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ClinicalTrials.gov public records Last synced Sep 3, 2026, 5:29 PM EDT

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Large Language Model Clear all
Recruiting Not applicable Interventional

BRIDGE-SIC Efficacy Trial

NCT07735442
View directory record Official record
Conditions
Cancer
Interventions
LLM-generated SIC summary email to clinical teams
Behavioral
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Language Evaluation With AI for Residents

NCT07222644
View directory record Official record
Conditions
Patient Communication
Interventions
educational LLM-based feedback tool
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models

NCT06588452
View directory record Official record
Conditions
Comparing Manual and AI Patient Screening in Heart Failure
Interventions
RECTIFIER - a generative artificial intelligence screening tool, Manual clinical trial screening by study staff
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
4,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial

NCT07107152
View directory record Official record
Conditions
Colorectal Cancer Control and Prevention
Interventions
single GPT generated message, AI Chatbot, Expert-Written Patient Materials
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 75 Years
Enrollment
915 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional

Ambient AI Clinical Trial

NCT07598721
View directory record Official record
Conditions
Artificial Intelligence (AI), Physician Burnout, Physician Work Environment
Interventions
Use of Ambient AI scribe tool on participant's mobile device
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support

NCT07037940
View directory record Official record
Conditions
Large Language Models
Interventions
OpenEvidence, GPT-4
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
25 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
2
States / cities
Boston, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional

RENEW-AI: Personalizing Scleroderma Management With an AI Health Coach

NCT06999226
View directory record Official record
Conditions
Scleroderma
Interventions
RENEW-AI
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diagnostic Reasoning With Customized GPT-4 Model

NCT06911645
View directory record Official record
Conditions
Pathologic Processes, Disease
Interventions
Immediate access to customized version of GPT-4, Access to customized version of GPT-4 following use of conventional resources
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Recruiting Not applicable Interventional

Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models

NCT06002425
View directory record Official record
Conditions
Gastrointestinal Neoplasm Malignant
Interventions
Clinician-Directed Treatment Plan, ChatGPT-Assisted Treatment Plan
Other
Lead sponsor
Chinese Academy of Sciences
Government
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Sep 3, 2026, 5:29 PM EDT
Not yet recruiting Not applicable Interventional

Listen Aphasia Pilot Study

NCT07732140
View directory record Official record
Conditions
Aphasia, Malignant Brain Tumor
Interventions
LISTEN (AI-based AAC smartphone app)
Device
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Active, not recruiting Not applicable Interventional

Testing a Brief Reassurance Message Before a Musculoskeletal Clinic Visit

NCT07330492
View directory record Official record
Conditions
Any Non-traumatic Musculoskeletal Condition
Interventions
Nudge intervention
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

BabaCare: Testing a Care Copilot

NCT07689526
View directory record Official record
Conditions
Loneliness, Mood
Interventions
AI phone companion
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of a Large Language Model-Based Educational Tool on Intraocular Lens Options

NCT07317661
View directory record Official record
Conditions
Eye Disorders, Cataract Extraction, Cataract and IOL Surgery, Cataract Surgery Experience, Cataract Surgery, Intraocular Lens
Interventions
LLM-based Education
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Active, not recruiting Not applicable Interventional

Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care

NCT07022769
View directory record Official record
Conditions
Any Chronic, Non-traumatic Orthopedic Condition
Interventions
LLM-facilitated cognitive debiasing aid
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Recruiting Not applicable Interventional

Large Language Models To Improve the Quality of Care of Cardiology Patients

NCT06935253
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy (HCM), Cardiomyopathy, Genetic Disease, Cardiology
Interventions
Large Language Model
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Recruiting Not applicable Interventional

REmote Symptom COllection to improVE postopeRative Care

NCT06190730
View directory record Official record
Conditions
Gastrointestinal Cancer, Gastrointestinal Tumor, Gastrointestinal Tumor Surgery, Gastrointestinal Surgery
Interventions
Voice-Assisted Remote Symptom Monitoring System (VARSMS)
Other
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
281 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physician Reasoning on Management Cases With Large Language Models

NCT06208423
View directory record Official record
Conditions
Clinical Decision-making
Interventions
GPT-4
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance

NCT05816473
View directory record Official record
Conditions
Gastrointestinal Hemorrhage
Interventions
LLM
Other
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Active, not recruiting Not applicable Interventional

Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients

NCT06778486
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis of the Hip or Knee
Interventions
Artificial Intelligence Chatbot
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional

Using AI to Improve Sepsis Quality of Care in the Emergency Department

NCT07581340
View directory record Official record
Conditions
Sepsis
Interventions
Near-real time automated feedback on SEP-1 performance
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ambient AI for Provider Well-Being

NCT06517082
View directory record Official record
Conditions
Healthcare Provider Well-being
Interventions
Artificial Intelligence
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physician Reasoning on Diagnostic Cases With Large Language Models

NCT06157944
View directory record Official record
Conditions
Diagnosis
Interventions
GPT-4
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Sep 3, 2026, 5:29 PM EDT
Completed Not applicable Interventional

Patient-Executed, Clinician-Confirmed Diuretic Titration in Pulmonary Artery Pressure-Guided Heart Failure (SURPASS-HF)

NCT07743125
View directory record Official record
Conditions
Heart Failure
Interventions
Shared-management diuretic titration guided by remote PA pressure monitoring
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
40 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Menomonee Falls, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 3, 2026, 5:29 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial

NCT07293078
View directory record Official record
Conditions
Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure, Acute Kidney Injury, Delirium Confusional State, Shock
Interventions
Point-of-care large language model decision support (ChatGPT-5)
Other
Lead sponsor
MetroWest Artificial Intelligence Research Workgroup
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Framingham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 3, 2026, 5:29 PM EDT