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ClinicalTrials.gov public records Last synced Nov 4, 2026, 10:32 PM EST

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Showing 1–24 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Low level nicotine cigarette Clear all

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 70 Years
Enrollment: 775 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Nicotine Dependence, Other Tobacco Product
Interventions: Nicotine, Low Dose Menthol, High Dose Menthol; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking Cessation, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction
Interventions: ACT Lung Health Intervention; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years to 100 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Tobacco Dependence
Interventions: Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 70 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Healthy
Interventions: Wear clothing that has been exposed to cigarette smoke for 3 hours.; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 50 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Cigarette, Electronic Cigarettes
Interventions: Spectrum Research Cigarettes; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 15 Years to 20 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking Behavior
Interventions: Control, Product Category Score, Product Category Rank, Product Tiers; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking
Interventions: Very low nicotine content cigarettes, Normal nicotine content cigarettes; Drug
Lead sponsor: Saul Shiffman; Other
Eligibility: 18 Years and older
Enrollment: 312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Tobacco Smoking Behavior
Interventions: Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Tobacco Products, Smoking Behavior, Cigarette Use
Interventions: VLNC messages, Control message; Behavioral
Lead sponsor: Georgia State University; Other
Eligibility: 21 Years and older
Enrollment: 1,230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Cigarette Smoking
Interventions: Harm Reduction Tax - Normal Nicotine Cigarettes Available, Harm Reduction Tax - Normal Nicotine Cigarettes Not Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Not Available, Nicotine Content Tax - Normal Nicotine Cigarettes Available, Nicotine Content Tax - Normal Nicotine Cigarettes Not Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Not Available; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Buffalo, New York • Roanoke, Virginia

Conditions: Tobacco Dependence
Interventions: very low nicotine content cigarettes; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 839 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 9
States / cities: San Francisco, California • Tampa, Florida • Baltimore, Maryland + 6 more

Conditions: Tobacco Use Disorder
Interventions: Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 235 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: Duluth, Minnesota • Minneapolis, Minnesota

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Lexington, Kentucky • Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: Nicotine; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2016
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Smoking, Cigarette, Nicotine Dependence
Interventions: Nicotine (electronic cigarette), Nicotine (nicotine pouch); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking
Interventions: Not listed
Lead sponsor: National Institute on Minority Health and Health Disparities (NIMHD); NIH
Eligibility: 21 Years to 120 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Nicotine Dependence
Interventions: Nicotine, Experimental Flavor, Menthol Flavor; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking, Drug Use
Interventions: Standard Treatment, BAD-AS, Transdermal Nicotine Patch; Behavioral · Drug
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years to 65 Years
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 775 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions: Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking
Interventions: Deuterated nicotine and cotinine; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 65 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Smoking Cessation
Interventions: Tobacco Treatment; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 706 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Electronic Cigarette Use
Interventions: Low strength nicotine e-liquid, High strength nicotine e-liquid; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Search by objective public record fields.

Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

ACT Lung Health Intervention: Phase Two

Low Nicotine Cigarettes Plus Electronic Cigarettes

Melanin and Dermal Uptake of Thirdhand Cigarette Smoke

Evaluating New Nicotine Standards for Cigarettes - Project 3

Effects of Tobacco Abuse Liability-dependent Taxes in the ETM

Very-Low Nicotine Cigarettes and Non-Daily Smokers

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

Communicating About Nicotine Reduction in Cigarettes

Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing

Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

Innovative Interventions for Smoking Cessation

Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women

Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

Using Smartwatches to Monitor Smoking in Real-life Situations

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment

Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

Comparison of Low Yield Cigarettes in African Americans vs. Whites

Tobacco Treatment Outreach to Reduce Disparities for Primary Care Populations

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors