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ClinicalTrials.gov public records Last synced Nov 5, 2026, 4:44 AM EST

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Showing 49–72 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Low level nicotine cigarette Clear all

Conditions: E-cigarette Use
Interventions: ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 25 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoking
Interventions: Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (0.07 mg), MCE-; Drug · Behavioral
Lead sponsor: Francis McClernon, Ph.D.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 87 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco-Related Carcinoma
Interventions: Biospecimen Collection, Carbon Monoxide Measurement, Vaping session, Survey Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 375 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions: Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 50 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Pain, Tobacco Use, Opioid Substitution Treatment
Interventions: Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC); Behavioral
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence, Cigarettes, Uncomplicated
Interventions: Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes; Drug
Lead sponsor: Brown University; Other
Eligibility: 15 Years to 20 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Electronic Cigarettes
Interventions: E-cigarette Lab Session 15 watts, 10 mg nicotine, E-cigarette Lab Session 15 watts, 30 mg nicotine, E-cigarette Lab Session 30 watts, 10 mg nicotine, E-cigarette Lab Session 30 watts, 30 mg nicotine, Own Brand Session - E-cigarette, Own Brand Session - E-cigarette/Cigarette; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking
Interventions: Modified Natural American Spirit-Tan or Green cigarettes injected with labeled NNK; Combination Product
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Cigarette Smoking, Smoking Behaviors
Interventions: Very low nicotine cigarette: menthol, Very low nicotine cigarette: non-mentol; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 34 Years
Enrollment: 171 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Electronic Cigarette Use
Interventions: E-cigarette Flavor, Tobacco Free Nicotine Pouch; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Nicotine Dependence
Interventions: Nicotine; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2016
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Tobacco Smoking, Nicotine Dependence
Interventions: Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 799 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more

Conditions: Tobacco Use Disorder
Interventions: Nicotine Patch, Sustained Release Bupropion; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 45 Years
Enrollment: 594 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Smoking
Interventions: Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling; Drug · Behavioral
Lead sponsor: Maggie M Sweitzer, PhD; Other
Eligibility: 18 Years to 55 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcohol Use, E-cigarette Use, Cigarette Use
Interventions: Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks; Behavioral
Lead sponsor: Mark J Rzeszutek, PhD; Other
Eligibility: 21 Years and older
Enrollment: 737 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Nicotine Dependence, Tobacco Smoking
Interventions: Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 1,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 10
States / cities: Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT); Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tobacco Use, Cigarette Use
Interventions: Very Low Nicotine Cigarette, Reduced nicotine regulatory environment, Restriction on characterizing flavors in combustible nicotine products, Restriction on characterizing flavors in noncombustible nicotine products; Drug · Behavioral
Lead sponsor: Mikhail N Koffarnus; Other
Eligibility: 21 Years and older
Enrollment: 473 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Tobacco Dependence
Interventions: Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Chronic Pain, Smoking, Cigarette
Interventions: SPECTRUM NRC 102/103 investigational cigarettes, SPECTRUM NRC 600/601 investigational cigarettes; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: X-22 Smoking Cessation Product, Active Control Cigarettes; Drug
Lead sponsor: 22nd Century Limited, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 3
States / cities: Sacramento, California • Metairie, Louisiana • Austin, Texas

Conditions: Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Nicotine Dependence
Interventions: Varenicline; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 70 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Cigarette Smoking, Nicotine Dependence, Smoking Cessation
Interventions: High Nicotine Dose, Low Nicotine Dose; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: THC, Cannabis, Cannabis Use, Cannabis Smoking, Tobacco Use, Vaping
Interventions: Cannabis, Nicotine, Pax Loose Leaf Vaporizer, Placebo Marijuana; Drug · Device · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)

Manipulating E-Cigarette Nicotine to Promote Public Health

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers

Metabolism of NNK in Japanese Americans

Cigarette Smoking Among Young Adults

Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems

Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

Project 2: Strategies for Reducing Nicotine Content in Cigarettes

Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco Marketplace

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

Low Nicotine Cigarettes, Smoking, and Chronic Pain

Randomized Trial to Evaluate the Effectiveness of X-22 as a Smoking Cessation Aid

Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration