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Showing 1–24 of 105 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: L-leucine Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Metabolomic Impacts of Branched-chain Amino Acid Supplementation During Endurance Exercise

NCT04969536
View directory record Official record
Conditions
Healthy
Interventions
Branched Chain Amino Acids, Placebo
Dietary Supplement · Other
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 6, 2026, 5:19 AM EDT
Active, not recruiting Phase 3 Interventional

A Pivotal Study of N-Acetyl-L-Leucine on Ataxia-Telangiectasia (A-T)

NCT06673056
View directory record Official record
Conditions
Ataxia-Telangiectasia, Ataxia-Telangiectasia (A-T)
Interventions
N-Acetyl-L-Leucine, Placebo
Drug · Other
Lead sponsor
IntraBio Inc
Industry
Eligibility
4 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Los Angeles, California • Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Phase 2 Interventional Results available

An Extension Protocol to Evaluate Dose Comparisons of Leucine-Metformin Combinations in Type 2 Diabetic Patients

NCT02435277
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Low Metformin, Mid Metformin, High Metformin, Metformin
Drug
Lead sponsor
NuSirt Biopharma
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
9
States / cities
Chino, California • Palm Beach, Florida • Tampa, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Sep 6, 2026, 5:19 AM EDT
Completed No phase listed Observational

Protein Synthesis in the Brain of Patients With Fragile X Syndrome

NCT00362843
View directory record Official record
Conditions
Fragile X Syndrome, Healthy Volunteers
Interventions
[15-O]water
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 24 Years · Male only
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dileucine and Resistance Training Adaptations

NCT06121869
View directory record Official record
Conditions
Hypertrophy, Strength Training Adaptations, Weight-Bearing Strengthening Program
Interventions
Placebo, Leucine, Dileucine
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 39 Years · Male only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolic Processes in Adults and Adolescents With Autism Spectrum Disorder

NCT02733120
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
stable isotope infusion
Other
Lead sponsor
Texas A&M University
Other
Eligibility
16 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients

NCT01211717
View directory record Official record
Conditions
Type 2 Diabetes, Healthy Individuals
Interventions
Branched Chained Amino Acids, Cellulose Placebo mix
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
20 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2011 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Phase 3 Interventional Results available

SYD985 vs. Physician's Choice in Participants With HER2-positive Locally Advanced or Metastatic Breast Cancer

NCT03262935
View directory record Official record
Conditions
Metastatic Breast Cancer
Interventions
(vic-)trastuzumab duocarmazine, Physician's choice
Drug
Lead sponsor
Byondis B.V.
Industry
Eligibility
18 Years and older · Female only
Enrollment
437 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
23
States / cities
Mobile, Alabama • Tucson, Arizona • San Diego, California + 17 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional

SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI

NCT04603443
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Branched Chain Amino Acids, Protein Control
Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 6, 2026, 5:19 AM EDT
Recruiting Phase 2 Interventional

Leucine in Midlife Depression

NCT06580145
View directory record Official record
Conditions
Major Depression
Interventions
L-leucine, L-lysine
Drug
Lead sponsor
Emory University
Other
Eligibility
35 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses

NCT07121010
View directory record Official record
Conditions
Cardiometabolic Health
Interventions
Animal-Based Protein Smoothie, Plant-Based Protein Smoothie, Plant-Based Protein Smoothie with Leucine
Dietary Supplement
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Estrogen and Serotonin on Changing Brain Chemistry

NCT01208324
View directory record Official record
Conditions
Menopause
Interventions
estrogen patch, Amino acids, Placebo Patch, Placebo pills
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
48 Years to 60 Years · Female only
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers

NCT01005862
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
PF-04360365, Placebo
Biological · Drug
Lead sponsor
Pfizer
Industry
Eligibility
21 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Glendale, California • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 25, 2012 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolic Effects of Perimenopause

NCT06098183
View directory record Official record
Conditions
Perimenopausal Disorder
Interventions
Whey Protein Isolate, Non-caloric Placebo water
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
38 Years to 60 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Muscle Protein Synthesis in Dialysis Patients

NCT03478722
View directory record Official record
Conditions
Muscle Loss
Interventions
Protein Meal, Stable Isotope Amino Acid Infusion
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
20 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 6, 2026, 5:19 AM EDT
Recruiting Not applicable Interventional

Protein Supplementation After ACL Surgery

NCT06311058
View directory record Official record
Conditions
ACL Reconstruction
Interventions
Whey protein isolate, Protein + BAA, Placebo
Dietary Supplement
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
16 Years to 40 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

NCT00760383
View directory record Official record
Conditions
Osteoarthritis
Interventions
Essential amino acids, Alanine
Dietary Supplement
Lead sponsor
University of Oregon
Other
Eligibility
60 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Live Attenuated ETEC Vaccine ACE527 With and Without dmLT Adjuvant in Adults

NCT01739231
View directory record Official record
Conditions
Diarrhea
Interventions
ACE527, dmLT, CeraVacx placebo, H10407 challenge strain
Biological
Lead sponsor
PATH
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 6, 2026, 5:19 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

: Vascular Function in Health and Disease

NCT02966665
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure, Hypertension
Interventions
Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123, Fexofenadine, Ranitidine, Angiotensin-II, Valsartan, Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine, BQ-123, MitoQ, BH4
Other · Drug
Lead sponsor
Russell Richardson
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Recruiting Phase 2 Interventional

SMART Diets for MASLD

NCT07459504
View directory record Official record
Conditions
Metabolic-dysfunction Associated Steatotic Liver Disease
Interventions
Essential Amino Acids Supplementation intervention, Low sugar diet
Drug · Other
Lead sponsor
Michigan State University
Other
Eligibility
11 Years to 17 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 6, 2026, 5:19 AM EDT
Withdrawn Not applicable Interventional

Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial

NCT06579391
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Essential amino acids, Alanine
Dietary Supplement
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 6, 2026, 5:19 AM EDT
Recruiting Not applicable Interventional

PKU Protein Requirements

NCT07194993
View directory record Official record
Conditions
PKU
Interventions
Nonradioactive stable oral isotope, Test diet
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 6, 2026, 5:19 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Vitamin B6 Effects for Women Taking Birth Control Pills

NCT01128244
View directory record Official record
Conditions
Vitamin B6 Deficiency
Interventions
Vitamin B6, Infusion of labeled serine, methionine and leucine
Dietary Supplement · Procedure
Lead sponsor
University of Florida
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Sep 6, 2026, 5:19 AM EDT
Completed No phase listed Observational

PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

NCT01536821
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
9
States / cities
Weston, Florida • Indianapolis, Indiana • Iowa City, Iowa + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2013 · Synced Sep 6, 2026, 5:19 AM EDT