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ClinicalTrials.gov public records Last synced Oct 16, 2026, 1:05 PM EDT

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Showing 601–624 of 865 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Knee Osteoarthritis Clear all
Completed Phase 2 Interventional Results available

A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee

NCT02068599
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
TV-45070, Placebo
Drug
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
389 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
42
States / cities
Anaheim, California • Cerritos, California • El Cajon, California + 35 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 2 Interventional

Tidal Lavage in Knee Osteoarthritis

NCT00000424
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Tidal lavage vs. sham lavage of the knee
Procedure
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
40 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2001
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2007 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High-speed Power Training in Older Adults With Knee Osteoarthritis (OA)

NCT01328340
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
High-speed power training, Slow-speed strength training
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
55 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 4, 2016 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 4 Interventional Results available

The Effect of Intra-articular Bilateral Knee Injections of Zilretta on Performance Measures in Adults With Knee OA

NCT03895840
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Zilretta
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
30 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 16, 2026, 1:05 PM EDT
Not listed Not applicable Interventional

Use of Autologous Adipose-Derived Stromal Vascular Fraction To Treat Osteoarthritis of Hip, Knee, Ankle, and Thumb Joints

NCT03166410
View directory record Official record
Conditions
Osteoarthritis
Interventions
Cell injection
Procedure
Lead sponsor
Texas Plastic Surgery
Industry
Eligibility
25 Years to 85 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 13, 2020 · Synced Oct 16, 2026, 1:05 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)

NCT00704847
View directory record Official record
Conditions
Osteoarthritis
Interventions
Oral Salmon Calcitonin, Oral Salmon Calcitonin (Placebo)
Drug
Lead sponsor
Nordic Bioscience A/S
Industry
Eligibility
51 Years to 80 Years
Enrollment
1,030 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
6
States / cities
Tuscaloosa, Alabama • Sacramento, California • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 16, 2026, 1:05 PM EDT
Not yet recruiting Phase 2 Interventional

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

NCT07189585
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
inulin, Maltodextrin (Placebo)
Drug
Lead sponsor
Yale University
Other
Eligibility
40 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional

The Arthritis, Diet, and Activity Promotion Trial

NCT00979043
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Dietary Weight-loss, Exercise
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
318 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 1 Interventional

Flavocoxid, A Plant-Derived Therapy, for the Treatment of Knee Osteoarthritis

NCT00294125
View directory record Official record
Conditions
Osteoarthritis
Interventions
Flavocoxid, Placebo
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years to 75 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 22, 2013 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 1 Interventional

Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Faction (SVF) for Treatment of Osteoarthritis of the Knee

NCT03940950
View directory record Official record
Conditions
Osteo Arthritis Knee, Degenerative Joint Disease of Knee
Interventions
Autologous Adipose-Derived SVF (Stromal Vascular Fraction), Placebo
Biological · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 16, 2026, 1:05 PM EDT
Active, not recruiting Phase 1 Interventional

Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis

NCT05835895
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Osteoarthritis
Interventions
GNSC-001, transient immune-modulation, Placebo
Genetic · Drug
Lead sponsor
Genascence Corporation
Industry
Eligibility
40 Years to 75 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
9
States / cities
Mobile, Alabama • La Mesa, California • San Diego, California + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Results available

Safety and Effectiveness of Monovisc® Injection for Osteoarthritis of the Knee

NCT00653432
View directory record Official record
Conditions
Osteoarthritis
Interventions
Monovisc®, Saline
Device · Other
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
35 Years to 75 Years
Enrollment
369 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
30
States / cities
Hoover, Alabama • Mesa, Arizona • Phoenix, Arizona + 27 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2023 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Results available

Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP)

NCT03780400
View directory record Official record
Conditions
Osteoarthritis
Interventions
Osteoarthritis Physical Activity Care Pathway
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2020 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating the Impact of a Shared Decision-Making Tool

NCT05411939
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Shared Decision-Making Tool, Video, Standard of Care
Other
Lead sponsor
Yale University
Other
Eligibility
45 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
3
States / cities
Guilford, Connecticut • Milford, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 16, 2026, 1:05 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Knee Brace When Combined With Viscosupplementation in the Treatment of Knee Osteoarthritis

NCT01478386
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Orthovisc, DonJoy HA lite knee brace, Orthovisc injections and DonJoy HA lite knee brace
Other · Device
Lead sponsor
OAD Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Warrenville, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 23, 2013 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 3 Interventional Results available

AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee

NCT03182686
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
4 mL injection of Ampion, 4 mL Injection of Placebo
Biological · Drug
Lead sponsor
Ampio Pharmaceuticals. Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
13
States / cities
Birmingham, Alabama • Encinitas, California • Fullerton, California + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2022 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain

NCT01351805
View directory record Official record
Conditions
Autoimmune Diseases, Systemic Inflammatory Process, Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis
Interventions
Fish Oil, Vitamin D, placebo pill
Drug · Dietary Supplement · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
50 Years and older
Enrollment
25,871 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 16, 2026, 1:05 PM EDT
Completed No phase listed Observational

A Single-Center, Epidemiological Study of the Survivorship of the DePuy Sigma HP Unicompartmental Knee Prosthesis

NCT01656694
View directory record Official record
Conditions
Osteoarthritis, Unicompartmental Knee Arthroscopy
Interventions
DePuy Sigma HP Partial Knee
Device
Lead sponsor
Mississippi Sports Medicine and Orthopaedic Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Initial Graft Tension and ACL Surgery

NCT00434837
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Initial graft tension during ACL reconstruction surgery
Procedure
Lead sponsor
Rhode Island Hospital
Other
Eligibility
15 Years to 50 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2024
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 2 Interventional

Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee

NCT00371670
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
balicatib (AAE581)
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
40 Years to 80 Years
Enrollment
223 participants
Timeline
Started 2004
U.S. locations
1
States / cities
Anniston, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Oct 16, 2026, 1:05 PM EDT
Recruiting Phase 2 Interventional

Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

NCT03491761
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
PRP Treatment, HA Treatment
Biological
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Long-Duration Ultrasound for Knee Osteoarthritis

NCT03800927
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Long duration ultrasound
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Stamford, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Oct 16, 2026, 1:05 PM EDT
Terminated Not applicable Interventional Results available

Long-Term Effectiveness of Walking Training in Patients With Knee Osteoarthritis

NCT02767570
View directory record Official record
Conditions
Osteoarthritis
Interventions
Gait Training; Altered Foot Progression Angle, Gait Training; Consistent Foot Progression Angle
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2022 · Synced Oct 16, 2026, 1:05 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee

NCT00504127
View directory record Official record
Conditions
Osteoarthritis
Interventions
Naproxcinod 375 mg bid, Naproxcinod 750 mg bid, Naproxen 500 mg bid, placebo
Drug
Lead sponsor
NicOx
Industry
Eligibility
40 Years and older
Enrollment
1,020 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
73
States / cities
Chandler, Arizona • Tempe, Arizona • Tucson, Arizona + 70 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2011 · Synced Oct 16, 2026, 1:05 PM EDT