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ClinicalTrials.gov public records Last synced Nov 5, 2026, 5:36 AM EST

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Showing 73–96 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Low level nicotine cigarette Clear all

Conditions: Alcohol Dependence, Nicotine Dependence
Interventions: Low-Dose Topiramate, Placebo, High-Dose Topiramate; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 4
States / cities: La Jolla, California • Houston, Texas • Charlottesville, Virginia + 1 more

Conditions: Nicotine Dependence
Interventions: Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch, Placebo Patch; Device · Other · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 209 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
Interventions: EQUIP, Standard Care; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 26 Years
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tobacco Use Cessation
Interventions: 1-Call Quitline Counseling, 4-Call Quitline Counseling, Nicotine patch, Nicotine Patch and Nicotine Lozenge, SmokefreeTXT, No SmokefreeTXT, Financial Incentives for Treatment Engagement, No Financial Incentives for Treatment Engagement; Behavioral · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1,316 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Use
Interventions: Not listed
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Tobacco Use Cessation
Interventions: QuitAid, SmokefreeTXT, Nicotine Replacement Therapy Patch, Nicotine lozenge; Behavioral · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Cigarette Smoking
Interventions: Low-nitrosamine smokefree tobacco product for oral use, Non-tobacco, non-nicotine placebo product; Drug · Other
Lead sponsor: Swedish Match AB; Industry
Eligibility: 25 Years to 65 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 4
States / cities: Daytona Beach, Florida • Evansville, Indiana • Portland, Oregon + 1 more

Conditions: Cigarette Smoking
Interventions: Quest; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 246 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Drinking, Cigarette Smoking Toxicity
Interventions: Reduced nicotine cigarettes; Drug
Lead sponsor: Battelle Memorial Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking, Smoking Cessation
Interventions: Coordinated Care, Usual Care; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 633 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Nicotine, behavioral counseling for smoking cessation; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking, Tobacco Use
Interventions: Low Power, High Power, Low Concentration, High Concentration; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Nicotine Withdrawal, Nicotine Addiction, Drug Effect
Interventions: Nicotine, Cigarette; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cannabis, Nicotine
Interventions: Cannabis, Nicotine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use
Interventions: VLN cigarettes (A), Usual Brand Cigarettes (B), Nicotine gum (C); Other · Drug
Lead sponsor: 22nd Century Group, Inc.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Smoking
Interventions: Normal nicotine content cigarettes (NNC, Baseline), Very low nicotine content (VLNC); Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions: very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Healthy Adult Participants
Interventions: 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches, cigarette or e-cigarette; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Cigarette
Interventions: Low Nicotine Content Cigarettes, Control message, Test message; Drug · Other
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking
Interventions: Nicotine content; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years to 29 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Cigarette
Interventions: LNC Cigarettes + Colored Packaging, Own Brand; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years to 65 Years
Enrollment: 219 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: Low nicotine cigarettes; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 207 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence, ADHD
Interventions: Very low nicotine content cigarettes, Conventional nicotine content cigarettes; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Durham, North Carolina • Pittsburgh, Pennsylvania

Conditions: Tobacco Use
Interventions: Non-Menthol Very Low Nicotine Cigarettes, Menthol Very Low Nicotine Cigarettes, Subject's UB non-mentholated filtered cigarettes, Subject's UB mentholated filtered cigarettes; Other
Lead sponsor: 22nd Century Group, Inc.; Industry
Eligibility: 26 Years to 65 Years
Enrollment: 142 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Lincoln, Nebraska • High Point, North Carolina

Search by objective public record fields.

New Treatment for Alcohol and Nicotine Dependence

Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

Improving Quitline Support Study

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

Feasibility of Delivering VergeRx at FQHCs

Controlled Study of the Ability of a Smokefree Tobacco Product to Increase the Quit Rate Among Cigarette Smokers

Use and Harm Exposure in New Low Nicotine Cigarettes

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder

Connect to Quit for Smoking

Very Low-Nicotine Cigarettes in Smokers With SUD

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers

Behavioral Pharmacology of Cannabis and Nicotine

Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes

Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

Understanding Oral Nicotine Pouch Use in Healthy Volunteers

Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices

Young Adults and Low Nicotine Cigarettes

Cigarette Packaging of Low Nicotine Cigarettes

Nicotine Metabolism and Low Nicotine Cigarettes

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes