- Conditions
- Alzheimer Disease
- Interventions
- Challenge A - low calorie Ensure®, Challenge B - Ensure® plus ketone esters (KE), PET Scan, Cognitive Testing - FCSRT, Story Recall, BVRT, CogState One Card Learning
- Dietary Supplement · Procedure · Behavioral
- Lead sponsor
- Wake Forest University Health Sciences
- Other
- Eligibility
- 50 Years to 85 Years
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- Winston-Salem, North Carolina
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Showing 1–12
of 12
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Type 2 Diabetes, Ketone Body Metabolism, Ketones, Metabolism
- Interventions
- Ketone Ester Acute, Placebo Acute
- Dietary Supplement
- Lead sponsor
- Ohio State University
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2027
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Heart Failure With Reduced Ejection Fraction
- Interventions
- ketone ester, placebo
- Dietary Supplement
- Lead sponsor
- Duke University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 25 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2026
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Alcohol Drinking
- Interventions
- Ketone Supplement, Alcohol Beverage
- Dietary Supplement · Other
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 21 Years to 50 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2022 – 2027
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Flavor Perception in Normal, Healthy Adults
- Interventions
- Flavor additive
- Other
- Lead sponsor
- Monell Chemical Senses Center
- Other
- Eligibility
- 21 Years to 45 Years
- Enrollment
- 19 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020 – 2021
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Brain Health
- Interventions
- Ketone Ester Drink, Placebo
- Dietary Supplement
- Lead sponsor
- Christopher Crabtree
- Other
- Eligibility
- 45 Years to 65 Years
- Enrollment
- 24 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Parkinson Disease, Ketosis
- Interventions
- Ketone Ester Elite endurance Nutrition Drink, Stool Sample
- Dietary Supplement · Other
- Lead sponsor
- University of Florida
- Other
- Eligibility
- 40 Years to 75 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2020
- U.S. locations
- 1
- States / cities
- Gainesville, Florida
- Conditions
- Healthy
- Interventions
- FDG, Ketone Drink, Ketogenetic Diet
- Drug · Dietary Supplement · Other
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020 – 2023
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Drinking
- Interventions
- Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", FDG
- Dietary Supplement · Drug
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2027
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Metabolic Syndrome, Normal Cognition
- Interventions
- Ketone Ester drink, Placebo: isocaloric dextrose drink
- Dietary Supplement
- Lead sponsor
- National Institute on Aging (NIA)
- NIH
- Eligibility
- 55 Years and older
- Enrollment
- 99 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2025
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Alcohol Drinking, Alcohol Use Disorder
- Interventions
- Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Isocaloric dextrose placebo, Alcohol drinks
- Dietary Supplement · Drug · Other
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2027
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Interventions
- Ketone ester, placebo drink
- Dietary Supplement
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 26 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2023
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania