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ClinicalTrials.gov public records Last synced Oct 25, 2026, 1:45 PM EDT

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Showing 49–72 of 81 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: LPS Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

NCT00854295
View directory record Official record
Conditions
Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities
Interventions
NexGen LPS-Flex Mobile Bearing Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2021
U.S. locations
3
States / cities
Tamarac, Florida • Auburn Hills, Michigan • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Oct 25, 2026, 1:45 PM EDT
No Longer Available No phase listed Expanded access

Single-Patient Expanded Access Protocol - RNA-LP in a Patient With Recurrent Osteosarcoma

NCT07560709
View directory record Official record
Conditions
Recurrent Osteosarcoma
Interventions
pp65/tumor mRNA RNA-LP
Biological
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 17 Years · Male only
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 25, 2026, 1:45 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?

NCT03104725
View directory record Official record
Conditions
Parkinson Disease, Cerebrospinal Fluid
Interventions
N-Acetylcysteine, Lumbar Puncture, Fluoroscopy
Drug · Procedure · Radiation
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Oct 25, 2026, 1:45 PM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma

NCT06270576
View directory record Official record
Conditions
Asthma; Eosinophilic, Asthma
Interventions
Lipopolysaccharides
Drug
Lead sponsor
National Jewish Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Role of TLR4 in Environmental Asthma

NCT00671892
View directory record Official record
Conditions
Asthma
Interventions
Lipopolysaccharide endotoxin
Biological
Lead sponsor
John Sundy
Other
Eligibility
18 Years to 40 Years
Enrollment
855 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 16, 2013 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Results available

Lipopolysaccharide (LPS) Challenge in Depression

NCT03142919
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Lipopolysaccharide, Placebo
Biological
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 25, 2026, 1:45 PM EDT
Recruiting Phase 1Phase 2 Interventional

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

NCT04577014
View directory record Official record
Conditions
Soft Tissue Sarcoma, Sarcoma,Soft Tissue, Sarcoma, Soft Tissue Sarcoma Adult
Interventions
Retifanlimab, Gemcitabine, Docetaxel
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 25, 2026, 1:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Nitric Oxide, LPS and the Pathogenesis of Asthma Phase 1

NCT00671229
View directory record Official record
Conditions
Healthy, Asthma
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 40 Years
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Immunogenicity of Recombinant Envelope Protein rgp120/HIV-1SF2 (BIOCINE) Combined With Seven Adjuvants in Healthy HIV-1 Uninfected Individuals

NCT00001042
View directory record Official record
Conditions
HIV Infections
Interventions
Aluminum hydroxide, Lipid A, Monophosphoryl, Lipid A, Liposome-encapsulated monophosphoryl, Syntex adjuvant formulation, MF59, Threonyl Muramyl Dipeptide, rgp120/HIV-1 SF-2, MTP-PE/MF59
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 60 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 1996
U.S. locations
3
States / cities
St Louis, Missouri • Rochester, New York • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Inflammation and the Host Response to Injury (In Healthy Volunteers)

NCT00820989
View directory record Official record
Conditions
Immune System
Interventions
Endotoxin, Lipopolysaccharide, LPS
Biological
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 40 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2011
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced Oct 25, 2026, 1:45 PM EDT
Terminated Phase 2 Interventional Results available

ATX-101 in Advanced Dedifferentiated Liposarcoma and Leiomyosarcoma

NCT05116683
View directory record Official record
Conditions
Leiomyosarcoma, Liposarcoma
Interventions
ATX-101
Drug
Lead sponsor
Benjamin Izar
Other
Eligibility
18 Years to 99 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Results available

Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal Tumors

NCT05751837
View directory record Official record
Conditions
Abdominal Cancer, Malignancy
Interventions
Lipopolysaccharide
Biological
Lead sponsor
Patrick Wagner, MD, FACS
Other
Eligibility
18 Years to 99 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS

NCT02104505
View directory record Official record
Conditions
Mild, Allergic Asthma
Interventions
Gamma Tocopherol 700 mg capsules,, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 25, 2026, 1:45 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers Results available

Leucine for Depression Study (L-DEP)

NCT03557684
View directory record Official record
Conditions
Depression
Interventions
leucine, PO placebo, lipopolysaccharide (LPS), IV placebo
Dietary Supplement · Other · Biological
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Oct 25, 2026, 1:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

NCT03938870
View directory record Official record
Conditions
Alzheimer's Disease, Brain Diseases, Central Nervous System Diseases, Delirium, Dementia, Amnestic, Cognitive Disorders, Dementia, Mental Disorders, Nervous System Diseases, Neurodegenerative Diseases, Tauopathies
Interventions
L-Leucine 13C6
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effects of Epinephrine in Endotoxemia in Normal Volunteers

NCT00753402
View directory record Official record
Conditions
Immune System
Interventions
Endotoxin, Lipopolysaccharide, LPS, Endotoxin, Epinephrine
Biological
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 40 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of a 10,000 EU Dose of Endotoxin in Allergic and Mildly Asthmatic Adults

NCT00839189
View directory record Official record
Conditions
Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, Asthma
Interventions
Clinical Center Reference Endotoxin (CCRE)
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 9, 2009 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Quantifying Airway Inflammation With Radiologic Tests

NCT00741013
View directory record Official record
Conditions
Lung Inflammation
Interventions
placebo pill and placebo IV, Lovastatin pill and placebo IV, placebo pill and recombinant human activated protein C IV, Endotoxin
Drug · Biological
Lead sponsor
Washington University School of Medicine
Other
Eligibility
19 Years to 44 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 26, 2014 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 1 Interventional

Vaccination of HIV-1 Infected Patients With Dendritic Cells in Addition to Antiretroviral Treatment - (DALIA Trial)

NCT00796770
View directory record Official record
Conditions
HIV
Interventions
Dendritic Cell Vaccine
Biological
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Not applicable Interventional Results available

Assessment of Laryngopharyngeal Sensation in Adductor Spasmodic Dysphonia

NCT05158179
View directory record Official record
Conditions
Spasmodic Dysphonia, Adductor Spasmodic Dysphonia, Voice Disorders
Interventions
Sensation testing
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 85 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2024 · Synced Oct 25, 2026, 1:45 PM EDT
Completed No phase listed Observational

10003 PRO Current Products

NCT01497730
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
842 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
11
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Oct 25, 2026, 1:45 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Response of Airway Cells to 20,000 EU of Endotoxin in Normal Adults

NCT00838851
View directory record Official record
Conditions
Healthy Controls
Interventions
Clinical Center Reference Endotoxin (CCRE)
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 8, 2012 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia

NCT04263454
View directory record Official record
Conditions
Fibromyalgia
Interventions
Endotoxin, Escherichia Coli, Magnetic Resonance Spectroscopy
Drug · Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 25, 2026, 1:45 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Dose Response Effects of Marine Omega-3 Fatty Acids on Inflammation

NCT01078909
View directory record Official record
Conditions
Cardiovascular Disease, Inflammation
Interventions
Eicosapentaenoic Acid and Docosahexaenoic Acid (EPA + DHA)
Biological
Lead sponsor
Penn State University
Other
Eligibility
20 Years to 45 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Oct 25, 2026, 1:45 PM EDT