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ClinicalTrials.gov public records Last synced Oct 8, 2026, 5:35 PM EDT

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Showing 121–144 of 392 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Low calorie diet Clear all
Active, not recruiting Not applicable Interventional

Investigating Metabolic and Psychological Adaptations in a Clinical Trial

NCT06800794
View directory record Official record
Conditions
Obesity and Type 2 Diabetes
Interventions
Behavioral Skill Training, Meal Provisioning
Behavioral · Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neurohormonal & Behavioral Correlates of Obesity and Weight Loss

NCT02063451
View directory record Official record
Conditions
Obesity
Interventions
Very Low Calorie Diet (VLCD)
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Early Phase 1 Interventional Results available

Pilot Study of Pazopanib With Low Fat Meal (PALM) in Advanced Renal Cell Carcinoma

NCT02729194
View directory record Official record
Conditions
Carcinoma, Renal Cell
Interventions
Pazopanib, Low Fat Diet
Drug · Other
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Oct 8, 2026, 5:35 PM EDT
Not yet recruiting Not applicable Interventional

"F!reF!ghterF!t": Lifestyle Coaching Interventions for Obese Firefighters (FireFit)

NCT06890975
View directory record Official record
Conditions
Obesity and Obesity-related Medical Conditions
Interventions
Lifestyle Coaching
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Sommerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Liver - Healthy Brain

NCT05216796
View directory record Official record
Conditions
Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease, NAFLD, Pre-diabetes
Interventions
Diet Intervention
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction

NCT03064932
View directory record Official record
Conditions
Cardiovascular Disease, Inflammation
Interventions
Controlled feeding diet
Other
Lead sponsor
Penn State University
Other
Eligibility
30 Years to 75 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2023 · Synced Oct 8, 2026, 5:35 PM EDT
Active, not recruiting Not applicable Interventional

Renal Oxygen Consumption, Insulin Sensitivity, and Daily Caloric Restriction in ADPKD

NCT06496542
View directory record Official record
Conditions
Autosomal Dominant Polycystic Kidney
Interventions
Daily caloric restriction, Standard advice control
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional

Low-Carbohydrate Diabetes Prevention Program Among Veterans With Prediabetes

NCT04881890
View directory record Official record
Conditions
PreDiabetes
Interventions
Low-Carbohydrate Diabetes Prevention Program
Behavioral
Lead sponsor
VA Ann Arbor Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Results available

Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease

NCT03342742
View directory record Official record
Conditions
Polycystic Kidney, Autosomal Dominant
Interventions
Weight Loss
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Daily Calorie or Alternate-day Calorie Reductions on Risk for Cardiovascular Disease and Cancer

NCT00467220
View directory record Official record
Conditions
Moderately Overweight Individuals
Interventions
calorie restriction
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
35 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Oct 8, 2026, 5:35 PM EDT
Terminated Phase 2 Interventional

Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus

NCT01083108
View directory record Official record
Conditions
Obesity, Bariatric Surgery, Morbid Obesity, Diabetes Mellitus Type 2, Diet Therapy
Interventions
Roux-en-Y Gastric Bypass, Caloric Restriction
Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
3
States / cities
Baltimore, Maryland • Bethesda, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional

Safety of Low and Very Low Carbohydrate Diets in Young Children With Type 1 Diabetes

NCT03862521
View directory record Official record
Conditions
Type 1 Diabetes Mellitus, Diet Modification, Child, Only
Interventions
Low carbohydrate diet, Very low carbohydrate diet
Other
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
2 Years to 11 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Oct 8, 2026, 5:35 PM EDT
Recruiting Not applicable Interventional

Support Through Remote Observation and Nutrition Guidance Program for Individuals With Gastroesophageal Cancer

NCT06497569
View directory record Official record
Conditions
GastroEsophageal Cancer
Interventions
Dietitian Consultation, Survey, Fitbit Data Collection, Referral to Dietitian, Social Determinants of Health Survey (SDOH)
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Tampa, Florida • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Phase 1 Interventional

RYGB and the Gastric Adipose Axis

NCT01474785
View directory record Official record
Conditions
Obesity
Interventions
human ghrelin, very low calorie diet, Hyperinsulinemic/Euglycemic Clamp
Drug · Other · Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Health at Every Size vs a Behavioral Weight Loss Approach for Obese Women

NCT00769717
View directory record Official record
Conditions
Obesity
Interventions
Wellness-Centered (HUGS), Weight-Centered (LEARN)
Behavioral
Lead sponsor
The Reading Hospital and Medical Center
Other
Eligibility
30 Years to 45 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
West Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Oct 8, 2026, 5:35 PM EDT
Enrolling by invitation Phase 4 Interventional

Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women

NCT07057310
View directory record Official record
Conditions
Obesity, Menopause
Interventions
semaglutide or tirzepatide, Lifestyle modification intervention
Drug · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
46 Years to 60 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional

The Healthy Eating and Active Living to Reverse Diabetes Pilot Study

NCT07316569
View directory record Official record
Conditions
Diabete Type 2, Diabetes, Overweight , Obesity
Interventions
Intensive Multicomponent Healthy Eating and Weight Loss Intervention, Enhanced Usual Diabetes Care
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Active, not recruiting Not applicable Interventional

Controlled Low Calorie Diet in Reducing Side Effects and Increasing Response to Chemotherapy in Patients With Breast or Prostate Cancer

NCT01802346
View directory record Official record
Conditions
Breast Cancer, Hormone-resistant Prostate Cancer, Recurrent Prostate Cancer
Interventions
dietary intervention, nutritional support, laboratory biomarker analysis
Dietary Supplement · Procedure · Other
Lead sponsor
University of Southern California
Other
Eligibility
19 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2027
U.S. locations
3
States / cities
Los Angeles, California • Newport Beach, California • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Recruiting Phase 2 Interventional

Control Systems Engineering for Weight Loss Maintenance

NCT06244888
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Intervention Targeting Stress and Emotion Regulation, Intervention Targeting Motivation and Self-efficacy for Weight Management, Intervention for Normalization of Eating, Intervention Targeting Physical Activity and Sleep
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 8, 2026, 5:35 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men

NCT04175678
View directory record Official record
Conditions
Healthy Lifestyle, Obese, Men
Interventions
Diet, Exercise, Standard care
Other
Lead sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Results available

Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans

NCT04259632
View directory record Official record
Conditions
Obesity
Interventions
Time Restricted Eating (TRE), Caloric Restriction (CR)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Characterization of Bile Acid Pathway in Obesity

NCT03341052
View directory record Official record
Conditions
Obesity
Interventions
Normal Diet, High Fat Diet, Low Fat Diet
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss

NCT01785719
View directory record Official record
Conditions
Weight Loss, Anovulation, Amenorrhea, Infertility
Interventions
Commercial Weight Loss Program
Behavioral
Lead sponsor
Cornell University
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Oct 8, 2026, 5:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Palatability (Energy I Pilot)

NCT01653886
View directory record Official record
Conditions
Energy Density
Interventions
Breakfast (1-2 hours, in the morning), Lunch (1-2 Hours, at midday), Dinner (1-2 hours, in the afternoon)
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 4, 2016 · Synced Oct 8, 2026, 5:35 PM EDT