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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Terminated Not applicable Interventional Results available

Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)

NCT03209882
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD)
Interventions
TILS, sham
Device
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis

NCT05882812
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Not yet recruiting Phase 2 Interventional Accepts healthy volunteers

Long Duration High Frequency Ultrasound for the Treatment of Osteoarthritis

NCT07515872
View directory record Official record
Conditions
Arthritis, Osteo Arthritis of the Knee
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, Intra articular injection
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
65 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
2
States / cities
Stamford, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Sustained Acoustic Medicine Ultrasound Diathermy Clinical Performance

NCT05259995
View directory record Official record
Conditions
Measurement of Diathermy on Anatomical Locations of the Body
Interventions
Sustained Acoustic Medicine
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Trumbull, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Sep 4, 2026, 2:22 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture

NCT05883241
View directory record Official record
Conditions
Bone Fracture, Fresh Fracture
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, 2.5% Diclofenac Patches
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Trumbull, Connecticut • Lansdowne, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Dose-Dependent Effects of Low-Intensity Focused Ultrasound

NCT07099950
View directory record Official record
Conditions
Healthy Controls
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain

NCT05050448
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis

NCT04391842
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 1% Diclofenac patch
Combination Product
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
45 Years to 85 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Dryden, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

NCT05697172
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis

NCT06257537
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches, SAM Patch
Device · Drug · Other
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 4, 2026, 2:22 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Sustained Acoustic Medicine for Osteoarthritis Pain

NCT05254574
View directory record Official record
Conditions
Osteoarthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, 2.5% Diclofenac Patches
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Not listed Not applicable Interventional

Phoenix Thera-Lase for Treating Chronic Pain in Patients Taking Opioid on a PRN Basis

NCT02964000
View directory record Official record
Conditions
Pain
Interventions
Low level 1 Watt, Phoenix Thera-Lase System 42, Phoenix Thera-Lase System 74
Device
Lead sponsor
Phoenix Thera-lase Systems, LLC
Industry
Eligibility
25 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Sep 4, 2026, 2:22 PM EDT
Terminated Not applicable Interventional Results available

Photobiomodulation for the Management of Temporomandibular Disorder Pain

NCT04415281
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system, sham THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Sep 4, 2026, 2:22 PM EDT
Active, not recruiting Phase 1 Interventional

Cryotherapy for Locally Advanced Esophageal Cancer

NCT04248582
View directory record Official record
Conditions
Esophageal Cancer
Interventions
Cryotherapy
Device
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 4, 2026, 2:22 PM EDT
Recruiting Not applicable Interventional

Photobiomodulation for Management of Temporomandibular Disorder Pain

NCT05916235
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Not applicable Interventional Results available

Wearable LITUS Device for Osteoarthritis of the Knee: a Randomized Double-Blind Placebo-Controlled Trial

NCT02083861
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Sam Ultrasonic Diathermy Device
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Dryden, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Sep 4, 2026, 2:22 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of LASER Photobiomodulation Therapy on Chronic Pain and Opioid Weaning

NCT03437967
View directory record Official record
Conditions
Chronic Pain
Interventions
LightForce EXPi
Device
Lead sponsor
LiteCure LLC
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 25, 2019 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparative Evaluation of Sustained Acoustic Medicine Device on Circulation

NCT06510062
View directory record Official record
Conditions
Measurement of Circulation on Anatomical Locations of the Body
Interventions
Sustained Acoustic Medicine, 2.5% Diclofenac Patches
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Trumbull, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers

NCT03830892
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
E-cigarette Lab Session 15 watts, 10 mg nicotine, E-cigarette Lab Session 15 watts, 30 mg nicotine, E-cigarette Lab Session 30 watts, 10 mg nicotine, E-cigarette Lab Session 30 watts, 30 mg nicotine, Own Brand Session - E-cigarette, Own Brand Session - E-cigarette/Cigarette
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Sep 4, 2026, 2:22 PM EDT
Terminated Not applicable Interventional

Low Level Laser Therapy (LLLT) for the Treatment of Hand Osteoarthritis.

NCT04692597
View directory record Official record
Conditions
Low Level Laser Therapy, Osteoarthritis, Family Medicine, Pain Management, Integrative Medicine
Interventions
Phoenix Thera-Lase System, SHAM Phoenix Thera-Lase System
Device
Lead sponsor
David Moss
Federal
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Nellis Air Force Base, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 4, 2026, 2:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults

NCT05131217
View directory record Official record
Conditions
Aging Well
Interventions
Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
Other
Lead sponsor
University of Virginia
Other
Eligibility
65 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Sep 4, 2026, 2:22 PM EDT