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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:05 AM EDT

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Showing 1–24 of 94 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Lactobacillus Probiotic Capsule Clear all
Completed Phase 1Phase 2 Interventional

Does Weight Loss Surgery and Probiotic Supplementation Lead to a "Lean" Gut Microbiota?

NCT01870544
View directory record Official record
Conditions
Obesity
Interventions
Lactobacillus Rhamnosus GG, Placebo
Dietary Supplement
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 10, 2016 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Results available

Impact of Probiotics for Reducing Infections in Veterans: The IMPROVE Study

NCT01321606
View directory record Official record
Conditions
Anti-biotic Resistance
Interventions
Lactobacillus rhamnosus HN001, sugar pill (placebo)
Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 3, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Detection of Probiotic Strains in Vaginal Swabs Collected From Healthy Women

NCT04719611
View directory record Official record
Conditions
Healthy
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Lallemand Health Solutions
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 3 Interventional

Lactobacillus GG in the Prophylaxis of Ventilator Associated Pneumonia

NCT00613795
View directory record Official record
Conditions
Pneumonia, Ventilator Associated Pneumonia
Interventions
Lactobacillus GG, placebo
Dietary Supplement
Lead sponsor
Creighton University
Other
Eligibility
19 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 18, 2010 · Synced Oct 22, 2026, 10:05 AM EDT
Withdrawn Not applicable Interventional

Monitoring the Effects of Probiotic Supplementation in Immunocompromised Kidney Transplanted Subjects

NCT05102461
View directory record Official record
Conditions
Diarrhea Caused by Drug, Dysbiosis
Interventions
Florajen Digestion Supplementation, Placebo Supplementation
Dietary Supplement
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotic on Psychological and Cognitive Effects

NCT03080818
View directory record Official record
Conditions
Aging
Interventions
Probiotic - Lactobacillus Rhamnosus GG, Placebo
Dietary Supplement · Other
Lead sponsor
Kent State University
Other
Eligibility
55 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Kent, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

The Effects of a High Protein Diet on Microbiota, Gastrointestinal Function and Wellness in Older Women

NCT02445560
View directory record Official record
Conditions
Aging
Interventions
Probiotic capsule and Fiber Sachet, Probiotic capsule and Placebo sachet, Placebo capsule and Fiber Sachet, Placebo capsule and Placebo sachet
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
65 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
2
States / cities
Gainesville, Florida • Ocala, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Clinical Trial Evaluating the Viability of L. Casei + Fish Oil Capsules

NCT01464814
View directory record Official record
Conditions
Signs and Symptoms, Digestive
Interventions
probiotic plus fish oil capsule, Fish oil capsule
Dietary Supplement
Lead sponsor
Nutrition 21, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Pembroke Pines, Florida
Source: ClinicalTrials.gov public record
Updated Nov 16, 2011 · Synced Oct 22, 2026, 10:05 AM EDT
Active, not recruiting Phase 2 Interventional

Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters

NCT04323735
View directory record Official record
Conditions
Neurogenic Bladder
Interventions
Culturelle 10 Billion CFU Capsule
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Safety, Tolerability and Host Response to Lactobacillus Johnsonii

NCT02349360
View directory record Official record
Conditions
Healthy
Interventions
L. johnsonii N6.2, Placebo
Biological
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 50 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Results available

Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB

NCT02748317
View directory record Official record
Conditions
Lower Urinary Tract Symptoms
Interventions
Lactobacillus rhamnosus GG
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Placebo Controlled Pilot Study of Probiotic Supplementation in At-risk Pregnant Women

NCT03646487
View directory record Official record
Conditions
Iron-deficiency, Pregnancy, High Risk, Stress, Psychological
Interventions
Probiotic LP299v 10x10 colony forming units in capsule form, Placebo in capsule form
Dietary Supplement · Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 7, 2023 · Synced Oct 22, 2026, 10:05 AM EDT
Terminated Not applicable Interventional

The Effects of Probiotic Supplementation on Extremely Low Birthweight Infants

NCT01788761
View directory record Official record
Conditions
Feeding Tolerance
Interventions
Probiotic Supplemented Group, Control Group
Dietary Supplement
Lead sponsor
Mercy Health System
Network
Eligibility
Up to 14 Days
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Rockford, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Phase 2 Interventional

LGG Supplementation in Patients With AUD and ALD

NCT05178069
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol-associated Liver Disease
Interventions
: Placebo for Probiotic, Lactobacillus Rhamnosus GG
Drug · Dietary Supplement
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 22, 2026, 10:05 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Probiotics for Prevention of Antibiotic Associated Diarrhea and Clostridium Difficile Associated Disease

NCT02076438
View directory record Official record
Conditions
Diarrhea
Interventions
Probiotics
Dietary Supplement
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 89 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 23, 2016 · Synced Oct 22, 2026, 10:05 AM EDT
Not listed Not applicable Interventional

Effects of a Multispecies Probiotic on Migraine

NCT04696458
View directory record Official record
Conditions
Migraine, Irritable Bowel Syndrome, Headache, Migraine
Interventions
Lactobacillus plantarum (CECT7484 and CECT7485)/ Pediococcus acidilactici (CECT7483), Placebo Comparator: Placebo
Dietary Supplement · Other
Lead sponsor
Scripps Health
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2022 · Synced Oct 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

NCT05517928
View directory record Official record
Conditions
Healthy
Interventions
Omeprazole, Lactobacillus rhamnosus GG, Placebo
Drug · Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Pilot Study Lp299v Supplementation in Chronic Heart Failure

NCT05752760
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic
Interventions
Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
21 Years to 89 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy

NCT01479478
View directory record Official record
Conditions
Infection, Pregnancy
Interventions
Placebo, Probiotic dietary supplement
Drug · Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
3
States / cities
Aptos, California • Santa Cruz, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Active, not recruiting Not applicable Interventional

Impact of Lp299v on Vascular Function in Patients With PASC

NCT05227170
View directory record Official record
Conditions
COVID-19
Interventions
Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Probiotics to Aid in Weight Loss

NCT01445704
View directory record Official record
Conditions
Weight Loss
Interventions
Probiotics, Placebo
Dietary Supplement
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2014 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 4 Interventional

Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

NCT02462590
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea, Diarrhea
Interventions
L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
2,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers

Trenev Trio/Healthy Trinity for Symptoms of Diarrhea-predominant Irritable Bowel Syndrome (IBS) and Functional Dyspepsia

NCT01268618
View directory record Official record
Conditions
IBS-D and Functional Dyspepsia
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
Sprim Advanced Life Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
2
States / cities
Duluth, Georgia • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2011 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prenatal Probiotic Intervention

NCT03240419
View directory record Official record
Conditions
Childhood Obesity, Maternal Obesity During Childbirth, Insulin Resistance, Inflammation
Interventions
Probiotics, Placebo
Dietary Supplement
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Oct 22, 2026, 10:05 AM EDT