Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 13, 2026, 1:13 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 697–720 of 1,141 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Isotonic solution Clear all

Conditions: Acute Hypovolemia
Interventions: Volume resuscitation (Crystalloid), Volume resuscitation (Hypertonic Saline Solution); Other
Lead sponsor: University of California, Davis; Other
Eligibility: 17 Years to 70 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Cervical Spondylosis, Lumbar Spondylosis
Interventions: Ibuprofen, normal saline; Drug · Other
Lead sponsor: St. Joseph's Hospital and Medical Center, Phoenix; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Liver Cirrhosis, Acute Kidney Injury, Hepatorenal Syndrome
Interventions: Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy; Combination Product
Lead sponsor: Azienda Ospedaliera di Padova; Other
Eligibility: 18 Years and older
Enrollment: 1,456 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 5
States / cities: Indianapolis, Indiana • New Orleans, Louisiana • Boston, Massachusetts + 2 more

Conditions: Aging
Interventions: Esmolol infusion, Saline infusion, Pre exercise baseline, Isometric handgrip exercise, Semi-recumbent cycling; Drug · Other
Lead sponsor: David N. Proctor, PhD; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Corneal Abrasion
Interventions: Ophthalmic Tetracaine, Normal Saline; Drug · Other
Lead sponsor: New York Presbyterian Brooklyn Methodist Hospital; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: New-onset Type 1 Diabetes Mellitus
Interventions: Antithymocyte globulin, Placebo; Drug
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 12 Years to 35 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 9
States / cities: Los Angeles, California • Oakland, California • San Diego, California + 6 more

Conditions: Malaria, Malaria,Falciparum
Interventions: PfSPZ Vaccine, PfSPZ Challenge (7G8), Normal Saline; Biological · Other
Lead sponsor: Sanaria Inc.; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pain, Sickle Cell Disorder
Interventions: Normal saline, Ketamine; Drug
Lead sponsor: Billy Sin; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Infertility of Uterine Origin
Interventions: AMD3100, Normal saline, dilation and curettage; Drug · Procedure
Lead sponsor: Reproductive Medicine Associates of New Jersey; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 3
States / cities: San Francisco, California • Basking Ridge, New Jersey • Philadelphia, Pennsylvania

Conditions: Degenerative Disc Disease
Interventions: Tranexamic Acid, Saline Solution, Visual Acuity Exam, 3 Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM); Drug · Diagnostic Test
Lead sponsor: Catherine R. Olinger; Other
Eligibility: 18 Years to 90 Years
Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Osteoarthritis
Interventions: Povidone iodine, Vancomycin powder, Conventional; Drug · Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 2,129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 14
States / cities: Rancho Mirage, California • Denver, Colorado • Weston, Florida + 6 more

Conditions: Subarachnoid Hemorrhage, Acute Kidney Injury
Interventions: Sodium chloride /sodium acetate (16.4%), Sodium chloride (23.4%), PlasmaLyte; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Lung Neoplasms, Respiratory Failure, Pneumonia, Acute Coronary Syndromes, Unstable Angina, Myocardial Infarction, Cardiac Arrhythmia, Thromboembolic Disease
Interventions: Normal Saline, Sodium Bicarbonate; Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Sickle Cell Disease, Pain
Interventions: Immune Globulin Intravenous (IVIG), Normal saline; Drug · Other
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 6 Years to 13 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Video-Assisted Thoracic Surgery, Video-Assisted Thoracoscopic Surgery
Interventions: Normal Saline, Ropivacaine, Epinephrine, Dexamethasone; Drug
Lead sponsor: University at Buffalo; Other
Eligibility: 18 Years to 85 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Water Stress, Body Water Dehydration
Interventions: Hypertonic Saline, Normal Saline; Other
Lead sponsor: University of North Carolina, Greensboro; Other
Eligibility: 18 Years to 35 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Greensboro, North Carolina

Conditions: Coronavirus Disease 2019 (COVID-19), Acute Lung Injury, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Interventions: Dociparstat sodium, Placebo; Drug
Lead sponsor: Jazz Pharmaceuticals; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 12
States / cities: Birmingham, Alabama • Loxahatchee Groves, Florida • Augusta, Georgia + 8 more

Conditions: Atopy
Interventions: AK001, Placebo; Drug
Lead sponsor: Allakos Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Cypress, California

Conditions: Osteoporotic Fractures
Interventions: Teriparatide Prefilled Syringe, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 65 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Lung Cancer
Interventions: Ketamine, 0.9% saline; Drug
Lead sponsor: Duke University; Other
Eligibility: Not listed
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Congenital Hyperinsulinism
Interventions: Exendin-(9-39), placebo; Drug
Lead sponsor: Diva De Leon; Other
Eligibility: 6 Months to 18 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pain, Postoperative
Interventions: Bupivacaine, 0.9% Sodium Chloride; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: Healthy
Interventions: Liposomal Bupivacaine 13.3, Bupivacaine, Placebo; Drug · Other
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Dyspepsia, Healthy
Interventions: Human Secretin, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Rochester, Minnesota

Search by objective public record fields.

Esophageal Echo Assessment of LV Function During Acute Normovolemic Hemodilution Using Crystalloid or Hypertonic Saline

Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery

International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project

Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion

Treatment of Corneal Abrasions With Topical Tetracaine

Study of Antithymocyte Globulin for Treatment of New-onset T1DM

A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI

Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department

Endometrial Rejuvenation Study

TXA in Spinal Fusion

Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty

A Low ChloridE hyperTonic Solution for Brain Edema

Clearance Of Mucus In Stents (COMIS)

Intravenous Gammaglobulin for Sickle Cell Pain Crises

Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries

Influence of Osmotic Stimulation of Vasopressin on Autonomic Function

Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK001

PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial

Ketamine In Thoracic Surgery (KITS) Trial

Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity

Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.

Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers

Effect of Secretin in Functional Dyspepsia and Healthy Subjects