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ClinicalTrials.gov public records Last synced Oct 6, 2026, 10:03 PM EDT

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Showing 121–144 of 340 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Leg sham therapy Clear all
Not listed Not applicable Interventional

KITAMS: Kinesio Tape and Physical Function in Persons With Multiples Sclerosis

NCT03804047
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
kinesio tape
Other
Lead sponsor
Northern Illinois University
Other
Eligibility
18 Years to 50 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
DeKalb, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 6, 2026, 10:03 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

NCT06319339
View directory record Official record
Conditions
Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
Interventions
Vumerity, Placebo
Drug · Other
Lead sponsor
University of Nebraska
Other
Eligibility
50 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication

NCT00117650
View directory record Official record
Conditions
Intermittent Claudication, Peripheral Vascular Disease, Atherosclerosis
Interventions
Ad2/HIF-1α/VP16, Saline (Placebo Control)
Biological · Other
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
40 Years to 80 Years
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
35
States / cities
Birmingham, Alabama • Palo Alto, California • Sacramento, California + 28 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2015 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 4 Interventional Results available

Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

NCT01824082
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Perineural infusion [continuous peripheral nerve block(s)]
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
4
States / cities
Palo Alto, California • San Diego, California • Bethesda, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Not applicable Interventional Results available

Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury

NCT01272011
View directory record Official record
Conditions
Spinal Cord Injuries, Brown Sequard, Central Cord Syndrome
Interventions
Intermittent Hypoxia, Locomotor Training
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2016 · Synced Oct 6, 2026, 10:03 PM EDT
Terminated Phase 2Phase 3 Interventional

Safety and Efficacy of Rasagiline in Restless Legs Syndrome

NCT01192503
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
rasagiline, placebo (sugar pill)
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
8
States / cities
Pinellas Park, Florida • Augusta, Georgia • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2013 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 3 Interventional Results available

Converting From Ropinirole Immediate Release (IR) To Ropinirole Controlled-Release for RLS (Restless Legs Syndrome)

NCT00256854
View directory record Official record
Conditions
Restless Legs Syndrome, Restless Legs Syndrome (RLS)
Interventions
Ropinirole IR 1 mg, Ropinirole IR 2 mg, Ropinirole IR 1 mg Placebo, Ropinirole IR 2 mg Placebo, Ropinirole CR 2 mg, Ropinirole CR 3 mg, Ropinirole CR 2 mg Placebo, Ropinirole CR 3 mg Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 79 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
30
States / cities
Laguna Hills, California • Oxnard, California • Pasadena, California + 27 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2019 · Synced Oct 6, 2026, 10:03 PM EDT
Withdrawn Phase 4 Interventional

Pregabalin (Lyrica) for the Treatment of Restless Legs Syndrome

NCT00584246
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
Pregabalin (Lyrica), Placebo
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 16, 2021 · Synced Oct 6, 2026, 10:03 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Sympatholysis in Chronic Kidney Disease

NCT02411773
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Sodium Bicarbonate, Placebo, Exercise Training, Control to Exercise (Stretching)
Drug · Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 75 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition

NCT02143817
View directory record Official record
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
L-citrulline supplementation, Whole Body Vibration Training
Dietary Supplement · Other
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 10, 2015 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 3 Interventional

A Clinical Research Study Evaluating Ropinirole Treatment For Restless Legs Syndrome (RLS)

NCT00225862
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
ropinirole
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 79 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
37
States / cities
Alabaster, Alabama • Jasper, Alabama • Peoria, Arizona + 33 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Oct 6, 2026, 10:03 PM EDT
Terminated Not applicable Interventional Results available

Building Strength Through Rehabilitation for Heart Failure Patients (BISTRO-STUDY)

NCT03615469
View directory record Official record
Conditions
Heart Failure
Interventions
Transcutaneous electrical stimulation, Neuromuscular electrical stimulation
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 2 Interventional

Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome

NCT00199446
View directory record Official record
Conditions
Sleep Disorder, Restless Legs Syndrome
Interventions
Istradefylline (KW-6002)
Drug
Lead sponsor
Kyowa Kirin, Inc.
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Not applicable Interventional

Preconditioning With Limb Ischemia for Subarachnoid Hemorrhage

NCT02411266
View directory record Official record
Conditions
Ischemic Preconditioning
Interventions
ischemic conditioning group
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 13, 2021 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 4 Interventional

12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome

NCT00373542
View directory record Official record
Conditions
Restless Legs Syndrome (RLS), Restless Legs Syndrome
Interventions
ropinirole CR-RLS
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 79 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
45
States / cities
Jasper, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 41 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2016 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 2 Interventional

Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia

NCT00721006
View directory record Official record
Conditions
Critical Limb Ischemia, Severe Leg Ischemia, Peripheral Artery Disease, Peripheral Vascular Disease
Interventions
MESENDO, Placebo
Biological
Lead sponsor
TCA Cellular Therapy
Industry
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Covington, Louisiana
Source: ClinicalTrials.gov public record
Updated May 9, 2014 · Synced Oct 6, 2026, 10:03 PM EDT
Terminated Phase 4 Interventional Results available

A Study of Loco-Regional Liposomal Bupivacaine Injection

NCT05992896
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Bupivacaine liposome, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Eau Claire, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 6, 2026, 10:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Therapy in Lower Limb Extensor Injuries

NCT04149977
View directory record Official record
Conditions
Lower Limb Injury
Interventions
Physical Therapy with pressure cuff, Physical Therapy with placebo pressure cuff
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 6, 2026, 10:03 PM EDT
Recruiting Phase 2 Interventional

MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes

NCT06930638
View directory record Official record
Conditions
Stroke
Interventions
Ischemic Conditioning, Antioxidant Supplement
Device · Dietary Supplement
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 4 Interventional

A 6 Week Trial to Study the Efficacy and Safety of a Starting Dose 0.25 mg Pramipexole (Mirapex) in Patients With RLS

NCT00375284
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
Pramipexole
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 80 Years
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
52
States / cities
Birmingham, Alabama • Dothan, Alabama • Mesa, Arizona + 47 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2013 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Lower Limb Function After Spinal Cord Injury

NCT02635893
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
D-Cycloserine, Placebo, Training, Stimulation, Placebo Stimulation
Drug · Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 85 Years
Enrollment
257 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 2 Interventional Results available

Intravenous Iron Metabolism in Restless Legs Syndrome

NCT00685815
View directory record Official record
Conditions
Restless Legs
Interventions
Ferric Carboxymaltose (FCM), Placebo
Drug
Lead sponsor
American Regent, Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Botulinum Toxin to Treat Restless Legs Syndrome

NCT00479154
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
Botulinum Toxin A
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 26, 2012 · Synced Oct 6, 2026, 10:03 PM EDT
Completed Phase 2 Interventional Results available

Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA)

NCT02700529
View directory record Official record
Conditions
Lymphedema
Interventions
ubenimex, placebo
Drug · Other
Lead sponsor
Eiger BioPharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
3
States / cities
Stanford, California • Orlando, Florida • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Oct 6, 2026, 10:03 PM EDT