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ClinicalTrials.gov public records Last synced Oct 7, 2026, 9:57 PM EDT

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Showing 49–72 of 107 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Low intensity focused ultrasound Clear all
Terminated Phase 1Phase 2 Interventional

Ultrasonic Neuromodulation for Treatment of PTSD

NCT06135064
View directory record Official record
Conditions
PTSD
Interventions
Diadem
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 7, 2026, 9:57 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

tFUS Imaging & LIFU

NCT07222865
View directory record Official record
Conditions
Brain Imaging
Interventions
Feasibility of imaging using tFUS
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Phase 2 Interventional

Focused Ultrasound for PTSD in Veterans

NCT06820138
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Brainsonix Ultrasound Device
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Neuromodulation of Mind-Wandering in Depression

NCT04832685
View directory record Official record
Conditions
Depression
Interventions
BrainSonix Pulsar 1002
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Not yet recruiting Not applicable Interventional

Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke

NCT06875206
View directory record Official record
Conditions
Stroke, Visual Field Defect, Visual Field Defect Following Cerebrovascular Accident, Hemianopia, Quadrantanopia, Occipital Lobe Infarct, Visual Fields Hemianopsia
Interventions
Low-intensity focused ultrasound, Immersive virtual reality, Inactive Low-intensity focused ultrasound
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Suspended Not applicable Interventional

Low-Intensity Focused Ultrasound for Treatment-Resistant Depression

NCT06013384
View directory record Official record
Conditions
Major Depressive Disorder, Treatment Resistant Depression
Interventions
Low-Intensity Focused Ultrasound Pulsation, Sham Low-Intensity Focused Ultrasound Pulsation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

NCT06518785
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Ultrasound Stimulation for Patients in a Disorder of Consciousness

NCT06939348
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 79 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Pomona, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

NCT04557891
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Active LIFUP Treatment, Sham LIFUP Treatment
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
3
States / cities
Los Angeles, California • Boston, Massachusetts • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

NCT07207122
View directory record Official record
Conditions
Parkinson Disease
Interventions
Gen0Bh Transcranial Focused Ultrasound System (Active), Gen0Bh Transcranial Focused Ultrasound System (Sham)
Device
Lead sponsor
Sanmai Technologies PBC dba Sanmai
Industry
Eligibility
22 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Tucson, Arizona • Santa Monica, California • Gainesville, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Active, not recruiting Not applicable Interventional

Imaging-Guided Low Intensity Focused Ultrasound (LIFU)

NCT05467085
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
BX Pulsar 1002
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

NCT06906211
View directory record Official record
Conditions
Chronic Back Pain, Chronic Pain (Back / Neck)
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation

NCT03717922
View directory record Official record
Conditions
Brain Diseases, Memory Disorders, Learning Disabilities, Cognitive Impairment
Interventions
Low Intensity Focused Ultrasound Pulsation to Amygdala, Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
35 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 7, 2026, 9:57 PM EDT
Terminated Not applicable Interventional Results available

Feasibility of ExAblate MRI Guided High Intensity Focused Ultrasound Tx of Soft Tissue Tumors

NCT01965002
View directory record Official record
Conditions
Soft Tissue Neoplasms
Interventions
MRgHIFU, Aspirin, Enoxaparin
Device · Drug
Lead sponsor
Pejman Ghanouni
Other
Eligibility
10 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 23, 2018 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound (LIFU) Neuromodulation

NCT05997030
View directory record Official record
Conditions
Alzheimer Disease
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Ali Rezai
Other
Eligibility
45 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

LIFU for Treatment for Refractory Opioid Use Disorder

NCT06218706
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Low Intensity Focussed Ultrasound
Device
Lead sponsor
Ali Rezai
Other
Eligibility
22 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Not yet recruiting Not applicable Interventional

LIFU for Chronic Pain and Generalized Anxiety Disorder

NCT07686354
View directory record Official record
Conditions
Chronic Pain, Generalized Anxiety Disorder
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

NCT05495945
View directory record Official record
Conditions
Mental Function
Interventions
Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI) using Propofol
Device · Combination Product
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Phase 1 Interventional

Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma

NCT07343986
View directory record Official record
Conditions
Glioblastoma (GBM)
Interventions
anti-EGFR bispecific-armed T cells, Low-Intensity Focused Ultrasound
Drug · Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examination of Transcranial Focused Ultrasound on Brain Activity in Adults

NCT06477029
View directory record Official record
Conditions
Impulsive Behavior
Interventions
tFUS, Sham tFUS
Device
Lead sponsor
Mary Phillips, MD MD (Cantab)
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial

NCT03868293
View directory record Official record
Conditions
Drug Resistant Epilepsy
Interventions
Focused ultrasound
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

NCT04197921
View directory record Official record
Conditions
Opioid-use Disorder, Substance Use Disorders
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
4
States / cities
Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Investigating LIFUP in Anhedonic Depression

NCT06285474
View directory record Official record
Conditions
Depression, Anhedonia
Interventions
Low Intensity Focused Ultrasound Pulsation (LIFUP)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 7, 2026, 9:57 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function

NCT05194332
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
LIFUP sonication to the amygdala
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 7, 2026, 9:57 PM EDT