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ClinicalTrials.gov public records Last synced Sep 22, 2026, 2:03 AM EDT

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Showing 1–24 of 103 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Low-intensity Focused Ultrasound Clear all
Enrolling by invitation Not applicable Interventional

Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy

NCT07353918
View directory record Official record
Conditions
Epilepsy (Treatment Refractory), Epilepsy Comorbidities
Interventions
Low-intensity Focused Ultrasound, Sham
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Terminated Phase 1Phase 2 Interventional

Ultrasonic Neuromodulation for Treatment of Cognitive Impairment

NCT06135051
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Cognitive Impairment
Interventions
Diadem prototype
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

NCT04197921
View directory record Official record
Conditions
Opioid-use Disorder, Substance Use Disorders
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
4
States / cities
Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

NCT06906211
View directory record Official record
Conditions
Chronic Back Pain, Chronic Pain (Back / Neck)
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Double Arm Pivotal Study to Evaluate the Neurolyser XR for the Treatment of Chronic Low Back Pain

NCT05154448
View directory record Official record
Conditions
Facet Syndrome of Lumbar Spine
Interventions
Non-Invasive Thermal Ablation of the Medial Branch Nerves (Neurolyser XR), Sham procedure
Device · Other
Lead sponsor
FUSMobile Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
10
States / cities
Stamford, Connecticut • Jacksonville, Florida • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 22, 2026, 2:03 AM EDT
Completed Phase 2 Interventional Results available

Focused Ultrasound Modulation of the Globus Pallidus Interna in Schizophrenia

NCT05643196
View directory record Official record
Conditions
Schizophrenia, Schizophrenia Schizoaffective
Interventions
PLIFUS, Sham PLIFUS, MRI
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Sep 22, 2026, 2:03 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cerebellar Functions in Visuomotor Adaptation

NCT04168086
View directory record Official record
Conditions
Healthy Participants
Interventions
Focused Ultrasound, Sham
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 35 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional

Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering

NCT07668882
View directory record Official record
Conditions
Stuttering, Developmental Stuttering
Interventions
High DC LIFU, Sham
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

NCT07221539
View directory record Official record
Conditions
Mental Function
Interventions
Propofol for fMRI, Dexmedetomidine for fMRI, Dorsolateral prefrontal cortex (DLPFC) pulsation, Anterior insular cortex (AIC) pulsation, Central thalamus (CT) pulsation
Procedure · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 22, 2026, 2:03 AM EDT
Terminated Not applicable Interventional Results available

Thalamic Low Intensity Focused Ultrasound in Brain Injury

NCT02522429
View directory record Official record
Conditions
Consciousness Disorders, Brain Injuries
Interventions
Low Intensity Focused Ultrasound Device
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Sep 22, 2026, 2:03 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

The LINFU® U.S. Registry in Patients With IPMN (Intraductal Papillary Mucinous Neoplasm of the Pancreas)

NCT06276764
View directory record Official record
Conditions
IPMN, Pancreatic, Pancreas Cancer, Pancreatic Cyst
Interventions
LINFU®
Diagnostic Test
Lead sponsor
Adenocyte, LLC
Industry
Eligibility
18 Years to 90 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2034
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Terminated Phase 1Phase 2 Interventional

Ultrasonic Neuromodulation for Treatment of PTSD

NCT06135064
View directory record Official record
Conditions
PTSD
Interventions
Diadem
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Early Phase 1 Interventional

Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor

NCT07599592
View directory record Official record
Conditions
Essential Tremor
Interventions
Low Intensity Focused Ultrasound (LIFU)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Not listed Not applicable Interventional

Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain

NCT05751096
View directory record Official record
Conditions
Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain
Interventions
Low-intensity Focused Ultrasound (LIFU), Sham Low-intensity focused ultrasound (LIFU)
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Sep 22, 2026, 2:03 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Low-intensity Focused Ultrasound and Autonomic Response

NCT05834829
View directory record Official record
Conditions
Autonomic Dysfunction
Interventions
Low-intensity focused ultrasound neuromodulation, Sham Low-intensity focused ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans

NCT07508722
View directory record Official record
Conditions
Healthy Volunteers, no Condition, Basic Science
Interventions
Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional

Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

NCT07680842
View directory record Official record
Conditions
Drug-Resistant Epilepsy, Epilepsy, Epilepsy (Treatment Refractory), Epilepsy Comorbidities, Epilepsy, Drug Resistant, Epilepsy, Generalized, Epilepsy, Focal
Interventions
Target optimization using LIFU, Serial LIFU stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Not yet recruiting Not applicable Interventional

LIFU for Chronic Pain and Generalized Anxiety Disorder

NCT07686354
View directory record Official record
Conditions
Chronic Pain, Generalized Anxiety Disorder
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Investigation of Low-intensity Focused Ultrasound Pressure

NCT06343883
View directory record Official record
Conditions
Somatic Pain
Interventions
low-intensity focused ultrasound - low pressure, low-intensity focused ultrasound - medium pressure, low-intensity focused ultrasound - high pressure
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Active, not recruiting Early Phase 1 Interventional

Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder

NCT06482762
View directory record Official record
Conditions
Bipolar
Interventions
BrainSonix Pulsar 1002
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

NCT04557891
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Active LIFUP Treatment, Sham LIFUP Treatment
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
3
States / cities
Los Angeles, California • Boston, Massachusetts • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial

NCT03868293
View directory record Official record
Conditions
Drug Resistant Epilepsy
Interventions
Focused ultrasound
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Recruiting Phase 1 Interventional

Sonodynamic Therapy in Patients With Recurrent GBM

NCT06039709
View directory record Official record
Conditions
Recurrent Glioblastoma, Glioblastoma Multiforme, GBM
Interventions
5-ALA and Low-Intensity Focused Ultrasound (SDT)
Combination Product
Lead sponsor
Shayan Moosa, MD
Other
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 22, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)

NCT06612788
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 22, 2026, 2:03 AM EDT