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Conditions: Alzheimer's Disease
Interventions: Liposuction under local anesthesia, Infusion of AD-SVF via IV and Intranasal; Procedure · Biological
Lead sponsor: Ageless Regenerative Institute; Industry
Eligibility: 55 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Aventura, Florida

Conditions: Continuous Femoral Nerve Blocks in Healthy Volunteers
Interventions: Catheter Anterior to the Femoral Nerve, Catheter Posterior to the Femoral Nerve; Procedure
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: San Diego, California

Conditions: Osteoarthritis
Interventions: Synvisc (Hylan G-F20; hyaluronan injection), Bupivicaine (local anesthesia injection), Kenalog (triamcinolone; corticosteroid injection); Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 45 Years to 95 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Pleural Effusion, Cancer
Interventions: Pleuroscopy first, Thoracentesis first; Procedure
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: New York, New York

Conditions: Kidney Stone, Surgery
Interventions: 4mg PF Dexamethasone, Control Test; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Blepharoptosis
Interventions: Frontal nerve block with 2% lidocaine with 1:100,000 dilution of epinephrine, Subconjunctival injection of 2% lidocaine with 1:100,000 dilution with epinephrine; Procedure
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 100 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Safety of Neosaxitoxin in Healthy Volunteers
Interventions: Neosaxitoxin in saline, NeoSTX + bupivacaine 0.2%, NeoSTX + bupivacaine 0.2% + epinephrine 5mcg/ml, Saline placebo; Drug · Other
Lead sponsor: Charles Berde; Other
Eligibility: 18 Years to 35 Years · Male only
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions: Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline; Drug
Lead sponsor: John O'Toole; Other
Eligibility: 18 Years to 80 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Benign Prostatic Hyperplasia
Interventions: UroLift® System; Device
Lead sponsor: NeoTract, Inc.; Industry
Eligibility: 50 Years and older · Male only
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 7
States / cities: San Diego, California • Daytona Beach, Florida • St. Petersburg, Florida + 4 more

Conditions: Twin to Twin Transfusion Syndrome
Interventions: S-LPC:Selective Laser Photocoagulation; Device
Lead sponsor: University of Tennessee; Other
Eligibility: 16 Weeks to 27 Weeks · Female only
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2020
U.S. locations: 2
States / cities: Memphis, Tennessee

Conditions: Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions: Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA); Procedure · Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Surgery, Pneumonia, Surgical Site Infection
Interventions: Continuous Sternal Block, Opioid based analgesia; Device · Drug
Lead sponsor: Halyard Health; Industry
Eligibility: 18 Years and older
Enrollment: 647 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 8
States / cities: Birmingham, Alabama • Newark, Delaware • Lexington, Kentucky + 5 more

Conditions: Breast Cancer, Healthy, no Evidence of Disease
Interventions: Random fine need aspiration (rFNA), Mammogram; Procedure · Other
Lead sponsor: Northwestern University; Other
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 385 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Inguinal Hernia
Interventions: Regional Anesthesia, General Anesthesia; Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: Up to 60 Weeks
Enrollment: 643 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2018
U.S. locations: 10
States / cities: Aurora, Colorado • Chicago, Illinois • Iowa City, Iowa + 7 more

Conditions: Anesthesia, Local, Phrenic Nerve Paralysis, Upper Extremity Injury, Shoulder Injury
Interventions: Interscalene brachial plexus nerve block, Erector spinae plane block; Procedure
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Otolaryngologic Surgery
Interventions: ropivacaine, Saline; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 3 Months to 18 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Liver Disease, Pain
Interventions: paravertebral blocks; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pain, Fracture
Interventions: Ankle SSB, Ankle OnQ, DR SSB, DR OnQ; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: PTSD, Cardiac Arrest, Anxiety and Fear, Sleep Disturbance, Health Behavior
Interventions: stellate ganglion block injection, Normal saline injection, Psychoeducation; Procedure · Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Inguinal Hernia
Interventions: TLC590, Naropin; Drug
Lead sponsor: Taiwan Liposome Company; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Draper, Utah

Conditions: Pain, Osteoarthritis
Interventions: Canal Block and Capsular Injection, Femoral Nerve Block with Tibial Nerve Block; Procedure
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 80 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Pain, Acute Postoperative, Trauma Injury
Interventions: Continuous Infusion of ropivacaine 0.2%, Titratable Automated Intermittent Boluses of ropivacaine 0.2%; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: San Diego, California

Conditions: Obstructive Sleep Apnea (OSA)
Interventions: Pillar Palatal Implant System, Sham system; Device
Lead sponsor: Medtronic Xomed, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 7
States / cities: Little Rock, Arkansas • Berkeley, California • Denver, Colorado + 4 more

Conditions: Return of Motor and Sensory Blockade, Anesthesia, Spinal, Decrease Discharge Time Status Post Hemorrhoidectomy
Interventions: 1% chloroprocaine, 0.75% bupivacaine; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: The Bronx, New York

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Study to Assess the Safety and Effects of Autologous Adipose-Derived Stromal Cells in Patients With Alzheimer's Disease

Effects of Catheter Tip Location Relative to the Femoral Nerve on Sensory and Motor Function

A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb

Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions

Regional Erector Spinae Analgesic Block vs Standard of Care Undergoing Percutaneous Nephrolithotomy

Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid

Safety Study of Long-Acting Local Anesthetic

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

UroLift System TOlerability and ReCovery When Administering Local Anesthesia

Laser Photocoagulation in Twin to Twin Transfusion Syndrome

Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery

Multicenter Infection Surveillance Study Following Open Heart Surgery

Study of Breast Tissue in Women Not Previously Diagnosed With Breast Cancer Who Are Undergoing Fine Needle Aspiration

A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants

Erector Spinae Plane Versus Interscalene Blocks for Shoulder Surgery

Superficial Cervical Plexus Block for Improved Outcomes in Pediatric Otolaryngologic Surgery

Comparison Between Epidural and Bilateral Paravertebral Blocks in Liver Resection

Single Shot Versus OnQ Pump in Extremity Fractures

Stellate Ganglion Blockade to Reduce Cardiac Anxiety and PTSD Symptoms in Cardiac Arrest Survivors

Phase I/II Dose-escalation Study to Evaluate Safety, PK and Efficacy of TLC590 for Postsurgical Pain Management

Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty

Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia

Palatal Implants in Combination With Continuous Positive Airway Pressure to Treat Obstructive Sleep Apnea

1% Chloroprocaine(PF) vs. Bupivacaine Spinals