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ClinicalTrials.gov public records Last synced Nov 7, 2026, 3:07 PM EST

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Showing 1–24 of 104 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Ketamine Hydrochloride Clear all

Conditions: Major Depressive Disorder
Interventions: (2R,6R)-Hydroxynorketamine hydrochloride, Placebo; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Anesthesia, Tooth Extraction
Interventions: Midazolam Hydrochloride, Fentanyl, Ketamine, Propofol injection, Nitrous oxide; Drug
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 16 Years and older
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Bipolar Depression, Suicidal Ideas, Suicidal Ideation, Suicide, Attempted
Interventions: NRX-101 Oral Capsule, Lurasidone Oral Capsule, Ketamine Intravenous Infusion, Saline Solution Intravenous Infusion; Drug
Lead sponsor: NeuroRx, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 4
States / cities: Birmingham, Alabama • Fort Lauderdale, Florida • Charlotte, North Carolina + 1 more

Conditions: Post-Traumatic Stress Disorders, Major Depressive Disorder
Interventions: Ketamine, Normal Saline; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 75 Years
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Suicidal Ideation, Depressive Episode
Interventions: Ketamine Hydrochloride, Music; Drug · Other
Lead sponsor: The University of Texas Health Science Center at Tyler; Other
Eligibility: 18 Years to 64 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Tyler, Texas

Conditions: Anesthesia, Pain
Interventions: Ketorolac Tromethamine, Hydromorphone, Ketamine, Oxycodone, Morphine, Fentanyl (IV); Drug
Lead sponsor: Chi Dang Hornik; Other
Eligibility: 6 Months to 17 Years
Enrollment: 551 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 11
States / cities: Stanford, California • Aurora, Colorado • Wilmington, Delaware + 7 more

Conditions: Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
Interventions: Ketamine hydrochloride, Morphine sulphate; Drug
Lead sponsor: Columbia University; Other
Eligibility: 6 Years to 17 Years
Enrollment: 1,010 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 8
States / cities: Los Angeles, California • Sacramento, California • Wilmington, Delaware + 5 more

Conditions: Bipolar Disorder
Interventions: Standard of Care, Ketamine, D-cycloserine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Sepsis
Interventions: Ketamine, Normal Saline placebo; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 21 Years to 100 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Stress Disorders, Post-Traumatic, PTSD, Depression, Anxiety Disorder
Interventions: Midazolam, Ketamine; Drug
Lead sponsor: Dennis Charney; Other
Eligibility: 21 Years to 55 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Suicidal Ideation, Suicide
Interventions: Ketamine Hydrochloride; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obsessive-Compulsive Disorder
Interventions: Ketamine, Naltrexone Pill, Placebo pill; Drug · Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Stanford, California

Conditions: Healthy
Interventions: Ketamine, Saline (placebo); Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 45 Years
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Failed Moderate Sedation During Procedure, Ketamine Adverse Reaction
Interventions: Ketamine Hcl 100Mg/Ml Inj; Drug
Lead sponsor: University of Arizona; Other
Eligibility: 2 Years to 7 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Sedation
Interventions: Dexmedetomidine load, Ketamine load, Midazolam load, Fentanyl load, Dexmedetomidine maintenance, Ketamine maintenance, Midazolam demand, Fentanyl demand, Benadryl demand; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder, Depressive Disorder
Interventions: Ketamine Hydrochloride; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Suicide
Interventions: Ketamine Hydrochloride, Crisis Response Plan; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 70 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Healthy Volunteers, Depression
Interventions: Magnetic Resonance Imaging scanner, 3T, NeurOptics PLRTM-3000 Pupillometer, Experimental Anxiety Devices, Magnetic Resonance Imaging scanner, 7T, Ketamine Hydrochloride; Device · Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 325 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2030
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Suicide, Attempted
Interventions: Ketamine Hydrochloride, Saline, CAMS Therapy; Drug · Behavioral
Lead sponsor: Tatiana Falcone, MD; Other
Eligibility: 14 Years to 30 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Depressive Disorder, Major, Suicidal
Interventions: SLS-002, Placebo, Standard of care, Intranasal device; Drug · Other · Device
Lead sponsor: Seelos Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 21
States / cities: Orange, California • Panorama City, California • San Diego, California + 18 more

Conditions: Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission, Major Depressive Disorder
Interventions: Ketamine-assisted psychotherapy; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 64 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Healthy Controls
Interventions: Ketamine, Normal saline; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 55 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 3
States / cities: Sacramento, California • New Haven, Connecticut • New York, New York

Conditions: Chronic Pain
Interventions: Ketamine; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 8 Years to 22 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Hemorrhage, Healthy
Interventions: Ketamine Hydrochloride, Placebo; Drug · Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 45 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Dallas, Texas

Search by objective public record fields.

Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

Sequential Therapy for the Treatment of Severe Bipolar Depression.

Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

A Single Ketamine Infusion Combined With Music for Suicidal Ideation

Anesthetics and Analgesics in Children

Morphine or Ketamine for Analgesia

NMDA Antagonists in Bipolar Depression

Immunomodulatory Properties of Ketamine in Sepsis

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

The Impact of Ketamine on the Reward Circuitry of Suicidal Patients

Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)

The Effects of Low Dose Ketamine on Cardiovascular Function

Intranasal Ketamine for Pediatric Procedural Sedation: a Feasibility Study

Alternative Sedation During Bronchoscopy

Ketamine for OUD and Comorbid Depression (OUDCD)

Ketamine & Crisis Response Plan for Suicidal Ideation in the ED

Neurobiology of Suicide

Ketamine Treatment of Youth Suicide Attempters

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

KAP for Depression in Abstinent Opioid Users

Biomarker Assessment of Glutamatergic Target Engagement

Oral Ketamine for Control of Chronic Pain in Children

Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine