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ClinicalTrials.gov public records Last synced Oct 17, 2026, 4:49 AM EDT

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Showing 1–24 of 108 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Low Intensity Focused Ultrasound Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

NCT05697172
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Oct 17, 2026, 4:49 AM EDT
Not yet recruiting Not applicable Interventional

Focused Ultrasound for Behavioral Health

NCT07851038
View directory record Official record
Conditions
Depression, Anxiety, Obsessive Compulsive Disorder (OCD)
Interventions
ATTN201 head-worn focused ultrasound
Device
Lead sponsor
Attune Neurosciences Inc
Industry
Eligibility
22 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

tFUS Imaging & LIFU

NCT07222865
View directory record Official record
Conditions
Brain Imaging
Interventions
Feasibility of imaging using tFUS
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 17, 2026, 4:49 AM EDT
Active, not recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Binge Eating Disorder

NCT06485687
View directory record Official record
Conditions
Binge-Eating Disorder
Interventions
LIFU Neuromodulation
Device
Lead sponsor
Ali Rezai
Other
Eligibility
22 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional

Ultrasound Stimulation for Patients in a Disorder of Consciousness

NCT06939348
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 79 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Pomona, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Completed Not applicable Interventional Results available

LIFUP for Treatment of Motor Deficits in Parkinson's Disease

NCT04593875
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active LIFUP Treatment, Sham LIFUP Treatment
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 85 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Proof-of-Concept Study Evaluating LINFU™

NCT05161013
View directory record Official record
Conditions
Pancreas Adenocarcinoma, Dysplasia
Interventions
LINFU™
Diagnostic Test
Lead sponsor
Adenocyte, LLC
Industry
Eligibility
18 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

NCT07166289
View directory record Official record
Conditions
Treatment-Resistant Depression
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Personalized Ultrasonic Brain Stimulation for Depression (R61)

NCT06902298
View directory record Official record
Conditions
Major Depressive Episode, Depression - Major Depressive Disorder, Treatment-Resistant Major Depressive Disorder
Interventions
LTFUS to SCC, LTFUS to ALIC
Device
Lead sponsor
Brian Mickey
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional

Modulating Escape Using Focused Ultrasound

NCT06273904
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Active transcranial focused ultrasound (tFUS), Sham transcranial focused ultrasound (tFUS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 17, 2026, 4:49 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Study of Low-intensity Focused Ultrasound Effects on Human Memory

NCT06628193
View directory record Official record
Conditions
Memory
Interventions
Low intensity focused ultrasound, Sham (No Treatment)
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Not yet recruiting Not applicable Interventional

LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI)

NCT07710989
View directory record Official record
Conditions
Schizophrenia, Auditory Hallucinations
Interventions
LIFU
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

NCT07221539
View directory record Official record
Conditions
Mental Function
Interventions
Propofol for fMRI, Dexmedetomidine for fMRI, Dorsolateral prefrontal cortex (DLPFC) pulsation, Anterior insular cortex (AIC) pulsation, Central thalamus (CT) pulsation
Procedure · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Completed Not applicable Interventional

The Use of LIFUP in Chronic Disorders of Consciousness

NCT04921683
View directory record Official record
Conditions
Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus, Minimally Conscious State Minus, Traumatic Brain Injury, CVA (Cerebrovascular Accident), Anoxia, Brain, Thalamic Infarction, Coma; Prolonged
Interventions
BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
Device
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated May 6, 2023 · Synced Oct 17, 2026, 4:49 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Investigating Near-Threshold Perception During Ultrasonic Deep Brain Stimulation

NCT07840521
View directory record Official record
Conditions
Consciousness, Level Altered
Interventions
Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy, Multi-modal glymphatic function MRI
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2032
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Not yet recruiting Not applicable Interventional

LIFU for Chronic Pain and Generalized Anxiety Disorder

NCT07686354
View directory record Official record
Conditions
Chronic Pain, Generalized Anxiety Disorder
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Completed Not applicable Interventional Results available

Targeted Adherence Intervention to Reach Glycemic Control With Insulin Therapy for Patients With Diabetes

NCT02846779
View directory record Official record
Conditions
Diabetes
Interventions
Low intensity, Moderate intensity, High intensity
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Oct 17, 2026, 4:49 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Ultrasonic Treatment of Food Addiction

NCT06249711
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Active stimulation with Diadem ultrasonic transducer array, Sham stimulation with Diadem ultrasonic transducer array
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 17, 2026, 4:49 AM EDT
Not listed Phase 2Phase 3 Interventional

Ablatherm Integrated Imaging High Intensity Focused Ultrasound for the Indication of Low Risk, Localized Prostate Cancer

NCT00295802
View directory record Official record
Conditions
Prostate Cancer
Interventions
Integrated Imaging High Intensity Focused Ultrasound, Endocare CRYOcare Cryosurgical and Galil Medical CRYO-HIT Systems (cryotherapy)
Device
Lead sponsor
EDAP TMS S.A.
Industry
Eligibility
50 Years and older · Male only
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
14
States / cities
Arcadia, California • Aurora, Colorado • Ocala, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2014 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound and the Complex Patient

NCT06297200
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain, Anxiety Disorder
Interventions
Low-Intensity Focused Ultrasound, Low-Intensity Focused Ultrasound - sham
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 17, 2026, 4:49 AM EDT
Completed Not applicable Interventional

Sham-Controlled Prospective Study Characterizing Erectile Tissue Ultrasound Changes Resulting From Penile LiSWT

NCT06600893
View directory record Official record
Conditions
Erectile Dysfunctions
Interventions
Low intensity shockwave therapy (LiSWT), Sham
Device
Lead sponsor
San Diego Sexual Medicine
Other
Eligibility
21 Years to 80 Years · Male only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Phase 2 Interventional

Focused Ultrasound for PTSD in Veterans

NCT06820138
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Brainsonix Ultrasound Device
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional

Promoting Recovery After Brain Injury Using Focused Ultrasound

NCT07277309
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
Low-intensity focused ultrasound
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 17, 2026, 4:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound

NCT03192436
View directory record Official record
Conditions
Healthy
Interventions
Ultrasound
Device
Lead sponsor
Carnegie Mellon University
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 17, 2026, 4:49 AM EDT