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Showing 1–24 of 131 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Low-salt diet Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Sodium Intake on Calcium Retention in Girls

NCT01564238
View directory record Official record
Conditions
Osteoporosis
Interventions
Low Na diet (1.3 g/d), High sodium diet (3.8 g/d)
Other
Lead sponsor
Purdue University
Other
Eligibility
11 Years to 15 Years · Female only
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2000
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Sep 10, 2026, 10:14 PM EDT
Terminated Phase 4 Interventional

Sodium Restriction in the Management of Cirrhotic Ascites

NCT00548366
View directory record Official record
Conditions
Ascites
Interventions
Sodium restriction
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 13, 2010 · Synced Sep 10, 2026, 10:14 PM EDT
Recruiting Not applicable Interventional

Mediterranean Diet Post-liver Transplantation

NCT04672863
View directory record Official record
Conditions
Liver Transplantation
Interventions
Dietary Intervention
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional

Geriatric Out of Hospital Randomized Meal Trial in Heart Failure

NCT02148679
View directory record Official record
Conditions
Heart Failure
Interventions
DASH/SRD, Usual care
Other
Lead sponsor
University of Michigan
Other
Eligibility
55 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Ann Arbor, Michigan • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 26, 2017 · Synced Sep 10, 2026, 10:14 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults

NCT07649005
View directory record Official record
Conditions
Healthy Older Adults
Interventions
low sodium/low potassium diet, high sodium/low potassium diet, high sodium/high potassium diet
Other
Lead sponsor
Florida State University
Other
Eligibility
55 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 10, 2026, 10:14 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

NCT04026776
View directory record Official record
Conditions
Salt; Excess, Blood Pressure Disorders
Interventions
Allopurinol, Dietary Intervention
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
22 Years to 33 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women

NCT04266704
View directory record Official record
Conditions
Hypertension
Interventions
Sharing Intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 10, 2026, 10:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

DASH-Sodium Trial in Adolescents

NCT02993458
View directory record Official record
Conditions
Blood High Pressure
Interventions
DASH diet, Low Na diet, High Na diet, Usual Diet
Other
Lead sponsor
Purdue University
Other
Eligibility
11 Years to 15 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Indianapolis, Indiana • West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 7, 2017 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Salt in Postural Tachycardia Syndrome

NCT01547117
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
Blood Volume, Total Blood Volume, Exercise Capacity Test - Bicycle, Posture Study
Radiation · Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 50 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 21, 2022 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

ANX-042 Healthy Volunteer Dose Escalation Study

NCT01638104
View directory record Official record
Conditions
Healthy Volunteers
Interventions
ANX-042, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
19 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low Sodium Diet and Behavioral Intervention for Reversing Arterial Stiffening in Overweight Individuals

NCT00366990
View directory record Official record
Conditions
Cardiovascular Diseases, Obesity
Interventions
Low Sodium Diet, Regular Sodium Intake
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
20 Years to 45 Years
Enrollment
349 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional

A Trial to Evaluate Medically Tailored Meals With Patients With Heart Failure

NCT04289181
View directory record Official record
Conditions
Heart Failure
Interventions
Medically Tailored Meals
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients

NCT00689819
View directory record Official record
Conditions
Hypertension, High Blood Pressure, Ventricular Hypertrophy, Diastolic Dysfunction, Systolic Dysfunction
Interventions
Exercise, Weight Loss, Low Sodium Diet, Smoking Cessation, Pharmaceutical Therapy (no specific therapy; approach guided by the JNC 7 protocol guidelines)
Behavioral · Drug
Lead sponsor
Wayne State University
Other
Eligibility
35 Years to 75 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2013 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Results available

Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure

NCT00939640
View directory record Official record
Conditions
Diastolic Heart Failure, Hypertensive Heart Disease
Interventions
DASH/sodium-restricted diet (SRD)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Sep 10, 2026, 10:14 PM EDT
Withdrawn Not applicable Interventional

Software Application for Low-Sodium Diet Trial (SALT)

NCT04438551
View directory record Official record
Conditions
Kidney Stone, Hypernatriuria
Interventions
Standard dietary counseling, Mobile app
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Renal Salt Handling in Postural Tachycardia Syndrome Following Dietary Dopa Administration

NCT01064739
View directory record Official record
Conditions
Healthy Participants
Interventions
Fava beans, Fixed Sodium Diet
Dietary Supplement · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional

Role of Exercise in Diastolic Heart Failure

NCT01047631
View directory record Official record
Conditions
Diastolic Heart Failure, Heart Failure With Preserved Ejection Fraction
Interventions
Functional circuit training and lifestyle counseling, Health education and independent walking
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 10, 2026, 10:14 PM EDT
Recruiting Not applicable Interventional

CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

NCT05996328
View directory record Official record
Conditions
Heart Failure
Interventions
Home-delivered meals and short-term dietary counseling, Study -defined standard of care
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years and older
Enrollment
1,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
16
States / cities
Birmingham, Alabama • Long Beach, California • Palo Alto, California + 13 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.

NCT06449287
View directory record Official record
Conditions
Ketogenic Diet, Weight Loss
Interventions
Diet, Blood Draw, Ketone/Glucose Monitoring, Body Composition, Urine Analysis, Neuropsychological Measures - ANAM
Other · Biological · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet

NCT01324245
View directory record Official record
Conditions
Salt-sensitive Hypertension
Interventions
Fenoldopam
Drug
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 27, 2011 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional

Volume,Sodium and Blood Pressure Management in HD

NCT01766882
View directory record Official record
Conditions
End Stage Renal Failure
Interventions
Lower sodium intervention, Progressive Challenge to Post Dialysis Weight
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Ann Arbor, Michigan • Livonia, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Shifting Salty Taste Preferences in Children

NCT02909764
View directory record Official record
Conditions
Development
Interventions
Low Sodium Group
Other
Lead sponsor
Monell Chemical Senses Center
Other
Eligibility
7 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 29, 2019 · Synced Sep 10, 2026, 10:14 PM EDT
Withdrawn Not applicable Interventional

Tissue Sodium in Autoimmune Disease

NCT02525835
View directory record Official record
Conditions
Systemic Lupus Erythematosus
Interventions
Low Dietary Sodium, High Dietary Sodium
Dietary Supplement
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Sep 10, 2026, 10:14 PM EDT
Completed Not applicable Interventional Results available

Orthostatic Hypotension Treatment on Rehab Unit

NCT01030874
View directory record Official record
Conditions
Orthostatic Hypotension, Falls
Interventions
Medication review, Nutrition/Salt intake, Education, Exercise, Drug Recommendations
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 99 Years
Enrollment
356 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 10, 2026, 10:14 PM EDT