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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional

Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome

NCT00991068
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2012 · Synced Sep 12, 2026, 11:05 AM EDT
Withdrawn Phase 4 Interventional

Adjunctive 5% Lidocaine Patches for Acute Non-radicular Low Back Pain in Emergency Department Patients

NCT03301766
View directory record Official record
Conditions
Low Back Pain
Interventions
lidocaine 5% patch, standard therapy, Non-medicated patch
Drug
Lead sponsor
Cook County Health
Government
Eligibility
24 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 12, 2026, 11:05 AM EDT
Not listed Not applicable Interventional

Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With Hip OA Compared to Intra-articular Steroid Injections

NCT04329884
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
Cooled RFA treatment with COOLIEF* device, intra-articular corticosteroid injection
Procedure · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 3 Interventional

MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder

NCT01161615
View directory record Official record
Conditions
Acute Tendonitis, Bursitis
Interventions
MRX-7EAT, Placebo
Drug
Lead sponsor
MEDRx USA, Inc.
Industry
Eligibility
14 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
35
States / cities
Chandler, Arizona • Phoenix, Arizona • North Little Rock, Arkansas + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Adhesion Performance Study of Lidocaine Topical System 1.8% Compared to Generic Lidocaine Patch 5% in Healthy, Adult, Human Subjects

NCT04319926
View directory record Official record
Conditions
Healthy
Interventions
lidocaine topical system 1.8%, lidocaine patch 5%
Drug
Lead sponsor
Scilex Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Dilworth, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 1 Interventional Results available

A Safety, Tolerability and Preliminary Efficacy Study of LiRIS® 400 mg in Women With Interstitial Cystitis (IC) and Hunner's Lesions

NCT01879683
View directory record Official record
Conditions
Chronic Interstitial Cystitis
Interventions
LiRIS® 400 mg
Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
Daytona Beach, Florida • Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 17, 2015 · Synced Sep 12, 2026, 11:05 AM EDT
Suspended Phase 4 Interventional

Pharmacokinetic Study of Synera™ in Neonates and Infants

NCT00747669
View directory record Official record
Conditions
Pain
Interventions
lidocaine 70mg and tetracaine 70mg topical patch
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
Up to 4 Months
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 22, 2012 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 2 Interventional Results available

The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children

NCT00530803
View directory record Official record
Conditions
Pain, Needle Phobia
Interventions
EMLA Cream, Synera Patch
Drug · Combination Product
Lead sponsor
Montefiore Medical Center
Other
Eligibility
4 Years to 12 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 4 Interventional

Synera™ for Epidural Needle Insertion

NCT00564785
View directory record Official record
Conditions
Pain Associated With Epidural Needle Insertion
Interventions
Synera(TM), Placebo patch
Drug · Other
Lead sponsor
IWK Health Centre
Other
Eligibility
18 Years and older · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 27, 2007 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy

NCT01086150
View directory record Official record
Conditions
Diabetic Peripheral Neuropathy
Interventions
Skin biopsy, Lidocaine 5% patches
Procedure · Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jun 10, 2020 · Synced Sep 12, 2026, 11:05 AM EDT
Active, not recruiting Not applicable Interventional

Trident Multi-tined Cannula for Cervical MBRFA Compared to the Conventional Cannula

NCT05424198
View directory record Official record
Conditions
Cervical Pain, Cervical Facet Joint Pain
Interventions
Cervical Medial Branch Radiofrequency Ablation
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Farmington, Utah • Salt Lake City, Utah • South Jordan, Utah
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 4 Interventional

Lidoderm® (Lidocaine Patch 5%) in Diabetic and Idiopathic Neuropathy

NCT00903851
View directory record Official record
Conditions
Diabetes
Interventions
Lidoderm
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years to 90 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
4
States / cities
Birmingham, Alabama • Hueytown, Alabama • Jacksonville, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2010 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 4 Interventional

Topical Lidocaine Patch in Low Back Pain

NCT00904540
View directory record Official record
Conditions
Acute and Chronic Non-radicular LBP
Interventions
Lidoderm®
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
7
States / cities
Phoenix, Arizona • Mill Valley, California • Weston, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Not applicable Interventional Results available

Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes

NCT02746874
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Radiofrequency Ablation (RFA), Simulated Radiofrequency Ablation (RFA)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
30 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 2 Interventional Results available

Synera Venipuncture Pain

NCT01744197
View directory record Official record
Conditions
Pain, Phlebotomy, Palliative Care
Interventions
Synera (lidocaine 70mg/tetracaine 70mg)
Drug
Lead sponsor
US Oncology Research
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 24, 2018 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 3 Interventional

Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery

NCT00058357
View directory record Official record
Conditions
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
lidocaine, placebo
Drug · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years to 120 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
159
States / cities
Scottsdale, Arizona • Washington D.C., District of Columbia • Jacksonville, Florida + 95 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2016 · Synced Sep 12, 2026, 11:05 AM EDT
Terminated Phase 4 Interventional

Lidocaine Patch 5% Versus Celecoxib 200 mg in Chronic Axial Low Back Pain

NCT00904397
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®, Celecoxib
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
21
States / cities
Northport, Alabama • Phoenix, Arizona • Beverly Hills, California + 18 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2010 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pharmacokinetics of Lidocaine in Healthy Adults

NCT03310970
View directory record Official record
Conditions
Healthy
Interventions
Lidocaine 5% patch, Lidocaine hydrochloride, Lidoderm 5% patch
Drug
Lead sponsor
Nicole K Brogden
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 12, 2026, 11:05 AM EDT
Not listed Phase 4 Interventional

In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?

NCT01576770
View directory record Official record
Conditions
Pain on Propofol IV Injection
Interventions
lidocaine/tetracaine transdermal patch (NDC 43469-864-01), Gebauer's Ethyl Chloride
Device · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
6 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 11, 2012 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetics and Adhesion of Lidocaine Topical System 1.8% With Water Exposure

NCT04784728
View directory record Official record
Conditions
Healthy
Interventions
Lidocaine topical system 1.8%
Drug
Lead sponsor
Scilex Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Dilworth, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 4, 2021 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 2 Interventional

A Study Comparing The Efficacy And Safety Of Lidocaine 5% Patch With Placebo In Patients With Chronic Axial Low Back Pain

NCT00904111
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®, Placebo Topical Patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
18
States / cities
Birmingham, Alabama • Phoenix, Arizona • Carlsbad, California + 15 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2013 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Phase 4 Interventional

A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions

NCT00904202
View directory record Official record
Conditions
Postherpetic Neuralgia, Diabetic Neuropathy, Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, HIV Neuropathy, Idiopathic Sensory Neuropathy, Peripheral Neuropathy
Interventions
Placebo Capsules + Placebo Patch, Placebo capsules + Lidoderm®, Gabapentin + Placebo, Gabapentin + Lidoderm®, Gabapentin 300 mg capsules 1800 mg/day + placebo patch, Gabapentin 1800 mg/day + Lidoderm patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
7
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Sep 12, 2026, 11:05 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy

NCT05200806
View directory record Official record
Conditions
Analgesia, Post-Operative Pain, Breakthrough Pain, Colectomy
Interventions
Non-Narcotic ERAS Post-Operative Pain Management
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Sep 12, 2026, 11:05 AM EDT
Completed Not applicable Interventional Results available

The Effect of Intravenous Lidocaine on Allodynia

NCT00659633
View directory record Official record
Conditions
Pain
Interventions
lidocaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Sep 12, 2026, 11:05 AM EDT