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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: MICA Clear all
Completed Phase 4 Interventional Results available

A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache

NCT05452239
View directory record Official record
Conditions
Migraine, Medication Overuse Headache
Interventions
Eptinezumab, Placebo
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
18 Years to 75 Years
Enrollment
608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
6
States / cities
Winter Haven, Florida • Marrero, Louisiana • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia

NCT01213524
View directory record Official record
Conditions
Tobacco Use Disorder, Schizophrenia
Interventions
sensorimotor replacement, 42 mg transdermal nicotine replacement, Placebo transdermal nicotine, usual brand smoking
Behavioral · Drug · Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 99 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 4 Interventional Results available

Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency

NCT00280293
View directory record Official record
Conditions
Bipolar Disorder, Cocaine Dependence
Interventions
Lamotrigine, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Sep 6, 2026, 2:55 PM EDT
Active, not recruiting Phase 1 Interventional

A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

NCT06328673
View directory record Official record
Conditions
Advanced Solid Tumor
Interventions
DM919, Pembrolizumab
Drug
Lead sponsor
D2M Biotherapeutics Inc.
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder

NCT00156715
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse, Alcohol Abuse
Interventions
Quetiapine
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
4
States / cities
Augusta, Georgia • Lebanon, New Hampshire • Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 13, 2018 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 4 Interventional Results available

Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual

NCT00498550
View directory record Official record
Conditions
Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder, Cannabis Abuse
Interventions
Clozapine, Treatment as usual
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2009
U.S. locations
4
States / cities
Los Angeles, California • Kansas City, Missouri • Manchester, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dual Diagnosis Training Trial

NCT06238258
View directory record Official record
Conditions
Training Group
Interventions
SPECTROM Training
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Not applicable Interventional

Alcohol Use Disorders in Schizophrenia

NCT00280813
View directory record Official record
Conditions
Schizophrenia, Mood Disorders, Alcohol Abuse, Alcohol Dependence
Interventions
Supportive Treatment in Addiction Recovery (STAR)
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
22 Years to 60 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
4
States / cities
Baltimore, Maryland • Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Treating Violence-Prone Substance Use Disorder Patients

NCT00700973
View directory record Official record
Conditions
Substance-related Disorders, Violence
Interventions
Interpersonal Violence Prevention Intervention, Usual care
Behavioral · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2015 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Not applicable Interventional

Re-Entry MTC for Offenders With MICA Disorders

NCT00249756
View directory record Official record
Conditions
Mental Disorders, Substance-Related Disorders
Interventions
Re-entry Modified Therapeutic Community (Re-entry MTC), Parole Supervision and Case Management
Behavioral
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
18 Years and older · Male only
Enrollment
610 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Caqon City, Colorado • Pueblo, Colorado • Sterling, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 1, 2013 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 4 Interventional Results available

Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems

NCT02504931
View directory record Official record
Conditions
PTSD, Alcohol Use Disorder
Interventions
Sertraline, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
21 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2018 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Not applicable Interventional

A Novel Person-Centered Treatment Component for Substance Use Treatment

NCT02005367
View directory record Official record
Conditions
Substance Use Disorders, Depression, Bipolar Disorder, Psychosis, Personality Disorders
Interventions
Natural Recovery-Horticulture, Natural Recovery-Art/Music
Behavioral
Lead sponsor
Hampton VA Medical Center
Federal
Eligibility
18 Years to 85 Years
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Hampton, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2013 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 2 Interventional Results available

Risperidone and Desipramine in Alcohol Use and Schizophrenia

NCT01411085
View directory record Official record
Conditions
Schizophrenia, Alcoholism, Dual Diagnosis
Interventions
Risperidone + Desipramine
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
4
States / cities
Worcester, Massachusetts • Grand Rapids, Michigan • Lebanon, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Not applicable Interventional

Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

NCT00108407
View directory record Official record
Conditions
Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
Interventions
Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2009 · Synced Sep 6, 2026, 2:55 PM EDT
Terminated Phase 4 Interventional

Alcoholism and Schizophrenia: Effects of Clozapine

NCT00169026
View directory record Official record
Conditions
Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse, Alcohol Abuse
Interventions
Clozapine versus typical (conventional) and atypical antipsychotic medications
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
19 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2018 · Synced Sep 6, 2026, 2:55 PM EDT
Active, not recruiting Not applicable Interventional

CRP and S&A for Inpatient Veterans

NCT05054738
View directory record Official record
Conditions
Alcoholism, Substance-related Disorders, Dual Diagnosis
Interventions
Combined Recovery Program, Stable & Able (S&A)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 6, 2026, 2:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Influence of Nicotine on Cognitive Function in Schizophrenic Patients With and Without Comorbid Drug Dependence

NCT01037075
View directory record Official record
Conditions
Schizophrenia, Drug Abuse/Dependency
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
2
States / cities
Baltimore, Maryland • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 2 Interventional

Clinical Trial of Abstinence-Linked Money Management

NCT00536900
View directory record Official record
Conditions
Substance Abuse
Interventions
Advisor-Teller Money Manager, FIT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 2 Interventional Results available

Dual Diagnosis Inpatients: Telephone Monitoring RCT to Improve Outcomes

NCT01135420
View directory record Official record
Conditions
Diagnosis, Dual (Psychiatry)
Interventions
Telephone Monitoring (TM) with Motivational Interviewing, Usual care
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
2
States / cities
Palo Alto, California • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 1Phase 2 Interventional

Effectiveness of Self-Help for Dually-Diagnosed Persons - 1

NCT00218582
View directory record Official record
Conditions
Dual Diagnosis, Substance-Related Disorders, Mental Disorders
Interventions
Double Trouble in Recovery, Standard psychiatric day treatment
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 64 Years
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 6, 2026, 2:55 PM EDT
Terminated Phase 4 Interventional Results available

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

NCT01662297
View directory record Official record
Conditions
Insomnia, Mental Health Disorder, Substance Use Disorder
Interventions
Quetiapine, Trazodone
Drug
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling

NCT00221975
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Divalproex, Lamotrigine, Lithium
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
16 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Sep 6, 2026, 2:55 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Cannabis and Schizophrenia: Self-Medication and Agonist Treatment

NCT00946348
View directory record Official record
Conditions
Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder, Cannabis Use Disorder
Interventions
Dronabinol, Cannabis
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 11, 2021 · Synced Sep 6, 2026, 2:55 PM EDT
Terminated Not applicable Interventional

Treating Co-Occurring Substance Use and Mental Disorders Among Jail Inmates

NCT02214667
View directory record Official record
Conditions
Co-occurring Mental and Substance Use Disorders, Crime, Criminogenic Thinking, Implementation, Adaptation
Interventions
Dual-diagnosis motivational interviewing (DDMI), Integrated group therapy (IGT), Jail and community-based behavioral health services
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Sep 6, 2026, 2:55 PM EDT