Independent directory Public ClinicalTrials.gov records United States
Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 15, 2026, 12:44 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 217–240 of 865 matching trials from the live ClinicalTrials.gov search.
Conditions
Knee Arthritis, Knee Osteoarthritis, Knee Pain Chronic, Knee Discomfort, Rheumatoid Arthritis, Knee Pain Swelling
Interventions
Gold Factor (Gold Nanoparticles, AuNPs), Placebo
Dietary Supplement
Lead sponsor
4Life Research, LLC
Industry
Eligibility
18 Years to 87 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
St Louis, Missouri
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adipose-derived SVF for the Treatment of Knee OA

NCT02726945
Conditions
Osteoarthritis (OA)
Interventions
GID SVF-2, Placebo
Device · Other
Lead sponsor
GID BIO, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
3
States / cities
Camden, New Jersey • Egg Harbor, New Jersey • San Antonio, Texas
Conditions
Knee Osteoarthristis
Interventions
Dephy Exoboot
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
21 Years to 100 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Cambridge, Massachusetts
Conditions
Osteoarthritis, Knee
Interventions
Zilretta, Synvisc-One 48 MG in 6 ML Prefilled Syringe, Monovisc 88 MG Per 4 ML Prefilled Syringe
Drug
Lead sponsor
Ohio State University
Other
Eligibility
25 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Columbus, Ohio • Lewis Center, Ohio
Conditions
Knee Osteoarthritis
Interventions
Shared Decision Making Tool
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
45 Years to 64 Years · Female only
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Conditions
Osteoarthritis
Interventions
Hylan G-F 20
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
41 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
West Orange, New Jersey
Conditions
Osteoarthritis of Knee
Interventions
Triamcinolone Acetonide Low Dose, Triamcinolone Acetonide Standard Dose
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
55 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Conditions
Knee Arthritis
Interventions
Cannabidiol (CBD), Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Active, not recruiting Phase 1Phase 2 Interventional

The Role of Vitamin K on Knee Osteoarthritis Outcomes

NCT06385275
Conditions
Osteo Arthritis Knee
Interventions
Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
50 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Terminated No phase listed Observational

Clinical Outcomes of Knee Replacement

NCT01705366
Conditions
Knee Arthroplasty
Interventions
Non-MAKO® Robot Assisted Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, MAKO® Robot Assisted Medial and PF Knee Arthroplasty, RESTORIS Multicompartmental Knee System, Depuy Knee Replacement System, Stryker® Knee Replacement System
Procedure · Device
Lead sponsor
Northwest Surgical Specialists, Vancouver
Other
Eligibility
21 Years and older
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Vancouver, Washington
Completed Not applicable Interventional Results available

Tai Chi Mind-Body Therapy for Knee Osteoarthritis

NCT00362453
Conditions
Knee Osteoarthritis
Interventions
Tai Chi versus Attention Control
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
55 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Osteoarthritis, Knee
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Completed Not applicable Interventional

Yoga for Rheumatoid Arthritis

NCT00349869
Conditions
Rheumatoid Arthritis, Osteoarthritis
Interventions
yoga
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Active, not recruiting Not applicable Interventional

Persona Ti-Nidium Post-Market Clinical Follow-up

NCT04817969
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis
Interventions
Zimmer Biomet Persona Ti-Nidium Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2034
U.S. locations
7
States / cities
Parker, Colorado • Hyattsville, Maryland • Jackson, Mississippi + 4 more
Conditions
Osteoarthritis of the Knee or Hip
Interventions
Fasinumab, Placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
5,331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
50
States / cities
Birmingham, Alabama • Chandler, Arizona • Glendale, Arizona + 44 more
Conditions
Osteo Arthritis Knee
Interventions
Ropivacaine
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Roanoke, Virginia
Conditions
Osteoporosis, Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
Edward Fox
Other
Eligibility
40 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Completed Not applicable Interventional Results available

Geniculate Artery Embolization for Knee Osteoarthritis

NCT04951479
Conditions
Knee Osteoarthritis
Interventions
Gel-Bead embolization
Device
Lead sponsor
Anish Ghodadra
Other
Eligibility
18 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Results available

Brain Morphometry in OA Patients Treated With Duloxetine

NCT02903238
Conditions
Pain, Osteoarthritis
Interventions
Duloxetine, Placebo Oral Tablet
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Osteoarthritis
Interventions
Massage Therapy
Procedure
Lead sponsor
Duke University
Other
Eligibility
35 Years and older
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
3
States / cities
Derby, Connecticut • Morristown, New Jersey • Durham, North Carolina
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Preoperative Methadone, Preoperative Oxycodone
Drug
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Louisville, Kentucky
Conditions
Degenerative Arthritis
Interventions
Placebo, Ibuprofen modified release tablet 800 mg
Drug
Lead sponsor
Overseas Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
7
States / cities
Cerritos, California • Garden Grove, California • Santa Ana, California + 4 more
Conditions
Osteoarthritis of the Knee
Interventions
iTotal G2 CR Knee Replacement System
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
9
States / cities
Atlantis, Florida • Bangor, Maine • Battle Creek, Michigan + 6 more
Conditions
Osteoarthritis, Knee
Interventions
Bone Marrow Derived MSCs, Corticosteroid, Bone Marrow Aspirate
Biological · Drug · Device
Lead sponsor
Next Generation Regenerative Medicine LLC
Network
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Chesterfield, Missouri • Steubenville, Ohio • Salt Lake City, Utah