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ClinicalTrials.gov public records Last synced Oct 1, 2026, 2:16 PM EDT

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Showing 25–48 of 89 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Local infiltration with local anesthetic Clear all
Completed Phase 4 Interventional Results available

Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery

NCT05720949
View directory record Official record
Conditions
ACL, Anterior Cruciate Ligament Injuries
Interventions
Genicular Nerve Block with bupivacaine and preservative free dexamethasone
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty

NCT02876055
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Not applicable Interventional Results available

Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery

NCT01693900
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Pre-operative Ultrasound FICB Group, Intra-operative FICB Group
Procedure
Lead sponsor
Randy Fayne, DO
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 15, 2018 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Not applicable Interventional

Comparison of Two Different Pain Management Techniques in Pediatric Patients Undergoing a Hernia Repair

NCT01740193
View directory record Official record
Conditions
Pain, Inguinal Hernia
Interventions
TAP Block, Ilioinguinal/iliohypogastric blockade
Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 10 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery

NCT03196505
View directory record Official record
Conditions
Bariatric Surgery Candidate, Pain, Postoperative
Interventions
Exparel 266 MG Per 20 ML Injection, Bupivacaine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2020 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Results available

Dose-Response Relationships for Hemidiaphragmatic Paresis Following Ultrasound-Guided Supraclavicular Block

NCT03138577
View directory record Official record
Conditions
Surgery of Right Upper Extremity
Interventions
Ultrasound Imaging, Supraclavicular Block, Bedside Negative Inspiratory Force Meter
Diagnostic Test · Drug · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 105 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 13, 2020 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Serratus Anterior Plane Block Combined With Transversus Thoracic Muscle Plane Block Versus Conventional Local Anesthetic Infiltration for SICD Implantation: A Randomized Controlled Trial

NCT05092490
View directory record Official record
Conditions
Serratus Anterior Plane Block, Transversus Thoracis Plane Block, Subcutaneous ICD
Interventions
Combined serratus anterior plane block and transversus thoracis plane block, Standard local infiltration technique
Procedure
Lead sponsor
New York Presbyterian Brooklyn Methodist Hospital
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Nov 14, 2023 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Results available

TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy

NCT02519023
View directory record Official record
Conditions
Acute Pain
Interventions
Liposomal Bupivacaine, Bupivacaine, Ultrasound, Epinephrine, acetaminophen, ibuprofen, Oxycodone
Drug · Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 8, 2019 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized Control Trial Testing Connective Tissue Grafts vs. Allograft on Dental Implants

NCT01934530
View directory record Official record
Conditions
Dental Implant Soft Tissue Defects in the Anterior Maxilla
Interventions
Soft Tissue Grafting
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Results available

Pectoralis and Serratus Muscle Blocks

NCT03743194
View directory record Official record
Conditions
Post Operative Pain Control
Interventions
Exparel 266 MG Per 20 ML Injection, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Not applicable Interventional

Laser Photocoagulation in Twin to Twin Transfusion Syndrome

NCT02506049
View directory record Official record
Conditions
Twin to Twin Transfusion Syndrome
Interventions
S-LPC:Selective Laser Photocoagulation
Device
Lead sponsor
University of Tennessee
Other
Eligibility
16 Weeks to 27 Weeks · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
2
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Not applicable Interventional Results available

Study of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Surgery

NCT01698268
View directory record Official record
Conditions
Hydrocele, Inguinal Hernia
Interventions
TAP block, Local Infiltration
Procedure
Lead sponsor
Kaveh Aslani, MD
Other
Eligibility
2 Years to 8 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Randomized Trial of Wound Infiltration With Extended-release Bupivacaine Before Laparoscopic or Robotic Hysterectomy

NCT02352922
View directory record Official record
Conditions
Pain, Postoperative, Surgical Procedure, Unspecified
Interventions
Liposomal Bupivacaine, Bupivacaine HCl
Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years and older · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 1, 2020 · Synced Oct 1, 2026, 2:16 PM EDT
Terminated Not applicable Interventional Results available

Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy

NCT02164929
View directory record Official record
Conditions
Laparoscopic Colorectal Resection
Interventions
TAP block, Epidural, Paravertebral block, Acetaminophen 1g IV, Dexamethasone 4mg, Midazolam up to 2mg, Propofol 1-2.5 mg/kg, Sevoflurane to keep a bispectral index of between 40-60, Local infiltration with 10 mL of plain ropivacaine 0.25%, Lidocaine, Epinephrine, Hydromorphone
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar

NCT01567839
View directory record Official record
Conditions
Anesthetic Effectiveness
Interventions
Mandibular buccal Infiltration injection
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 1, 2014 · Synced Oct 1, 2026, 2:16 PM EDT
Terminated Phase 2 Interventional Results available

Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies

NCT01575028
View directory record Official record
Conditions
Appendicitis
Interventions
Ropivacaine, Bupivacaine
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2015 · Synced Oct 1, 2026, 2:16 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Study of Breast Tissue in Women Not Previously Diagnosed With Breast Cancer Who Are Undergoing Fine Needle Aspiration

NCT00896636
View directory record Official record
Conditions
Breast Cancer, Healthy, no Evidence of Disease
Interventions
Random fine need aspiration (rFNA), Mammogram
Procedure · Other
Lead sponsor
Northwestern University
Other
Eligibility
35 Years to 60 Years · Female only
Enrollment
385 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Oct 1, 2026, 2:16 PM EDT
Completed No phase listed Observational

Comparison of Epidural and TAP Block in Abdominal Surgery

NCT01848951
View directory record Official record
Conditions
Acute Pain, Surgery, Regional Anesthesia
Interventions
Epidural, TAP Block
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 1, 2026, 2:16 PM EDT
Terminated Not applicable Interventional

Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)

NCT01668953
View directory record Official record
Conditions
Lateral Epicondylitis (Tennis Elbow)
Interventions
Platelet Rich Plasma (PRP) Injection, Whole Blood Injection, Dry Needle Fenestration, Sham Injection
Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 10, 2023 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 1 Interventional Results available

Injection of Local Anesthetic to Trocar Insertion Sites After Laparoscopy

NCT01688596
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 2 Interventional Results available

Paclitaxel, Cyclophosphamide & Doxorubicin, Autologous Dendritic Cells & Surgery in Stage II/III Breast Cancer (Women)

NCT00499083
View directory record Official record
Conditions
Breast Cancer
Interventions
therapeutic autologous dendritic cells, aromatase inhibition therapy, cyclophosphamide, doxorubicin hydrochloride, paclitaxel, tamoxifen citrate, gene expression analysis, protein expression analysis, reverse transcriptase-polymerase chain reaction, immunoenzyme technique, immunohistochemistry staining method, laboratory biomarker analysis, adjuvant therapy, biopsy, conventional surgery, neoadjuvant therapy, radiation therapy
Biological · Drug · Genetic + 3 more
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 120 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
2
States / cities
Tampa, Florida • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 29, 2023 · Synced Oct 1, 2026, 2:16 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Comparison of Articaine Mandibular Infiltration to Lidocaine Inferior Alveolar Nerve Block in Pediatric Patients

NCT04865848
View directory record Official record
Conditions
Anesthesia
Interventions
Dental local anesthesia
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
4 Years to 10 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Oct 1, 2026, 2:16 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy

NCT04996251
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine Injection
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Oct 1, 2026, 2:16 PM EDT
Completed No phase listed Observational

Medical Review: Hand Surgery After Local Block Versus Non-block

NCT01110759
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2013 · Synced Oct 1, 2026, 2:16 PM EDT