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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Low Sodium Diet Clear all
Not listed Not applicable Interventional

Effect of DASH on HF Outcomes Heart Failure Status in Older Adults (DASH HF)

NCT06296862
View directory record Official record
Conditions
Heart Failure
Interventions
Dietary Approaches to Stop Hypertension Diet
Other
Lead sponsor
University of Georgia
Other
Eligibility
65 Years to 110 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 29, 2026, 2:11 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Genetic Architecture of Natriuretic Peptides and Blood Pressure Response

NCT07118592
View directory record Official record
Conditions
Hypertension (HTN), Cardiometabolic Diseases
Interventions
Low Salt Diet, High Salt Diet, Saline Infusion
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gut Microbiome, Metabolome, and SSBP

NCT07790900
View directory record Official record
Conditions
Salt-sensitivity of Blood Pressure
Interventions
Dietary sodium
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women

NCT04266704
View directory record Official record
Conditions
Hypertension
Interventions
Sharing Intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Dietary Sodium Intake on Vascular Endothelium

NCT01550315
View directory record Official record
Conditions
Postural Tachycardia Syndrome (POTS)
Interventions
Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
Procedure · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CARDIA-Salt Sensitivity of Blood Pressure (SSBP)

NCT04258332
View directory record Official record
Conditions
Salt Sensitivity of Blood Pressure, Hypertension
Interventions
High Salt Diet, Low Salt Diet
Dietary Supplement
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years to 70 Years
Enrollment
281 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional

Smartstep Smartphone PAD

NCT03479255
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Smartphone-enabled structured exercise therapy (SE-SET), Standard exercise therapy
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 89 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adverse Neurogenic Actions of Dietary Salt

NCT02881515
View directory record Official record
Conditions
Blood Pressure
Interventions
Low Sodium Diet, Medium Sodium Diet, High Sodium Diet
Other
Lead sponsor
University of Delaware
Other
Eligibility
21 Years to 75 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 29, 2026, 2:11 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Dietary Oxalate and Immune Cell Function

NCT03877276
View directory record Official record
Conditions
Kidney Stone
Interventions
Breakfast, Spinach smoothie, Kale smoothie, Blended smoothie, V spinach smoothie, Sodium oxalate drink
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional

Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents

NCT05268042
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease, Obesity
Interventions
Moderately carbohydrate-restricted diet, Fat-restricted diet
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Prospective Phenotyping of Autonomous Aldosterone Secretion

NCT03484130
View directory record Official record
Conditions
Aldosterone Disorder, Adrenal Gland Disease, Blood Pressure
Interventions
Sodium loaded diet, Restricted sodium diet
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
35 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Diet as a Potential Treatment for Autosomal Dominant Polycystic Kidney Disease

NCT02225860
View directory record Official record
Conditions
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions
Diet and water adjustment
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Acute Dietary Sodium on Cerebrovascular Reactivity and Blood Pressure Reactivity

NCT03564262
View directory record Official record
Conditions
Blood Pressure, Cerebrovascular Reactivity
Interventions
Low Sodium Meal (138 mg sodium), High Sodium Meal (1,495 mg sodium)
Other
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 45 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional

Human Sodium Balance Study

NCT04110262
View directory record Official record
Conditions
Hypertension
Interventions
High dietary sodium intake, Low dietary sodium intake
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2024 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Renal Salt Handling in Postural Tachycardia Syndrome Following Dietary Dopa Administration

NCT01064739
View directory record Official record
Conditions
Healthy Participants
Interventions
Fava beans, Fixed Sodium Diet
Dietary Supplement · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Sep 29, 2026, 2:11 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Salt and TH-17 in Healthy Human Subjects

NCT02261688
View directory record Official record
Conditions
Th17 Helper Immune Cells, Autoimmunity, Salt Intake, Sodium Chloride
Interventions
Low salt diet, Low salt diet + IV normal saline, Liberal salt diet
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Sep 29, 2026, 2:11 PM EDT
Not yet recruiting Not applicable Interventional

Nutrition Intervention Optimization to Better Utilize Resources and Support Health

NCT07713836
View directory record Official record
Conditions
Diabete Type 2, Obesity & Overweight, Nutritional Intervention, Food Insecurity
Interventions
Meal kits, No-prep meals, Culinary nutrition classes, Text messages
Behavioral
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Withdrawn Phase 4 Interventional

Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure

NCT06995144
View directory record Official record
Conditions
Heart Failure, Edema, Pulmonary Congestion, Fluid Overload
Interventions
Extended Release Torsemide Tablets, Immedate Release Torsemide Tablets
Drug
Lead sponsor
Sarfez Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional

Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID

NCT07745699
View directory record Official record
Conditions
Long COVID Fatigue
Interventions
Ketogenic Metabolic Therapy, Lifestyle Intervention
Other · Behavioral
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Family Sodium Watcher Program on Outcomes in Heart Failure Patient-Family Caregiver Dyads

NCT03560206
View directory record Official record
Conditions
Heart Failure
Interventions
Family SWaP intervention, usual care
Behavioral
Lead sponsor
Misook L. Chung
Other
Eligibility
21 Years to 90 Years
Enrollment
316 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 24, 2022 · Synced Sep 29, 2026, 2:11 PM EDT
Terminated Phase 1 Interventional

High Sodium Diet and External Abdominal Compression in POTS

NCT01771484
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
External automated abdominal binder
Device
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 60 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 29, 2026, 2:11 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

NCT04026776
View directory record Official record
Conditions
Salt; Excess, Blood Pressure Disorders
Interventions
Allopurinol, Dietary Intervention
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
22 Years to 33 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Recruiting Not applicable Interventional

Promoting Well-being and Health in Heart Failure

NCT04829617
View directory record Official record
Conditions
Heart Failure, Heart Failure NYHA Class I, Heart Failure NYHA Class II, Heart Failure NYHA Class III
Interventions
PP-MI Intervention, MI-alone Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 29, 2026, 2:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sodium Diet Effect on Aldosterone and Urinary RNA (SALTY)

NCT04168073
View directory record Official record
Conditions
Healthy
Interventions
High-sodium diet 300 mmol sodium/day, Low-sodium diet 10 mmol sodium/day
Other
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Sep 29, 2026, 2:11 PM EDT