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Showing 1–24 of 328 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Low Energy Diet Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

The Safety and Effectiveness of Low and High Carbohydrate Diets

NCT00079547
View directory record Official record
Conditions
Obesity
Interventions
Low-calorie diet, low-carbohydrate diet
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
3
States / cities
Denver, Colorado • St Louis, Missouri • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2013 · Synced Sep 12, 2026, 9:31 PM EDT
Terminated Not applicable Interventional Results available

Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation

NCT03607500
View directory record Official record
Conditions
Kidney Transplant; Complications, Glomerular Disease, Weight Gain, Kidney Transplant
Interventions
caloric intake reduction
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 12, 2026, 9:31 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Incorporating Lean Beef Into a Protein-rich Diet During Resistance Training on Muscle and Tendon Strength in Older Women

NCT04347447
View directory record Official record
Conditions
Sarcopenia, Aging
Interventions
Exercise training
Other
Lead sponsor
Purdue University
Other
Eligibility
60 Years to 80 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 28, 2023 · Synced Sep 12, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

NCT04959474
View directory record Official record
Conditions
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage 1 Breast Cancer AJCC v8, Anatomic Stage 2 Breast Cancer AJCC v8, Anatomic Stage 3 Breast Cancer AJCC v8, Breast Ductal Carcinoma in Situ, Invasive Breast Carcinoma, Triple Negative Breast Carcinoma
Interventions
Best Practice, Stereotactic Body Radiation Therapy, Resection, Sentinel Lymph Node Biopsy, Dietary Intervention, Questionnaire Administration, Quality-of-Life Assessment, Mammography, Biospecimen Collection
Other · Radiation · Procedure
Lead sponsor
Thomas Jefferson University
Other
Eligibility
40 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults

NCT02251574
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Low Calorie Diet, Very Low Calorie Diet, Standard Care
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Ketogenic Diet to Improve Neuro-recovery

NCT03509571
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Ketogenic Diet, Standard Diet
Other
Lead sponsor
Ohio State University
Other
Eligibility
19 Years to 60 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)

NCT00151411
View directory record Official record
Conditions
Polycystic Ovary Syndrome
Interventions
Metformin, Placebo, Lifestyle Intervention
Drug · Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
12 Years to 39 Years · Female only
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional

The Healthy Eating Choices for Life Program

NCT01096719
View directory record Official record
Conditions
Obesity
Interventions
Standard Behavioral Weight Loss Intervention, Dietary Goal: Reduction in Energy Density of Dietary Intake, Dietary Goal: Reduction of Energy Intake
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 12, 2026, 9:31 PM EDT
Withdrawn Not applicable Interventional

Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease

NCT05457881
View directory record Official record
Conditions
Vascular Diseases, Surgery
Interventions
Scandi-Shake
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 12, 2026, 9:31 PM EDT
Completed No phase listed Observational

Psychological Effects of Bone Marrow Transplants in Children

NCT00645931
View directory record Official record
Conditions
Psychological
Interventions
protein and calorie controlled diet and self-hypnotic relaxation
Behavioral
Lead sponsor
Corewell Health West
Other
Eligibility
1 Day to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2023 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mediterranean Style Diet and Low Glycemic Responses

NCT03410719
View directory record Official record
Conditions
Insulin Sensitivity
Interventions
Hi GI
Other
Lead sponsor
Purdue University
Other
Eligibility
30 Years to 69 Years
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bitter Taste and Weight Loss in Women

NCT01856660
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Low-Carbohydrate Diet, Low-fat Diet
Behavioral
Lead sponsor
Rutgers University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 23, 2021 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impacts of Wild Blueberries on Appetite and Weight Regulation

NCT05736432
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Blueberries, Placebo
Dietary Supplement
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cerebrospinal Fluid Biomarkers in Bariatric Surgery

NCT04350892
View directory record Official record
Conditions
Obesity
Interventions
Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Very Low Calorie Diet (VLCD)
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Brain Energy for Amyloid Transformation in Alzheimer's Disease Study

NCT03472664
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment
Interventions
low carbohydrate/high fat diet, low fat/high carbohydrate diet
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
55 Years to 85 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional

The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

NCT06106035
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
Interventions
low-fat vegan diet
Behavioral
Lead sponsor
Physicians Committee for Responsible Medicine
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Phase 2 Interventional

Reducing Weight and Diabetes Risk in an Underserved Population (STRIDE)

NCT00790517
View directory record Official record
Conditions
Weight Loss, Diabetes Mellitus, Type 2, Psychotic Disorders
Interventions
Premier Lifestyle Intervention with DASH Diet
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
3
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Calorie Restriction in Multiple Sclerosis Patients

NCT02411838
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Calorie restriction
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 28, 2020 · Synced Sep 12, 2026, 9:31 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Low-calorie Diet in Isolated Impaired Fasting Glucose

NCT06451055
View directory record Official record
Conditions
Isolated Impaired Fasting Glucose
Interventions
Low-calorie diet, Routine dietary and physical activity habits
Behavioral
Lead sponsor
Emory University
Other
Eligibility
35 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Phase 2 Interventional

Survival TRaining for ENhancing Total Health (STRENGTH)

NCT00068458
View directory record Official record
Conditions
Breast Cancer, Depression, Weight Changes
Interventions
Calcium-Rich Diet, Arm 2: Exercise + Calcium-Rich Diet, Exercise + Fruit & Vegetable, Low Fat + Calcium Diet
Dietary Supplement · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
4
States / cities
Durham, North Carolina • Goldsboro, North Carolina • Winston-Salem, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Portion Size and Energy Density of a Single Meal in Preschool Children

NCT02299531
View directory record Official record
Conditions
Feeding Behaviors
Interventions
Varying meal energy density and portion size
Other
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 6 Years
Enrollment
131 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2014 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection

NCT00960505
View directory record Official record
Conditions
Coronary Heart Disease, Obesity, Weight Loss
Interventions
Alternate day fasting, Calorie restriction, Control diet
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 20, 2020 · Synced Sep 12, 2026, 9:31 PM EDT
Completed Not applicable Interventional

A Pilot Study to Determine the Efficacy of a Low Carbohydrate Diet in Treatment of Adolescents With Metabolic Syndrome

NCT00940966
View directory record Official record
Conditions
Elevated Triglycerides, Systolic Hypertension, Insulin Resistance, Abdominal Obesity
Interventions
standard ADA diet, energy restricted very-low carbohydrate diet, low glycemic diet
Dietary Supplement
Lead sponsor
CAMC Health System
Other
Eligibility
12 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 12, 2026, 9:31 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional

The Medically Reproducing Bariatric Surgery (MRB) II Study

NCT06363747
View directory record Official record
Conditions
Type 2 Diabetes, Obesity
Interventions
Very Low Calorie Diet
Other
Lead sponsor
Durham VA Medical Center
Federal
Eligibility
25 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 12, 2026, 9:31 PM EDT