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ClinicalTrials.gov public records Last synced Oct 20, 2026, 1:58 PM EDT

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Showing 49–72 of 475 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Lazanda Clear all
Completed No phase listed Observational

The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion

NCT00494598
View directory record Official record
Conditions
Aortic Aneurysm
Interventions
Sufentanil
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Oct 20, 2026, 1:58 PM EDT
Recruiting Not applicable Interventional

Harm Reduction Services

NCT05776316
View directory record Official record
Conditions
Drug Use, Substance Abuse, Mental Illness
Interventions
Integrated Harm Reduction Intervention (IHRI)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
New Haven, Connecticut • New York, New York • Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 20, 2026, 1:58 PM EDT
Terminated Phase 4 Interventional Results available

Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE

NCT01005459
View directory record Official record
Conditions
Labor Pain
Interventions
Tetracaine, Bupivacaine
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
12 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 8, 2017 · Synced Oct 20, 2026, 1:58 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE

NCT05873218
View directory record Official record
Conditions
Labor
Interventions
Ephedrine, Normal Saline Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Not applicable Interventional

Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.

NCT02086123
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Epidural Analgesia, Parenteral Analgesia (Intravenous)
Procedure
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 20, 2026, 1:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Anesthetic Optimization in Pediatric LeFort Surgeries

NCT05260320
View directory record Official record
Conditions
Le Fort, Pain, Postoperative
Interventions
Standardized Anesthetic Course from Premedication to Induction
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
14 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 20, 2026, 1:58 PM EDT
Terminated No phase listed Observational

Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients

NCT03925610
View directory record Official record
Conditions
Morbid Obesity, Opioid-Related Disorders, Surgery--Complications, Sleep Apnea Syndromes
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pediatric Pain Optimization After Tonsillectomy

NCT05244226
View directory record Official record
Conditions
Obstructive Sleep Apnea, Tonsillitis, Pain, Procedural
Interventions
Fentanyl/Hydromorphone, Methadone
Drug
Lead sponsor
Duke University
Other
Eligibility
3 Years to 17 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Phase 4 Interventional Results available

Intranasal Fentanyl as an Analgesic for Cystoscopic Procedures

NCT01708122
View directory record Official record
Conditions
Pain
Interventions
Fentanyl, saline
Drug
Lead sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Oct 20, 2026, 1:58 PM EDT
Withdrawn Phase 2Phase 3 Interventional

Postoperative Oral Methadone After Major Spine Surgery; Safety, Feasibility and Efficacy in Prevention of Progression to Chronic Opioid Usage at 3 Months

NCT05693675
View directory record Official record
Conditions
Spine Surgery
Interventions
Postoperative methadone, Postoperative placebo, Rescue Analgesia
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Oct 20, 2026, 1:58 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Intrapartum Epidural Fentanyl and Breastfeeding in the Immediate Postpartum Period: a Randomized, Controlled, Double-blinded Study

NCT01497509
View directory record Official record
Conditions
Neonatal Neurobehavior, Breastfeeding Outcomes
Interventions
Bolus 10mL 0.25% bupivacaine/ep 1:600,000; infusion 10mL/hour 0.25% bupivacaine and epi 1:800,000, Bolus 10mL 0.25% bupivacaine/ epinephrine 1:600,000;infusion 10mL/hour 0.25% bupivacaine, 2 mcg/mL fentanyl, and epinephrine 1:800,000, Bolus 10mL 0.25% bupivacaine, 10mcg/mL fentanyl, and epi 1:600,000; infusion 10mL/hour 0.25% bupivacaine, 2.5 mcg/mL fentanyl, and epi 1:800,000, Bolus 10mL 0.25% bupivacaine, 5 mcg/mL fentanyl, and epi 1:600,000; infusion 10mL/hour 0.25% bupivacaine, 3.5 mcg/mL fentanyl, and epi 1:800,000
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 18, 2022 · Synced Oct 20, 2026, 1:58 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Study of the Effect of Clinical Procedures on Drug Delivery of Mylan Fentanyl Transdermal System 25 µg/hr and Duragesic® 25 µg/hr

NCT00648414
View directory record Official record
Conditions
Healthy
Interventions
Mylan Fentanyl Transdermal System 25 mcg/h + Clinical Procedure 1, Mylan Fentanyl Transdermal System 25 mcg/h + Clinical Procedure 2, Mylan Fentanyl Transdermal System 25 mcg/h + Clinical Procedure 3, Duragesic 25 mcg/h + Clinical Procedure 1, Duragesic 25 mcg/h + Clinical Procedure 2, Duragesic 25 mcg/h + Clinical Procedure 3
Drug
Lead sponsor
Mylan Pharmaceuticals Inc
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced Oct 20, 2026, 1:58 PM EDT
Terminated Phase 4 Interventional Results available

