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ClinicalTrials.gov public records Last synced Nov 9, 2026, 4:23 AM EST

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Showing 1–3 of 3 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: LEGION OXINIUM Clear all
Withdrawn Not applicable Interventional

LEGION™ Revision Metal Hypersensitivity Study

NCT02412813
View directory record Official record
Conditions
Total Knee Replacement Revision
Interventions
LEGION OXINIUM, LEGION Cobalt Chrome
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
2
States / cities
Egg Harbor, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2016 · Synced Nov 9, 2026, 4:23 AM EST
Active, not recruiting No phase listed Observational

Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts

NCT03687593
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Legion™ CR Oxinium and CoCr Femoral Implants combined with Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
4
States / cities
Edina, Minnesota • Reno, Nevada • Greenville, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Nov 9, 2026, 4:23 AM EST
Recruiting No phase listed Observational

A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)

NCT07199738
View directory record Official record
Conditions
Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
Interventions
Cemented CoCr, Cemented Oxinium, Cementless
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2036
U.S. locations
4
States / cities
Newton, Massachusetts • New York, New York • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Nov 9, 2026, 4:23 AM EST