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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Ketone Clear all
Completed Phase 4 Interventional Results available

Dichotic Listening as a Predictor of Medication Response in Depression

NCT00404755
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia
Interventions
escitalopram, bupropion, imipramine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2018 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance

NCT05651243
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Ketone Ester Supplement, Placebo
Dietary Supplement · Other
Lead sponsor
University of Southern Mississippi
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hattiesburg, Mississippi
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Sep 20, 2026, 10:01 AM EDT
Active, not recruiting Phase 2 Interventional

Combination of Novel Therapies for CKD Comorbid Depression

NCT04422652
View directory record Official record
Conditions
Chronic Kidney Diseases, Major Depressive Disorder, End Stage Kidney Disease (ESRD)
Interventions
Bupropion, Behavioral activation therapy, Placebo, Clinical Management
Drug · Behavioral · Other
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
4
States / cities
Stony Brook, New York • Dallas, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.

NCT06449287
View directory record Official record
Conditions
Ketogenic Diet, Weight Loss
Interventions
Diet, Blood Draw, Ketone/Glucose Monitoring, Body Composition, Urine Analysis, Neuropsychological Measures - ANAM
Other · Biological · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Not applicable Interventional Results available

Adapting Diabetes Treatment Expert Systems to Patient in Type 1 Diabetes

NCT04443153
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Personalized Feedback, Decision Support System, Sensor Augmented Mode
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 20, 2026, 10:01 AM EDT
Recruiting Not applicable Interventional

BHB & CAR-T for Lymphomas

NCT06610344
View directory record Official record
Conditions
Large B-cell Lymphoma
Interventions
R-1,3-Butanediol
Dietary Supplement
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 4 Interventional Results available

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

NCT03726268
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative
Interventions
Methadone, Fentanyl, Hydromorphone, Morphine, Sufentanil
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
907 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Sep 20, 2026, 10:01 AM EDT
Terminated Phase 4 Interventional

Clozapine Versus Haloperidol for Treating the First Episode of Schizophrenia

NCT00169091
View directory record Official record
Conditions
Schizophrenia
Interventions
Clozapine, Haloperidol
Drug
Lead sponsor
Harvard Medical School (HMS and HSDM)
Other
Eligibility
18 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2003
U.S. locations
1
States / cities
Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study Comparing ABT-335 Coadministered With Atorvastatin and Ezetimibe to Atorvastatin Coadministered With Ezetimibe in Subjects With Multiple Abnormal Lipid (Fat) Levels in the Blood

NCT00639158
View directory record Official record
Conditions
Dyslipidemias, Coronary Heart Disease, Combined (Atherogenic) Dyslipidemia, Mixed Dyslipidemia
Interventions
ABT-335, placebo, atorvastatin, ezetimibe
Drug
Lead sponsor
Abbott
Industry
Eligibility
18 Years and older
Enrollment
543 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
118
States / cities
Birmingham, Alabama • Columbiana, Alabama • Hueytown, Alabama + 107 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2011 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Methadone Maintenance for Prisoners

NCT00378079
View directory record Official record
Conditions
Heroin Addiction
Interventions
Counseling Only, Counseling + Transfer, Counseling + Methadone
Other · Drug
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 2, 2014 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients

NCT00879996
View directory record Official record
Conditions
Opiate Addiction
Interventions
Methadone, Buprenorphine/naloxone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2012 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 2 Interventional Results available

Neural Substrates in Nicotine Withdrawal

NCT01001520
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Tolcapone, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 1, 2014 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrated Smoking Cessation Treatment for Low Income Community Corrections

NCT01257490
View directory record Official record
Conditions
Smoking Cessation
Interventions
counseling vs. advice
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 80 Years
Enrollment
689 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Not applicable Interventional Results available

Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery

NCT01592708
View directory record Official record
Conditions
Post-operative Nausea, Post-operative Vomiting, Nausea Persistent
Interventions
Antiemetic anesthesia protocol
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 4 Interventional

Reducing Pain With Methadone and Ketamine in Liver Transplant

NCT06868589
View directory record Official record
Conditions
Liver Transplantation
Interventions
Methadone, ketamine, Hydromorphone, fentanyl
Drug
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 20, 2026, 10:01 AM EDT
Terminated Phase 4 Interventional Results available

The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy

NCT02252432
View directory record Official record
Conditions
Laminectomy
Interventions
Ketamine, Methadone, Ketamine + methadone
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 2 Interventional Results available

Tolcapone Treatment of Pathological Gambling

NCT00927563
View directory record Official record
Conditions
Pathological Gambling
Interventions
Tolcapone
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Sep 20, 2026, 10:01 AM EDT
Terminated Phase 2 Interventional Results available

Combination Pain Therapy in HIV Neuropathy

NCT00863057
View directory record Official record
Conditions
HIV Infections, Peripheral Neuropathy
Interventions
Duloxetine, Duloxetine placebo, Methadone, Methadone placebo
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
8
States / cities
San Diego, California • Torrance, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 1 Interventional Results available

Ketone Pharmacokinetic Study in HFrEF

NCT05757193
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
DeltaG (250 mg/kg), DeltaG (500 mg/kg)
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Sep 20, 2026, 10:01 AM EDT
Completed No phase listed Observational Results available

Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc

NCT04980378
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
18
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 20, 2026, 10:01 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis

NCT06609343
View directory record Official record
Conditions
End Stage Renal Disease, Fatigue
Interventions
Bupropion Hydrochloride 150 MG
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
25 Years to 74 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

NCT01574703
View directory record Official record
Conditions
Smoking Cessation
Interventions
placebo, varenicline tartrate, bupropion hydrochloride, Nicotine Replacement Therapy Patch
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
4,595 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
65
States / cities
Mobile, Alabama • Encino, California • Escondido, California + 54 more
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Sep 20, 2026, 10:01 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones

NCT05778695
View directory record Official record
Conditions
Parkinson Disease, Lewy Body Dementia, Parkinson Disease Dementia
Interventions
Ketone Ester (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
45 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Sep 20, 2026, 10:01 AM EDT
Completed Phase 2 Interventional Results available

Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study

NCT04499950
View directory record Official record
Conditions
Breast Cancer, Overweight or Obesity
Interventions
Contrave, Behavioral Weight Loss
Drug · Behavioral
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older · Female only
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Sep 20, 2026, 10:01 AM EDT