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ClinicalTrials.gov public records Last synced Nov 5, 2026, 8:39 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–117 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Low level nicotine cigarette Clear all

Conditions: Smoking
Interventions: Very low nicotine content cigarettes, Normal nicotine content cigarettes; Drug
Lead sponsor: Saul Shiffman; Other
Eligibility: 18 Years and older
Enrollment: 312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking Cessation
Interventions: Questionnaire, In-Depth Interviews, Breath Test, Nicotine Patches, Advice plus Phone Counseling, Advice plus Counseling Sessions, Self Assessment Questionnaires; Behavioral · Other · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 25 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nicotine Dependence, Cigarettes, Uncomplicated
Interventions: Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes; Drug
Lead sponsor: Brown University; Other
Eligibility: 15 Years to 20 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking Behavior
Interventions: Control, Product Category Score, Product Category Rank, Product Tiers; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: THC, Cannabis, Cannabis Use, Cannabis Smoking, Tobacco Use, Vaping
Interventions: Cannabis, Nicotine, Pax Loose Leaf Vaporizer, Placebo Marijuana; Drug · Device · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence
Interventions: Standard treatment, Standard treatment+practice quitting, Very low nicotine cigarettes; Behavioral · Drug
Lead sponsor: Rutgers University; Other
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Nicotine Dependence
Interventions: Nicotine, behavioral counseling for smoking cessation; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Addiction, Dual Tobacco Use
Interventions: VLNC cigarettes, Combusted Products, Non-combusted products, CN cigarettes; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 136 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking, E-cigarette Use
Interventions: Nicotine Content, Illegal cigarette price, E-cigarette price; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Cannabis Use, Tobacco Use, Cigarette Smoking
Interventions: THC 30mg, THC 5mg, THC 0mg, Cigarette Full Nicotine, Cigarette Reduced Nicotine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Sudden Cardiac Death, Prolonged QTc Interval
Interventions: EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Alcohol Dependence, Nicotine Dependence
Interventions: Low-Dose Topiramate, Placebo, High-Dose Topiramate; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 4
States / cities: La Jolla, California • Houston, Texas • Charlottesville, Virginia + 1 more

Conditions: Cigarette Smoking, Smoking Behaviors
Interventions: Very low nicotine cigarette: menthol, Very low nicotine cigarette: non-mentol; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 34 Years
Enrollment: 171 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
Interventions: Brief Intervention with NRT Initiation; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Cessation
Interventions: QuitAid, SmokefreeTXT, Nicotine Replacement Therapy Patch, Nicotine lozenge; Behavioral · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tobacco Use Disorder/Cigarette Smoking
Interventions: Working Memory Training + Behavioral Intervention; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Nicotine Use Disorder
Interventions: E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1), E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2), E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2), E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2), E-liquid coolant (High [2.0%] WS-3) for non-menthol (3), E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3), E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3), E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4), E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4), E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4), E-liquid coolant (High [2.0%] WS-23) for non-menthol (5), E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5), E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5), E-liquid coolant (4% WS-23) for non-menthol (6), E-liquid coolant (4% WS-23) for low (0.1%) menthol (6), E-liquid coolant (4% WS-23) for high (2.0%) menthol (6); Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking, Smoking Cessation
Interventions: Tobacco Treatment; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 706 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: Low nicotine cigarettes; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 207 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Tobacco Use
Interventions: Low Power, High Power, Low Concentration, High Concentration; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Dependence
Interventions: Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Search by objective public record fields.

Very-Low Nicotine Cigarettes and Non-Daily Smokers

Health Literacy and Smoking Cessation in Low-SES Diverse Smokers - Project HALT II

Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco

Effects of Tobacco Abuse Liability-dependent Taxes in the ETM

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Evaluation of Learning-Theory-Based Smoking Cessation Strategies

Very Low-Nicotine Cigarettes in Smokers With SUD

Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

Effect of Cannabis on Cigarette Use Behavior

Smoking and Ventricular Repolarization

New Treatment for Alcohol and Nicotine Dependence

Cigarette Smoking Among Young Adults

Treating Low-Income Smokers in the Hospital Emergency Department

Feasibility of Delivering VergeRx at FQHCs

Working Memory Training on Delay Discounting Among Cigarette Smokers

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Tobacco Treatment Outreach to Reduce Disparities for Primary Care Populations

Nicotine Metabolism and Low Nicotine Cigarettes

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine