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ClinicalTrials.gov public records Last synced Sep 30, 2026, 6:22 AM EDT

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Showing 25–48 of 67 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Ketamine low-dose Clear all
Not listed Phase 1 Interventional Accepts healthy volunteers

Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

NCT01736020
View directory record Official record
Conditions
Healthy
Interventions
Dexmedetomidine, Propofol, Ketamine, Nitrous Oxide, Placebo
Drug
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 35 Years
Enrollment
293 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Sep 30, 2026, 6:22 AM EDT
Active, not recruiting Phase 2 Interventional

Ketamine for Multiple Sclerosis Fatigue

NCT05378100
View directory record Official record
Conditions
Multiple Sclerosis Fatigue
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 30, 2026, 6:22 AM EDT
Terminated Phase 4 Interventional Results available

Ketamine Pilot Study

NCT05379179
View directory record Official record
Conditions
Rattlesnake Envenomation
Interventions
Ketamine, Fentanyl
Drug
Lead sponsor
Meghan Spyres
Other
Eligibility
18 Years to 100 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 4 Interventional Results available

Low Dose Ketamine for Blunt Thoracic Trauma

NCT06236113
View directory record Official record
Conditions
Blunt Injury of Thorax, Multiple Rib Fractures, Involving Three Ribs
Interventions
Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution
Drug
Lead sponsor
North Memorial Health Care
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Robbinsdale, Minnesota
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Perioperative Ketamine for Pain With Gastric Bypass

NCT03448068
View directory record Official record
Conditions
Laparoscopic Gastric Bypass Surgery, Ketamine
Interventions
Ketamine, Standard therapy
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 69 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Sep 30, 2026, 6:22 AM EDT
Withdrawn Phase 2 Interventional

Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures

NCT04061330
View directory record Official record
Conditions
Pain, Acute
Interventions
Ketamine, Morphine
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Early Phase 1 Interventional

Prevention of Post Mastectomy With Intraoperative Ketamine

NCT03090776
View directory record Official record
Conditions
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome
Interventions
Ketamine, Placebo saline
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 2 Interventional Results available

Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients

NCT02935595
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Ketamine
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 30, 2026, 6:22 AM EDT
Terminated Phase 4 Interventional Results available

Effect of Ketamine on Postoperative Clinical Outcomes

NCT01365195
View directory record Official record
Conditions
Colorectal Surgery
Interventions
Placebo, Ketamine high-dose, Ketamine low-dose
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 4 Interventional Results available

Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects

NCT05518877
View directory record Official record
Conditions
Pain, Acute, Dissociation
Interventions
Ketamine
Drug
Lead sponsor
Summa Health System
Other
Eligibility
18 Years to 110 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 30, 2026, 6:22 AM EDT
Enrolling by invitation Phase 2 Interventional Accepts healthy volunteers

Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study

NCT07705022
View directory record Official record
Conditions
Healthy, Covert Consciousness
Interventions
Dexmedetomidine (+propofol as indicated), Ketamine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 30, 2026, 6:22 AM EDT
Terminated Phase 4 Interventional Results available

RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain

NCT03305055
View directory record Official record
Conditions
Acute Pain, Wound Care, Posttraumatic Stress Disorder
Interventions
ketamine, Fentanyl
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 30, 2026, 6:22 AM EDT
Terminated Phase 1 Interventional

Pharmacokinetics of Low Dose Ketamine Infusion

NCT00618397
View directory record Official record
Conditions
Sedation, Opioid Tolerance
Interventions
Ketamine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
3 Years to 18 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 2 Interventional

Low Dose Ketamine VR Analgesia During Burn Care Procedure

NCT01889537
View directory record Official record
Conditions
Burn
Interventions
Virtual Reality
Behavioral
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years to 85 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 1, 2017 · Synced Sep 30, 2026, 6:22 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Low Dose Ketamine Infusion for the Treatment of Resistant Depression

NCT04283058
View directory record Official record
Conditions
Depression
Interventions
Ketamine
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 89 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 1, 2020 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 1 Interventional

Ketamine for Low Mood States in the ER

NCT01209845
View directory record Official record
Conditions
Depression, Suicide Ideation
Interventions
ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Sep 30, 2026, 6:22 AM EDT
Terminated Phase 1 Interventional Results available

The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study

NCT05229653
View directory record Official record
Conditions
Endometriosis, Post Operative Pain
Interventions
Ketamine, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 28, 2025 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department

NCT01835262
View directory record Official record
Conditions
Pain
Interventions
Morphine, Ketamine
Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 3 Interventional Results available

Ketamine Infusion for Comorbid PTSD and Chronic Pain

NCT04322968
View directory record Official record
Conditions
PTSD, Chronic Pain
Interventions
A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms.
Drug
Lead sponsor
VA Ann Arbor Healthcare System
Federal
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Low-Dose Ketamine in Children With ADNP Syndrome

NCT04388774
View directory record Official record
Conditions
ADNP Syndrome
Interventions
Ketamine
Drug
Lead sponsor
Alexander Kolevzon
Other
Eligibility
5 Years to 12 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2023 · Synced Sep 30, 2026, 6:22 AM EDT
Withdrawn Phase 4 Interventional

Exploring the Safety and Efficacy of Low-dose Ketamine Infusions for Pain Control in Acute Burn Injury

NCT03095222
View directory record Official record
Conditions
Pain
Interventions
Ketamine, Opioids
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Assessment of Effect of Rapastinel on Driving Performance

NCT03814733
View directory record Official record
Conditions
Driving Performance
Interventions
Rapastinel, Alprazolam, Ketamine, Rapastinel Matched Placebo, Alprazolam Matched Placebo, Ketamine Matched Placebo
Drug
Lead sponsor
Naurex, Inc, an affiliate of Allergan plc
Industry
Eligibility
21 Years to 65 Years
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Clemente, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Sep 30, 2026, 6:22 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy

NCT02452060
View directory record Official record
Conditions
Pain, Postoperative Depression
Interventions
Ketamine, Placebo Comparator
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Sep 30, 2026, 6:22 AM EDT
Terminated Phase 2 Interventional Results available

Low-Dose Ketamine Infusion for Children With Sickle Cell Disease-Related Pain

NCT00595530
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
ketamine
Drug
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
7 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Farmington, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Sep 30, 2026, 6:22 AM EDT