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Showing 1–24 of 38 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Lumbar Spine Manipulation Clear all
Withdrawn Not applicable Interventional

Dry Needling for Patients With Back Pain

NCT03586778
View directory record Official record
Conditions
Back Pain
Interventions
dry needling, manual therapy, therapeutic exercise
Other
Lead sponsor
Concord Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Phase 2 Interventional Results available

Optimization of Spinal Manipulative Therapy Protocols

NCT02868034
View directory record Official record
Conditions
Low Back Pain
Interventions
SMT, Mobilizing Exercises, Activation Exercises, SMT extended
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Phase 2Phase 3 Interventional

Dose of Spinal Manipulation for Chronic Low Back Pain

NCT00376350
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Light Massage, Pulsed Ultrasound
Procedure
Lead sponsor
University of Western States
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Using MRI Scans to Evaluate Spinal Manipulation

NCT00070902
View directory record Official record
Conditions
Lower Back Pain
Interventions
Lumbar side-posture spinal adjusting
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
21 Years to 29 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2002
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2006 · Synced Sep 4, 2026, 7:47 PM EDT
Not listed Not applicable Interventional

Effects of Osteopathic Manipulative Treatment (OMT) on Gait Biomechanics in Parkinson's Disease

NCT03616145
View directory record Official record
Conditions
Parkinson Disease
Interventions
Osteopathic Manipulative Treatment (OMT), Light Touch
Procedure · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2023 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment

NCT02848456
View directory record Official record
Conditions
Subluxation of Joint of Lumbar Spine
Interventions
Spinal Manipulation, Max Voluntary Isometric Contraction, SM+MVIC
Procedure
Lead sponsor
Grant Sanders
Other
Eligibility
20 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of the Effect of Spine Grade I and II Manipulation and a PNE Video on Brainwaves: Pilot Study

NCT04908670
View directory record Official record
Conditions
Chronic Pain, Manipulation, Psychologic
Interventions
Understanding Pain in less than 5 minutes, and what to do about it! https://www.youtube.com/watch?v=C_3phB93rvI, PA manipulation
Behavioral · Procedure
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
20 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Merrillville, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manipulation Effects on Abdominal Muscles

NCT01745939
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham manipulation
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of a Potential Mechanisms of Spinal Manipulation in the Treatment of Low Back Pain

NCT00922220
View directory record Official record
Conditions
Low Back Pain
Interventions
stationary bike, lumbar extension exercise, spinal manipulative therapy
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 21, 2011 · Synced Sep 4, 2026, 7:47 PM EDT
Recruiting Not applicable Interventional

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

NCT04142177
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Pain EASE, Tailored exercise, Continued Care and Active Monitoring, Cognitive Behavioral Therapy (CBT), Spinal Manipulation Therapy (SMT), Yoga
Other · Procedure · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
2,529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
19
States / cities
Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of OMT on Gait Kinematics and Postural Control in Parkinson Disease

NCT04946760
View directory record Official record
Conditions
Parkinson Disease
Interventions
Sham Manipulation
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
50 Years and older
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional

Feasibility Assessment of Neurophysiological Measurement in Veterans With LBP

NCT02375386
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal manipulation, Therapeutic touch, fMRI, Pain Sensitivity Testing, Questionnaires, Physical Impairment
Procedure · Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2021 · Synced Sep 4, 2026, 7:47 PM EDT
Not listed Not applicable Interventional

Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability

NCT06294132
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham Lumbar Manipulation
Procedure
Lead sponsor
Ithaca College
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional

Dry Needling and Spinal Manipulation vs. Conventional PT for Lumbar Spinal Stenosis

NCT03167736
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
electric dry needling, manipulation, conventional physical therapy
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
50 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Canton, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional

Using an Interactive Game to Reduce Fear and Increase Spine Motion in Low Back Pain

NCT02301741
View directory record Official record
Conditions
Low Back Pain
Interventions
Game
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 50 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 12, 2016 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional

Effect of Lower Back Treatment in People With Patellofemoral Pain Syndrome.

NCT01975311
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Lumbopelvic Manipulation, Passive lumbar spine flexion and extension
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Sep 4, 2026, 7:47 PM EDT
Not yet recruiting Not applicable Interventional

Can a Specific OMT Protocol Influence Patient Pain and Associated Analgesia Use for Primary Headache Disorders?

NCT06546462
View directory record Official record
Conditions
Headache Disorders, Headache, Analgesia, Opioid Use, Osteopathy
Interventions
Osteopathic Manipulative Treatment (OMT), Sham Light touch arm
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Thoraco-Lumbar Fascia Mobility

NCT03916705
View directory record Official record
Conditions
Low Back Pain
Interventions
High Velocity Low amplitude spinal manipulation (HVLA-SM)
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment for Back Pain

NCT03892759
View directory record Official record
Conditions
Back Pain, Lumbar Pain, Thoracic Pain, Somatic Dysfunction, Fascial Distortion
Interventions
Osteopathic Manipulative Therapy
Other
Lead sponsor
Pacific Northwest University of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Yakima, Washington
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 4, 2026, 7:47 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chiropractic Distraction Spinal Manipulation- Lumbar Stenosis Study

NCT03863769
View directory record Official record
Conditions
Spinal Stenosis Lumbar
Interventions
Lumbar Spinal Stenosis
Other
Lead sponsor
Parker University
Other
Eligibility
48 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional

The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function

NCT01854892
View directory record Official record
Conditions
Low Back Pain
Interventions
Manipulation, Mobilization, Laser Therapy
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 45 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional

Lumbar Manipulation for Hip and Muscle Strength

NCT03101956
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
Lumbar Spine Manipulation, Lumbar Spine Manipulation Placebo
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Sep 4, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Central Mechanisms of Intervention for Low Back Pain

NCT01406847
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Spinal Mobilization, Static Touch
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 4, 2026, 7:47 PM EDT
Withdrawn Not applicable Interventional

Mastalgia Treatment: Is There a Role for Osteopathic Manipulative Treatment

NCT01643837
View directory record Official record
Conditions
Mastalgia
Interventions
Osteopathic Manipulative Treatment, Osteopathic Manipulative Light Touch Protocol (LT)
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Central Islip, New York • Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 4, 2026, 7:47 PM EDT