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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional Results available

The Effects of Lycopene on High Risk Prostatic Tissue

NCT01443026
View directory record Official record
Conditions
Intraepithelial Prostatic Neoplasia, Prostatic Neoplasms
Interventions
Lycopene 30mg, Placebo
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
40 Years and older · Male only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Sep 3, 2026, 4:11 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Tomato Juice for Health Study

NCT03783013
View directory record Official record
Conditions
Healthy Volunteers
Interventions
High Lycopene Tomato Juice With Soy Germ Extract, Low Lycopene Tomato Juice
Other
Lead sponsor
USDA Beltsville Human Nutrition Research Center
Federal
Eligibility
30 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 2 Interventional Results available

Lycopene in Treating Patients Undergoing Radical Prostatectomy for Prostate Cancer

NCT00450749
View directory record Official record
Conditions
Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage II Prostate Cancer, Stage III Prostate Cancer
Interventions
placebo, therapeutic conventional surgery, laboratory biomarker analysis, lycopene
Other · Procedure · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 3 Interventional

Trial of Lycopene/Ateronon for Secondary Prevention of Coronary Heart Disease

NCT00939237
View directory record Official record
Conditions
Coronary Heart Disease
Interventions
Ateronon, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
50 Years and older
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2014 · Synced Sep 3, 2026, 4:11 PM EDT
Recruiting Phase 1Phase 2 Interventional

Soy Tomato Juice to Improve Outcomes in Pancreatitis

NCT07447687
View directory record Official record
Conditions
Recurrent Acute Pancreatitis, Chronic Pancreatitis
Interventions
Soy-tomato juice product, Will include a soy-tomato juice product to be consumed during the 4 week intervention phase. A total of about 12 ounces (administered in two small cans) of the juice will be consumed
Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 3, 2026, 4:11 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Carotenoid and Flavonoid Absorption From Red and Tangerine-Type Tomatoes

NCT01696773
View directory record Official record
Conditions
Carotenoid and Flavonoid Absorption
Interventions
Tangerine tomato juice, Red tomato juice
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Human Lycopene and Beta-cryptoxanthin Absorption From Citrus Fruit

NCT02348164
View directory record Official record
Conditions
Bioavailability of Carotenoids
Interventions
Pink grapefruit first followed by tangerines two weeks later, Tangerines first followed by pink grapefruit two weeks later
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2015 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Dietary Intervention in Persons With Metabolic Syndrome

NCT03836651
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Dietary Antioxidant (V8® Low Sodium 100% vegetable juice), Control group
Other
Lead sponsor
Martha Biddle
Other
Eligibility
21 Years to 90 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of LycoRed Phytonutrient and Vitamin Supplement (a.k.a. LYC-001e) on Ocular Blood Flow

NCT03068377
View directory record Official record
Conditions
Ocular Blood Flow
Interventions
Experimental, Placebo
Dietary Supplement
Lead sponsor
LycoRed Ltd.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Novel Metabolites of Beta-Carotene and Lycopene

NCT02550483
View directory record Official record
Conditions
Healthy
Interventions
Base diet + high beta-carotene tomato juice, Base diet + high lycopene tomato juice, Base diet + placebo beverage
Other
Lead sponsor
USDA Beltsville Human Nutrition Research Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Lycopene in Healthy Male Participants

NCT00450957
View directory record Official record
Conditions
Healthy, no Evidence of Disease, Prostate Cancer
Interventions
lycopene, pharmacological study
Dietary Supplement · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 55 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional

A Randomized Triple-Blind Placebo-Controlled Study to Evaluate the Effects of a Supplement on Lower Urinary Tract Symptoms in Men.

NCT06504472
View directory record Official record
Conditions
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, Erectile Dysfunction
Interventions
ProstaThrive™ Supplement, Placebo
Dietary Supplement
Lead sponsor
Optimale
Industry
Eligibility
40 Years and older · Male only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lycopene-rich Juice Intervention to Reduce Inflammatory Markers Among Adults With Obesity

NCT07120035
View directory record Official record
Conditions
Inflammatory Markers
Interventions
Lycopene-rich juice
Dietary Supplement
Lead sponsor
East Carolina University
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Tangerine or Red Tomato Juice in Treating Patients With Prostate Cancer Undergoing Surgery

NCT02144649
View directory record Official record
Conditions
Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer, Stage IV Prostate Cancer
Interventions
dietary intervention (tangerine tomato juice), dietary intervention (red tomato juice), questionnaire administration, Correlative studies
Dietary Supplement · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older · Male only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Columbus, Ohio • Dublin, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 29, 2019 · Synced Sep 3, 2026, 4:11 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effect of Lycopene and Isoflavones on Glucose Metabolism

NCT01377961
View directory record Official record
Conditions
Metabolic Syndrome, Diabetes Mellitus, Non-Insulin-Dependent
Interventions
Randomized pills either containing combination of lycopene and isoflavones (dietary supplements) or Placebo to be taken for 12 weeks, Screening, OGTT, Anthropometrics and Blood pressure, Blood Drawing
Drug · Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
2
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2015 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 2 Interventional Results available

Males, Antioxidants, and Infertility Trial

NCT02421887
View directory record Official record
Conditions
Male Infertility
Interventions
Antioxidant Supplement, Placebo
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Male only
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
10
States / cities
Los Angeles, California • San Francisco, California • Sunnyvale, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Novel 13C Carotenoids for Absorption and Metabolism Studies in Humans

NCT01692340
View directory record Official record
Conditions
Healthy
Interventions
Isotopically labeled lycopene, phytoene or phytofluene
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Processed Tomato Products on CVD Risks

NCT00937742
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Tomato products
Dietary Supplement
Lead sponsor
Penn State University
Other
Eligibility
21 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 2 Interventional

Lycopene in Treating Patients With Metastatic Prostate Cancer

NCT00068731
View directory record Official record
Conditions
Prostate Cancer
Interventions
lycopene
Dietary Supplement
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older · Male only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
18
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Atlanta, Georgia + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 1 Interventional

Lycopene In Preventing of Prostate Cancer

NCT00006078
View directory record Official record
Conditions
Prostate Cancer
Interventions
lycopene
Dietary Supplement
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 45 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 25, 2013 · Synced Sep 3, 2026, 4:11 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Acute Effects of Watermelon on Vascular Function and Serum Lycopene

NCT03608254
View directory record Official record
Conditions
Vascular Health of Postmenopausal Women
Interventions
100% watermelon juice
Other
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
65 Years to 70 Years · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 2 Interventional

Nutrition Intervention to Decrease Symptoms in Patients With Heart Failure

NCT01733017
View directory record Official record
Conditions
Heart Failure
Interventions
Sodium reduction, omega 3 and lycopene supplements, rice bran oil capsules, Generic dietary feedback from
Behavioral · Dietary Supplement
Lead sponsor
Terry Lennie
Other
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
2
States / cities
Lexington, Kentucky • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Prostate Biomarkers in Men Consuming Tomato Products

NCT02292524
View directory record Official record
Conditions
Prostate Cancer
Interventions
Commercially-available tomato food product
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 16, 2014 · Synced Sep 3, 2026, 4:11 PM EDT
Completed Phase 1 Interventional

Docetaxel and Lycopene in Metastatic Prostate Cancer

NCT01949519
View directory record Official record
Conditions
Adenocarcinoma of the Prostate
Interventions
Lycopene and Docetaxel
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Male only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Sep 3, 2026, 4:11 PM EDT