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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:45 AM EST

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Showing 1–24 of 116 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Lidocaine infusion Clear all

Conditions: Metabolic Syndrome
Interventions: intravenous glucose tolerance test, testosterone, anastrozole, goserelin acetate implant, aerobic capacity (VO2 Max), MRI, muscle biopsy, measurement of resting metabolic rate (energy expenditure), Dual energy x-ray absorptiometry, Fasting oral glucose tolerance test; Procedure · Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 50 Years to 75 Years · Male only
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 2
States / cities: Baltimore, Maryland • Boston, Massachusetts

Conditions: Abdominal Hysterectomy (& Wertheim)
Interventions: Lidocaine, Placebo, Ketamine, Ketamine + Lidocaine; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Mayfield Heights, Ohio

Conditions: Postoperative Pain
Interventions: Lidocaine, Ketamine, Saline; Drug · Other
Lead sponsor: Beth Israel Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Colorectal Disorders
Interventions: Exparel, IV Lidocaine; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 75 Years
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Migraine
Interventions: Lidocaine (drug), Lidocaine Procedure; Drug · Procedure
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Great Neck, New York

Conditions: Pancreatectomy
Interventions: Lidocaine, Placebo D5W; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Diabetes, Peripheral Neuropathy, Pain
Interventions: lidocaine, Placebo; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Endometriosis
Interventions: IV Lidocaine, IV diphenhydramine; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Post Operative Pain
Interventions: Lidocaine Hydrochloride, Placebo; Drug · Other
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Rib Fractures
Interventions: Lidocaine IV Infusion, 2% Lidocaine via ESPB; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Rib Fractures
Interventions: Saline infusion, Lidocaine infusion; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Stanford, California

Conditions: Rib Fractures
Interventions: Cryoablation, ESP Catheter; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Pain
Interventions: lidocaine hydrochloride; Drug
Lead sponsor: Lahey Clinic; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Burlington, Massachusetts

Conditions: Pain
Interventions: Lidocaine, Sterile Saline; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 2
States / cities: Portland, Oregon

Conditions: Chronic Pain Syndrome
Interventions: Lidocaine IV; Drug
Lead sponsor: International Spine, Pain and Performance Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Pain
Interventions: Lidocaine; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Cocaine Addiction
Interventions: lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline; Drug
Lead sponsor: Bryon Adinoff; Other
Eligibility: 25 Years to 60 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Analgesia
Interventions: Depodur, Fentanyl; Drug
Lead sponsor: Goodman, Evan, M.D.; Individual
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Chronic Pain
Interventions: Lidocaine infusion, Saline infusion; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 2
States / cities: Dallas, Texas

Conditions: Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
Interventions: EEG Monitoring, Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol; Device · Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain
Interventions: Lidocaine, Placebo (normal saline); Drug · Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Arthroplasty, Replacement, Knee, Total Knee Arthroplasty
Interventions: Lidocaine IV, Saline IV; Drug
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years to 80 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Pain, Obesity
Interventions: Lidocaine Infusion, Normal Saline; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Renal Failure Chronic Requiring Hemodialysis, Chronic Renal Insufficiency
Interventions: VectorFlow TDC, Palindrome TDC; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

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Insulin Sensitivity in Men With the Metabolic Syndrome

Lidocaine and Ketamine in Abdominal Surgery

Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery

Pain Control in Colorectal Surgery: Liposomal Bupivacaine Block Versus Intravenous Lidociane

Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies

Lidocaine for Diabetic Peripheral Neuropathy

Effects of Intravenous Lidocaine on Endometriosis Pain

Systemic Lidocaine Infusion for Pain Control in Ventral Hernia

Comparison of Continuous Intravenous Lidocaine Infusion Versus ESP Block for Rib Fracture Analgesia

Continuous Intravenous Lidocaine Infusion Versus Placebo for Rib Fracture Analgesia

Cryo Rib Fracture Study

Pilot Study About Safety and Efficacy of Atomized Intrapleural Lidocaine During Pleuroscopy

Intrauterine Lidocaine Infusion for Essure Sterilization Procedures

Tracking Outcomes in Patients With Chronic Pain Prescribed Intravenous Lidocaine

The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers

Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

Depodur vs Fentanyl Infusion for Post-C/S Analgesia

Lidocaine Infusion for Chronic Pain in Opioid Dependent Patients

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty

IV Lidocaine on Postoperative Pain and QOR on Morbid Obese Patients Undergoing Bypass Surgery

VectorFlow Tunneled Dialysis Catheter (TDC) Versus Palindrome TDC