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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Lumbar Manipulation Clear all
Completed Not applicable Interventional

Lumbar Manipulation and Exercise for the Treatment of Acute Low Back Pain in Adolescents

NCT02111278
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham Manipulation, Physical Therapy
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
13 Years to 17 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
3
States / cities
Columbus, Ohio • Westerville, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Dry Needling and Spinal Manipulation vs. Conventional PT for Lumbar Spinal Stenosis

NCT03167736
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
electric dry needling, manipulation, conventional physical therapy
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
50 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Canton, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment

NCT02848456
View directory record Official record
Conditions
Subluxation of Joint of Lumbar Spine
Interventions
Spinal Manipulation, Max Voluntary Isometric Contraction, SM+MVIC
Procedure
Lead sponsor
Grant Sanders
Other
Eligibility
20 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Results available

Assessment of Chiropractic Treatment Using Reaction and Response Times in Members of the Special Operation Forces (ACT2)

NCT02168153
View directory record Official record
Conditions
Physiological Measurements of Response and Reaction Times
Interventions
Chiropractic Manipulative Therapy, Wait-list
Other
Lead sponsor
RAND
Other
Eligibility
20 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fort Campbell North, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of the Effect of Spine Grade I and II Manipulation and a PNE Video on Brainwaves: Pilot Study

NCT04908670
View directory record Official record
Conditions
Chronic Pain, Manipulation, Psychologic
Interventions
Understanding Pain in less than 5 minutes, and what to do about it! https://www.youtube.com/watch?v=C_3phB93rvI, PA manipulation
Behavioral · Procedure
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
20 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Merrillville, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 22, 2026, 7:37 AM EDT
Recruiting Not applicable Interventional

How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care.

NCT06495021
View directory record Official record
Conditions
Pneumonia, Sinusitis, Bronchitis, Respiratory Disease, Respiratory Tract Infections
Interventions
Lymphatic Pump Osteopathic Manipulative Therapy
Procedure
Lead sponsor
Geisinger Clinic
Other
Eligibility
65 Years to 100 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Bloomsburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 22, 2026, 7:37 AM EDT
Terminated Not applicable Interventional

Influence of Opioid Use on the Effects of Spinal Manipulative Therapy for Low Back Pain

NCT03749564
View directory record Official record
Conditions
Low Back Pain, Opioid Use
Interventions
SMT, Activation Exercises, Mobilizing Exercises, Extended SMT
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 22, 2026, 7:37 AM EDT
Not listed Not applicable Interventional

Korean Medicine for Symptomatic Lumbar Spinal Spondylolisthesis

NCT03107468
View directory record Official record
Conditions
Spondylolisthesis, Lumbosacral Region
Interventions
Mokhuri intensive treatment, Non-surgical conventional standard treatment
Other
Lead sponsor
Kim Ki Ok
Other
Eligibility
19 Years to 78 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Sep 22, 2026, 7:37 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response

NCT00601341
View directory record Official record
Conditions
Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
Interventions
lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Sep 22, 2026, 7:37 AM EDT
Withdrawn Not applicable Interventional

Mastalgia Treatment: Is There a Role for Osteopathic Manipulative Treatment

NCT01643837
View directory record Official record
Conditions
Mastalgia
Interventions
Osteopathic Manipulative Treatment, Osteopathic Manipulative Light Touch Protocol (LT)
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Central Islip, New York • Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional

The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function

NCT01854892
View directory record Official record
Conditions
Low Back Pain
Interventions
Manipulation, Mobilization, Laser Therapy
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 45 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Central Mechanisms of Intervention for Low Back Pain

NCT01406847
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Spinal Mobilization, Static Touch
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 22, 2026, 7:37 AM EDT
Not yet recruiting Not applicable Interventional

Can a Specific OMT Protocol Influence Patient Pain and Associated Analgesia Use for Primary Headache Disorders?

NCT06546462
View directory record Official record
Conditions
Headache Disorders, Headache, Analgesia, Opioid Use, Osteopathy
Interventions
Osteopathic Manipulative Treatment (OMT), Sham Light touch arm
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Sep 22, 2026, 7:37 AM EDT
Not listed Not applicable Interventional

Effects of Osteopathic Manipulative Treatment (OMT) on Gait Biomechanics in Parkinson's Disease

NCT03616145
View directory record Official record
Conditions
Parkinson Disease
Interventions
Osteopathic Manipulative Treatment (OMT), Light Touch
Procedure · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2023 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Phase 2Phase 3 Interventional

Dose of Spinal Manipulation for Chronic Low Back Pain

NCT00376350
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Light Massage, Pulsed Ultrasound
Procedure
Lead sponsor
University of Western States
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preliminary Evaluation of an Osteopathic Manipulative Treatment (OMT) to Prevent Motion Sickness Symptoms

NCT05611814
View directory record Official record
Conditions
Motion Sickness
Interventions
Osteopathic Manipulative Treatment, Sham treatment
Other
Lead sponsor
United States Army Aeromedical Research Laboratory
Federal
Eligibility
19 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Rucker, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 9, 2022 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Lumbar Manipulation for Hip and Muscle Strength

NCT03101956
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
Lumbar Spine Manipulation, Lumbar Spine Manipulation Placebo
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Osteopathic Manipulative Treatment (OMT) on Proprioception in Adults

NCT04374227
View directory record Official record
Conditions
Osteopathy in Diseases Classified Elsewhere
Interventions
Osteopathic Manipulative Treatment
Procedure
Lead sponsor
Des Moines University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment for Back Pain

NCT03892759
View directory record Official record
Conditions
Back Pain, Lumbar Pain, Thoracic Pain, Somatic Dysfunction, Fascial Distortion
Interventions
Osteopathic Manipulative Therapy
Other
Lead sponsor
Pacific Northwest University of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Yakima, Washington
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Osteopathic Manipulative Treatment and Bio Electro-Magnetic Regulation Therapy on Low Back Pain in Adults.

NCT04704375
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Bio Electro-Magnetic Regulation (BEMER) Therapy, OMT (osteopathic manipulative treatment), Light touch
Device · Procedure
Lead sponsor
Lake Erie College of Osteopathic Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manipulation Effects on Abdominal Muscles

NCT01745939
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham manipulation
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Sep 22, 2026, 7:37 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Multiple Component Mobile-aid Pain Reduction Intervention to Decrease Myofascial Pain

NCT05860205
View directory record Official record
Conditions
Myofascial Pain Syndrome
Interventions
Multiple Component Mobile-Aid Pain Reduction Intervention, Osteopathic Manipulation Treatment, Sham Osteopathic Manipulation
Behavioral · Other
Lead sponsor
Kailea Manning
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated May 15, 2023 · Synced Sep 22, 2026, 7:37 AM EDT
Withdrawn Not applicable Interventional

Dry Needling for Patients With Back Pain

NCT03586778
View directory record Official record
Conditions
Back Pain
Interventions
dry needling, manual therapy, therapeutic exercise
Other
Lead sponsor
Concord Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 22, 2026, 7:37 AM EDT
Completed Not applicable Interventional

The Effects of Thrust Joint Manipulation on the Resting and Contracting Thickness of Transversus Abdominis in Subjects With Low Back Pain

NCT02558855
View directory record Official record
Conditions
Low Back Pain
Interventions
Thrust Joint Manipulation of the Lumbar Spine, Non-thrust Joint Manipulation of the Lumbar Spine
Other
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 70 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
2
States / cities
Flagstaff, Arizona • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 11, 2016 · Synced Sep 22, 2026, 7:37 AM EDT