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ClinicalTrials.gov public records Last synced Oct 19, 2026, 2:32 PM EDT

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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Low energy density Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Foundations for Health

NCT01304615
View directory record Official record
Conditions
Overweight, Obese
Interventions
Decrease Energy Density of the Diet, Increase Steps per Day, Consumption of Self-made Meals
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 2:32 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Low Energy Availability, Menstrual Irregularity, and Low Bone Mass

NCT01059968
View directory record Official record
Conditions
Bone Density, Energy Availability
Interventions
Not listed
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
15 Years to 17 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2011 · Synced Oct 19, 2026, 2:32 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Food Reinforcement, Weight Status, and Energy Density

NCT03981172
View directory record Official record
Conditions
Reinforcing Value of Food
Interventions
Daily snack food intake
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Energy and Physical Density Manipulation on Appetite

NCT05408390
View directory record Official record
Conditions
Appetite, Eating Behavior
Interventions
LPD+LED, HPD+LED, LPD+HED, HPD+HED
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Energy Density and Portion Size of Milk in Preschool Children

NCT02755558
View directory record Official record
Conditions
Feeding Behaviors
Interventions
Low energy density, High energy density, Small portion, Large portion
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 6 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alternative Dietary Approaches Online to Promote Tracking

NCT05049005
View directory record Official record
Conditions
Diet Quality, Weight Loss
Interventions
Simplified dietary tracking
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Effect of Varying Proportions of Low and High Energy Dense Foods Over 5 Days in Preschool Children

NCT03242863
View directory record Official record
Conditions
Feeding Behavior
Interventions
Food proportionality
Other
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 5 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Families Healthy Forces Study

NCT02348853
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Healthy Weight for Living (HWL), Current Best Practice (CBP)
Behavioral
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional

The Healthy Eating Choices for Life Program

NCT01096719
View directory record Official record
Conditions
Obesity
Interventions
Standard Behavioral Weight Loss Intervention, Dietary Goal: Reduction in Energy Density of Dietary Intake, Dietary Goal: Reduction of Energy Intake
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional

Modulating Energy Density in Time-Restricted Eating

NCT06259435
View directory record Official record
Conditions
Insulin Resistance, Body Weight
Interventions
Low-energy dense diet, Usual diet
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
50 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Not yet recruiting Phase 4 Interventional

Semaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitors

NCT07769047
View directory record Official record
Conditions
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
Interventions
Biospecimen Collection, Dual X-ray Absorptiometry, Functional Assessment, Lifestyle Counseling, Semaglutide
Procedure · Other · Behavioral + 1 more
Lead sponsor
Mayo Clinic
Other
Eligibility
46 Years to 55 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2035
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eat Well for Life: A Weight Loss Maintenance Study

NCT01849627
View directory record Official record
Conditions
Obesity
Interventions
Low-ED, Energy Balance
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 70 Years
Enrollment
345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lowering Caloric Density of the Diet

NCT02674971
View directory record Official record
Conditions
Obesity, Feeding Behavior
Interventions
Common components of intervention
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Active, not recruiting Not applicable Interventional Results available

Sickle Cell Disease (SCD) Bone Pain Study

NCT05283148
View directory record Official record
Conditions
Sickle Cell Disease, Sickle Cell Anemia, Low Bone Density, Osteoporosis, Osteopenia, Vertebral Fracture, Vertebral Compression, Osteonecrosis, Ischemic Necrosis, Avascular Necrosis
Interventions
Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism

NCT05290064
View directory record Official record
Conditions
Healthy Diet, Obesity
Interventions
Ultra-processed food, high energy density (UPF HL), Ultra-processed food, both low (UPF LL), Ultra-processed food, both high (UPF HH), Unprocessed food diet (UNF LL)
Other
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 60 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Recruiting Not applicable Interventional

The Combined Effects of Energy Density and Variety on Intake

NCT07663214
View directory record Official record
Conditions
Eating Behaviors
Interventions
Low Variety, High Variety, Low ED, High ED
Other
Lead sponsor
Cornell University
Other
Eligibility
20 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Quality Protein for Assisting With Weight Loss

NCT03085511
View directory record Official record
Conditions
Obesity
Interventions
Egg breakfast (EB), Weight Loss Counseling, Weight Loss Diet, Cereal Breakfast (CB)
Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Oct 19, 2026, 2:32 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Foods Within a Meal and Food Liking Study

NCT03783507
View directory record Official record
Conditions
Diet Habit, Obesity
Interventions
Order 1, Order 2, Order 3, Order 4
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 35 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eat Healthy for Families

NCT03394326
View directory record Official record
Conditions
Obesity, Childhood, Energy Density, Diet Quality
Interventions
family-based obesity prevention lifestyle intervention
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
2 Years to 5 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Portion Size Influence Intake of Low-Energy-Dense Foods in Preschool-aged Children?

NCT00936507
View directory record Official record
Conditions
Caloric Intake
Interventions
Energy Density/Portion Size
Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
3 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eating Behaviors Among Weight-Discordant Siblings

NCT01598389
View directory record Official record
Conditions
Obesity
Interventions
Feeding study
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
5 Years to 12 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 15, 2012 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Revitalize Cognition: Near Infrared Stimulation in Older Adults

NCT02582593
View directory record Official record
Conditions
Aging
Interventions
MedX 1116 Rehab Console, Sham MedX 1116 Rehab Console
Device
Lead sponsor
University of Florida
Other
Eligibility
62 Years to 99 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Portion Size and Energy Density of a Single Meal in Preschool Children

NCT02299531
View directory record Official record
Conditions
Feeding Behaviors
Interventions
Varying meal energy density and portion size
Other
Lead sponsor
Penn State University
Other
Eligibility
3 Years to 6 Years
Enrollment
131 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Oct 19, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ultherapy® for the Treatment of Erythematotelangiectatic Rosacea

NCT02144181
View directory record Official record
Conditions
Erythematotelangiectatic Rosacea, Rosacea
Interventions
Ulthera System Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
4
States / cities
Omaha, Nebraska • Wilmington, North Carolina • Hummelstown, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2018 · Synced Oct 19, 2026, 2:32 PM EDT