
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2005
U.S. locations: 1
States / cities: Stanford, California

Conditions: BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
Interventions: soy isoflavones, placebo, questionnaire administration, magnetic resonance imaging, biopsy, immunohistochemistry staining method, laboratory biomarker analysis, mammography; Dietary Supplement · Other · Procedure
Lead sponsor: University of Southern California; Other
Eligibility: 30 Years to 75 Years · Female only
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Migraine Headache
Interventions: Soy Isoflavones; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: Female only
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depression
Interventions: Novasoy; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Menopausal Symptoms
Interventions: Isoflavone supplement; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 38 Years to 65 Years · Female only
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Wheezing, Asthma in Children
Interventions: Soy isoflavone, matching placebo; Drug
Lead sponsor: Rajesh Kumar; Other
Eligibility: 2 Months to 12 Months
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois

Search by objective public record fields.

RCT of a Polyherbal Dietary Supplement for Prediabetes

Role of Soy Supplementation in Prostate Cancer Development

Effect of Revival Soy on Fibromyalgia Pain

A Nutritional Supplement on Vasomotor Symptoms in Women

The Specific Role of Isoflavones in Reducing Prostate Cancer Risk

Soy Protein/Effexor Hormone Therapy for Prostate Cancer

Modification of Asthma With Soy Isoflavone

Red Clover Botanical Dietary Supplements - Metabolism and Safety in Women

Women's Isoflavone Soy Health (WISH) Trial

Soy Protein Supplement in Preventing Prostate Cancer in Patients With Elevated Prostate-Specific Antigen Levels

Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease

Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment

Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy

Soy Tomato Juice to Improve Outcomes in Pancreatitis

Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer

Soy as an Innovative Dietary Component in Abdominal Obesity Management Amongst Peri- and Early Menopausal Women

Effect of Lycopene and Isoflavones on Glucose Metabolism

Genes, Soy Isoflavones, and Virus

Effects of Soy Compounds on Breast Cancer, Prostate Cancer, and Bone Health

Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer

Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache

Examination of a Soy-Based Supplement for Major Depression

Effects of Soy Isoflavones on Menopausal Hot Flashes

Soy Isoflavones For Inner City Infants At Risk For Asthma (SIRA) Study