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Showing 25–40 of 16 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction

NCT03679780
View directory record Official record
Conditions
Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
Interventions
BQ-788, BQ-123, L-Arginine, NG Nitro L Arginine Methyl Ester, Sodium Nitroprusside, Lactated Ringer's
Drug
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 4, 2026, 2:55 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations

NCT04612738
View directory record Official record
Conditions
Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness, Communication
Interventions
Hello (serious game), The Conversation Project (CP) Starter Kit, Table Topics (general conversation game)
Behavioral · Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
79
States / cities
Athens, Alabama • Kingman, Arizona • Show Low, Arizona + 70 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1

NCT04481035
View directory record Official record
Conditions
Neurofibromatosis 1
Interventions
N-acetylcysteine (NAC), Placebo
Drug · Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years to 16 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Local Antioxidant Therapy Vasoconstriction Effects in Different Races

NCT03684213
View directory record Official record
Conditions
Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
Interventions
Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME, Norepinephrine + L-NAME + Ascorbic Acid
Drug
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 35 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 4, 2026, 2:55 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation

NCT06499844
View directory record Official record
Conditions
Endothelial Function
Interventions
Acetylcholine
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 30 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Sep 4, 2026, 2:55 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Prenatal Aspirin and Postpartum Vascular Function

NCT05653973
View directory record Official record
Conditions
Preeclampsia, Microvascular Function
Interventions
Acetylcholine, Endothelin-1
Drug
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study

NCT04749745
View directory record Official record
Conditions
Cortical Excitability, Psychiatric Disorder
Interventions
L-theanine, Placebo
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Sep 4, 2026, 2:55 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia

NCT07715669
View directory record Official record
Conditions
Preeclampsia, Endothelial Function
Interventions
Paroxetine Hydrochloride, Ascorbic acid (Vitamin C)
Drug
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 4, 2026, 2:55 PM EDT
Withdrawn Early Phase 1 Interventional

Novel Supplement-based Therapy for the Treatment of Small Intestinal Bacterial Overgrowth

NCT03420976
View directory record Official record
Conditions
Small Intestinal Bacterial Overgrowth
Interventions
Novel Supplement Based Therapy
Dietary Supplement
Lead sponsor
Atrium Innovations
Industry
Eligibility
19 Years to 84 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Oxford, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Sep 4, 2026, 2:55 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM

NCT06547619
View directory record Official record
Conditions
Gestational Diabetes, Endothelial Dysfunction, Physical Inactivity
Interventions
Insulin aspart
Drug
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Phase 2 Interventional Results available

A Placebo-Controlled Trial of St. John's Wort for Irritable Bowel Syndrome

NCT00587860
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
St. John's wort, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 8, 2010 · Synced Sep 4, 2026, 2:55 PM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

NCT05946798
View directory record Official record
Conditions
Gestational Diabetes, Oxidative Stress, Vascular Endothelial Function
Interventions
Acetylcholine, Insulin aspart
Drug
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 4, 2026, 2:55 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

The Impact of Gestational Diabetes Mellitus on Cerebral Blood Flow and Cerebrovascular Function After Pregnancy

NCT06911372
View directory record Official record
Conditions
Gestational Diabetes Mellitus (GDM), Postpartum Women, Uncomplicated Pregnancy
Interventions
Intradermal Microdialysis, Brain Blood Flow Tests, Local Heating
Drug · Other
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Tyrosine in Restless Legs Syndrome

NCT01494766
View directory record Official record
Conditions
Restless Legs Syndrome (RLS)
Interventions
L-Tyrosine
Dietary Supplement
Lead sponsor
Seton Healthcare Family
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2017 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling

NCT00603720
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
L-NAME, L-Arginine, Phenylephrine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Sep 4, 2026, 2:55 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Prevention of Low Blood Pressure in Persons With Tetraplegia

NCT00237770
View directory record Official record
Conditions
Hypotension, Spinal Cord Injury
Interventions
N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
Drug · Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2010
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 18, 2014 · Synced Sep 4, 2026, 2:55 PM EDT