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Showing 1–24 of 40 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Linoleic Acid Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Natural Versus Man-Made Trans Fatty Acids on Lipoprotein Profiles: A Pilot Study

NCT00535886
View directory record Official record
Conditions
Cardiovascular Disease, Diabetes, Dyslipidemia
Interventions
Man-made Trans FA, Natural Trans FA, Oleic Acid
Dietary Supplement
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
18 Years and older · Male only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated May 6, 2008 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Conjugated Linoleic Acid on Body Fat in Overweight Children

NCT00575991
View directory record Official record
Conditions
Overweight
Interventions
Conjugated linoleic acid
Dietary Supplement
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
6 Years to 10 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 12, 2012 · Synced Sep 2, 2026, 5:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sorting of Oral Sensations

NCT02390180
View directory record Official record
Conditions
Taste Qualities, Primary Tastes
Interventions
Tasting solutions
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional

Supplementation With Conjugated Linoleic Acid (CLA) as Complementary Therapy in the Management of Type 2 Diabetes Mellitus (Women's Diabetes Study)

NCT01121471
View directory record Official record
Conditions
Diabetes Mellitus
Interventions
Conjugated Linoleic Acid (CLA), Safflower OIl
Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2010 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional

Healthy Oils for Women (HOW Study)

NCT02063165
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
High Linoleic Safflower Oil
Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
50 Years to 69 Years · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 28, 2024 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Phase 2 Interventional Results available

Fatty Acid Supplementation in Children With ASD (Study 2)

NCT04312932
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
LCPUFA Oil Supplement, Canola Oil Placebo
Drug · Dietary Supplement
Lead sponsor
Sarah Keim
Other
Eligibility
2 Years to 6 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Phase 1Phase 2 Interventional Results available

A First in Human Study of RT001 in Patients With Friedreich's Ataxia

NCT02445794
View directory record Official record
Conditions
Friedreich's Ataxia
Interventions
Low dose cohort, High dose cohort
Drug
Lead sponsor
Biojiva LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Long Beach, California • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 26, 2020 · Synced Sep 2, 2026, 5:46 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional

A Study to Assess Efficacy and Safety of RT001 in Subjects With Infantile Neuroaxonal Dystrophy

NCT03570931
View directory record Official record
Conditions
Infantile Neuroaxonal Dystrophy
Interventions
RT001
Drug
Lead sponsor
Biojiva LLC
Industry
Eligibility
18 Months to 10 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
San Francisco, California • Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Sep 2, 2026, 5:46 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Healthy Cookie Energy Study: Understanding How Healthy Cookies Affect Mitochondrial Biology

NCT04677920
View directory record Official record
Conditions
Healthy Adults
Interventions
High Linoleic Acid Healthy Cookies
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Phase 2 Interventional Results available

Effects of CLA Supplements on Body Weight and Fat Oxidation

NCT00204932
View directory record Official record
Conditions
Obesity
Interventions
conjugated linoleic acid
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 44 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition

NCT01251887
View directory record Official record
Conditions
Weight Gain, Healthy Subjects, Obesity, Women
Interventions
Linoleic Acid, Docosahexaenoic Acid, Eicosapentaenoic Acid
Dietary Supplement
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 50 Years · Female only
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hallelujah Acres Omega 3 Fat Study

NCT01517685
View directory record Official record
Conditions
Omega 3 Fat Status
Interventions
Organic flax seed oil, fish oil
Dietary Supplement
Lead sponsor
Hallelujah Acres
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Zillah, Washington
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Sep 2, 2026, 5:46 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Healthy Cookie Study: Understanding How Healthy Cookies Affect Fat in the Blood,

NCT02841618
View directory record Official record
Conditions
Healthy Adults
Interventions
High Linoleic Acid Healthy Cookies, High Oleic Acid Healthy Cookies
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 80 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparative Split-Face Study of the Effects of a Retinol Alternative Cream on Improving Facial Skin Aging

NCT06125912
View directory record Official record
Conditions
Skin Aging
Interventions
Dime Beauty TBT Cream, Positive Control
Other
Lead sponsor
Dime Beauty Co.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Effects of Fats on Satiety and Energy Needs

NCT02496936
View directory record Official record
Conditions
Obesity
Interventions
SFA, MUFA, PUFA-LA, ALA, LCn3
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

FFA Hypertension and Inflammation in Lean and Obese Subjects

NCT00721617
View directory record Official record
Conditions
Diabetes, Hypertension, Obesity
Interventions
Intralipid 20%, Normal Saline, Oral fat load
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 26, 2015 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Omega 3 Fatty Acid Trial

NCT00586222
View directory record Official record
Conditions
Omega-3 Fatty Acids, Pediatric Bipolar Disorder, Adolescent Bipolar Disorder, Magnetic Resonance Spectroscopy Imaging
Interventions
Omega-3 Fatty Acid, Placebo
Dietary Supplement · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
12 Years to 18 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2012 · Synced Sep 2, 2026, 5:46 PM EDT
Recruiting Not applicable Interventional

The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study

NCT06361511
View directory record Official record
Conditions
Sarcopenia
Interventions
High Linoleic Acid Foods, High Oleic Acid Foods
Other
Lead sponsor
Ohio State University
Other
Eligibility
65 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Conjugated Linoleic Acid Supplement on Body Composition

NCT00347373
View directory record Official record
Conditions
Obesity
Interventions
Tonalin Conjugated linoleic acid (dietary supplement)
Drug
Lead sponsor
University of North Carolina
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 3, 2006 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Trans Fatty Acids From Ruminant Sources on Risk Factors for Cardiovascular Disease

NCT00942656
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
PHVO, CLA, VA, base
Other
Lead sponsor
United States Department of Agriculture (USDA)
Federal
Eligibility
25 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2011 · Synced Sep 2, 2026, 5:46 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Chronic Effects of Fats on Satiety & Energy Needs

NCT03236181
View directory record Official record
Conditions
Overweight, Obesity
Interventions
SFA, MUFA, PUFA, LCn3
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
20 Years to 55 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Aug 2, 2018 · Synced Sep 2, 2026, 5:46 PM EDT
Terminated Phase 1 Interventional

A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors

NCT00951158
View directory record Official record
Conditions
Advanced Solid Tumors
Interventions
Conjugated Linoleic Acid, Conjugated Linoleic Acid
Dietary Supplement · Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Role of Polyunsaturated Fatty Acids (PUFA)-Gene Interactions in Heath Disparities

NCT02962128
View directory record Official record
Conditions
Fatty Acid-Gene Interactions
Interventions
High Linoleic Acid (LA) Diet, Low Linoleic Acid (LA) Diet
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 30, 2022 · Synced Sep 2, 2026, 5:46 PM EDT
Completed Phase 3 Interventional Results available

A Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects With Friedreich's Ataxia

NCT04102501
View directory record Official record
Conditions
Friedreich's Ataxia
Interventions
RT001, Placebo
Drug
Lead sponsor
Biojiva LLC
Industry
Eligibility
12 Years to 50 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
6
States / cities
Long Beach, California • Los Angeles, California • Gainesville, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Sep 2, 2026, 5:46 PM EDT