Impact of Methadone on Prolonged Mechanical Ventilation in Patients on Continuous Treatment With Opioids

NCT06110546
View directory record Official record
Conditions
Effect of Methadone on the Duration on Mechanical Ventilation
Interventions
Methadone group, Usual care
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Phase 4 Interventional Results available

Comparing Effectiveness of CSE Versus DPE for Labor Analgesia

NCT05068661
View directory record Official record
Conditions
Labor Pain
Interventions
Ropivacaine 0.1% Injectable Solution, Bupivacaine 0.25% Injectable Solution
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 6, 2024 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Phase 1 Interventional

Methadone Pharmacokinetics and Cardiac Effects in Newborns

NCT00715988
View directory record Official record
Conditions
Pain
Interventions
Methadone HCl Inject 10 mg/ml (will require dilution), Methadone
Drug
Lead sponsor
University of Utah
Other
Eligibility
29 Weeks to 48 Weeks
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2017
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 1, 2022 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Sedation Regimens in GI Endoscopy

NCT04807101
View directory record Official record
Conditions
Anesthesia, Endoscopy, Colonoscopy, Conscious Sedation
Interventions
midazolam alone
Drug
Lead sponsor
Greg S Cohen MD LLC
Other
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Oct 20, 2026, 1:58 PM EDT
Terminated Phase 4 Interventional Results available

Lusedra (Fospropofol Disodium) for Minimal to Moderate Sedation for Regional Anesthesia Block Prior to Orthopedic Surgery

NCT01195103
View directory record Official record
Conditions
Procedural Sedation, Regional Anesthesia Block, Orthopedic Surgery
Interventions
Fospropofol disodium, Placebo + Midazolam, Fentanyl
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 29, 2012 · Synced Oct 20, 2026, 1:58 PM EDT
Not listed Phase 4 Interventional

Comparison of Intrathecal Versus Epidural Fentanyl on Fetal Bradycardia in Labor Combined Spinal Epidural Analgesia

NCT03623256
View directory record Official record
Conditions
Labor Pain, Obstetric Pain
Interventions
Spinal fentanyl, Spinal bupivacaine, Spinal Fentanyl and Bupivacaine, Epidural fentanyl /spinal bupivacaine
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older · Female only
Enrollment
558 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Lazanda Fentanyl Nasal Spray Pre Radiofrequency Nerve Ablations(RFA) of Lumbar Facet Joints

NCT02571634
View directory record Official record
Conditions
Minor Procedural Pain
Interventions
Lazanda
Drug
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Oct 20, 2026, 1:58 PM EDT
Terminated Phase 2 Interventional Results available

Dose Finding Posterolateral Thoracotomy Study

NCT00807209
View directory record Official record
Conditions
Postoperative Pain
Interventions
Low Dose SKY0402, High Dose SKY0402, Placebo, Fentanyl via PCA, Bupivacaine via epidural
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
5
States / cities
Pasadena, California • Orlando, Florida • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated May 15, 2012 · Synced Oct 20, 2026, 1:58 PM EDT
Recruiting Not applicable Interventional

Analgesia-First Sedation in Trauma Patients

NCT05751863
View directory record Official record
Conditions
Mechanical Ventilation, Respiratory Failure
Interventions
Analgesia First Sedation Strategy for Mechanically Ventilated (MV) Trauma Subjects, Protocol Directed Sedation and Daily Sedation Interruption
Other
Lead sponsor
MemorialCare Health System
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Oct 20, 2026, 1:58 PM EDT
Recruiting Phase 4 Interventional

Patient Preference and Long-term Outcomes in Persistent Spinal Pain Syndrome: A Prospective Study Comparing Spinal Cord Stimulation to Intrathecal Drug Delivery.

NCT07091123
View directory record Official record
Conditions
Persistent Spinal Pain Syndrome
Interventions
Pain pump, Bupivacain 0.625%/Fentanyl 2mcg/ml, Spinal Cord Stimulator (SCS)
Device · Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
30 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 20, 2026, 1:58 PM EDT
Completed Phase 3 Interventional Results available

A Trial Evaluating the Efficacy and Safety of the Sublingual Sufentanil Tablet 30 mcg for Post-Operative Pain After Abdominal Surgery

NCT02356588
View directory record Official record
Conditions
Post-Operative Pain
Interventions
Sufentanil Tablet 30 mcg, Placebo Tablet
Drug
Lead sponsor
Talphera, Inc
Industry
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
4
States / cities
Sheffield, Alabama • Pasadena, California • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2017 · Synced Oct 20, 2026, 1:58 PM EDT
Completed No phase listed Observational

Effect of Opioid Shortage on Drug Selection

NCT04099030
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
1,668 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2020 · Synced Oct 20, 2026, 1:58 PM EDT