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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Lotrafilcon B Clear all
Completed Not applicable Interventional Results available

Clinical Assessment of a HYDRAGLYDE® Regimen

NCT03026257
View directory record Official record
Conditions
Refractive Errors, Myopia, Hypermetropia
Interventions
Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent, Hydrogen peroxide-based contact lens solution with added wetting agent, Senofilcon C contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses, Habitual Multi-Purpose Solution (HMPS)
Device
Lead sponsor
Alcon, a Novartis Company
Industry
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Birmingham, Alabama • Cleveland, Ohio • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Central Corneal Swelling With Silicone Hydrogel Materials

NCT02328937
View directory record Official record
Conditions
Corneal Swelling
Interventions
etafilcon A, lotrafilcon B, comfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Manufacturing Process for a Frequent Replacement Silicone Hydrogel Multifocal Contact Lens

NCT05765227
View directory record Official record
Conditions
Refractive Ametropia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, Hydrogen peroxide-based cleaning and disinfection system
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

On-Eye Optical Quality of Lotrafilcon B Lenses Over 12 Hours

NCT03881670
View directory record Official record
Conditions
Hyperopia, Myopia
Interventions
Lotrafilcon B, lotrafilcon B with Hydraluxe
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 4, 2026, 5:58 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Lotrafilcon B Plano Cosmetic Contact Lenses Study

NCT06493383
View directory record Official record
Conditions
Cosmetic Appearance
Interventions
Lotrafilcon B plano cosmetic contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
12 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Dispensing Evaluation of a Prototype Contact Lens and a Marketed Contact Lens

NCT01094743
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A prototype lens, lotrafilcon B lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
2
States / cities
Jacksonville, Florida • Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Performance of Investigational Contact Lenses in a Presbyopic Population

NCT01763047
View directory record Official record
Conditions
Presbyopia
Interventions
etafilcon A, lotrafilcon B
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
298 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
19
States / cities
Mission Viejo, California • Jacksonville, Florida • Saint Augustine, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study of Approved and Investigational Contact Lenses

NCT02708524
View directory record Official record
Conditions
Visual Acuity
Interventions
Senofilcon C Contact Lens, Comfilcon A Contact Lens, Lotrafilcon B Contact Lens, Samfilcon A Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
554 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
18
States / cities
Montgomery, Alabama • Fruit Cove, Florida • Jacksonville, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Sep 4, 2026, 5:58 AM EDT
Completed No phase listed Observational

Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses

NCT05886894
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B multifocal soft contact lenses, Comfilcon A multifocal soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
8
States / cities
San Diego, California • Jacksonville, Florida • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Performance Evaluation of Reusable Contact Lenses When Worn For One Month By Habitual Soft Contact Lens Wearers

NCT06098339
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
Lens A (fanfilcon A), Lens B (lotrafilcon B)
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Ocoee, Florida • State College, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Sep 4, 2026, 5:58 AM EDT
Completed No phase listed Observational

Air Optix Extended Wear Contact Lenses

NCT05886881
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive, Comfilcon A spherical soft contact lenses, Comfilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Orlando, Florida • Medina, Minnesota • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of an Investigational Multifocal Lens

NCT02223754
View directory record Official record
Conditions
Presbyopia
Interventions
lotrafilcon B, etafilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
371 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
20
States / cities
Montgomery, Alabama • Mission Viejo, California • Jacksonville, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

A Multi-Center Study Comparing the Clinical Performance of Two Silicone Hydrogel Lenses Over 1 Month of Daily Wear

NCT01952665
View directory record Official record
Conditions
Myopia
Interventions
comfilcon A, lotrafilcon B
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
6
States / cities
Campbell, California • Whittier, California • Athens, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2017 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Multi-Center 2-Week Clinical Evaluation of Three Silicone Hydrogel Contact Lenses

NCT01244516
View directory record Official record
Conditions
Myopia
Interventions
galyfilcon A, BC 8.30, lotrafilcon B, BC 8.60, comfilcon A, BC 8.60
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
35
States / cities
Brea, California • Campbell, California • Cupertino, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

NCT05338333
View directory record Official record
Conditions
Presbyopia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, CLEAR CARE®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
8
States / cities
Maitland, Florida • Orlando, Florida • Pittsburg, Kansas + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 4, 2026, 5:58 AM EDT
Completed No phase listed Observational

Air Optix Daily Wear Contact Lenses

NCT05827224
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive, Comfilcon A spherical soft contact lenses, Comfilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Timeline
2023 – 2024
U.S. locations
5
States / cities
Orlando, Florida • Medina, Minnesota • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Assessing Fitting Guides in Alcon Multifocal Contact Lenses

NCT03118934
View directory record Official record
Conditions
Presbyopia, Refractive Errors
Interventions
Lotrafilcon B multifocal contact lenses, Nelfilcon A multifocal contact lenses, Delefilcon A multifocal contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years to 65 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
14
States / cities
Phoenix, Arizona • San Diego, California • Pensacola, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance Comparison of Two Contact Lenses

NCT00975585
View directory record Official record
Conditions
Myopia
Interventions
senofilcon A, lotrafilcon B
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 45 Years
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
25
States / cities
North Little Rock, Arkansas • Campbell, California • Colorado Springs, Colorado + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation Of Two Daily Disposable Contact Lenses And A Monthly Replacement Lens

NCT01151371
View directory record Official record
Conditions
Myopia
Interventions
narafilcon B contact lens, nelfilcon A contact lens, lotrafilcon B contact lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
452 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
28
States / cities
Brea, California • Canoga Park, California • Corona, California + 23 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Comparison of Two Silicone Hydrogel Toric Contact Lenses

NCT03392532
View directory record Official record
Conditions
Astigmatism
Interventions
Lotrafilcon B toric contact lenses with HYDRAGLYDE, Lotrafilcon B toric contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 28, 2019 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems

NCT01699750
View directory record Official record
Conditions
Myopia, Astigmatism, Refractive Error
Interventions
Lotrafilcon B contact lenses, Senofilcon A contact lenses, OPTI-FREE® PUREMOIST® MPDS, BIOTRUE®, Balafilcon A contact lenses, ReNu® Multiplus®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2014 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Proclear 1-D Multifocal Nondispensing Study

NCT01526902
View directory record Official record
Conditions
Presbyopia
Interventions
omafilcon A / PC 1-D MF, lotrafilcon B / Air Optix MF
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
40 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 6, 2014 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

NCT05702541
View directory record Official record
Conditions
Presbyopia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, Hydrogen peroxide-based cleaning and disinfection system
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2024 · Synced Sep 4, 2026, 5:58 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of an Investigational Soft Contact Lens

NCT01254747
View directory record Official record
Conditions
Myopia
Interventions
Delefilcon A contact lens, Lotrafilcon B contact lens (O2 OPTIX, AIR OPTIX), Nelfilcon A contact lens (DAILIES AquaComfort Plus), Narafilcon A contact lens (1-DAY ACUVUE TRUEYE)
Device
Lead sponsor
CIBA VISION
Industry
Eligibility
Not listed
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Duluth, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 9, 2012 · Synced Sep 4, 2026, 5:58 AM EDT