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ClinicalTrials.gov public records Last synced Oct 23, 2026, 7:05 AM EDT

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Showing 577–600 of 702 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Manipulation Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis

NCT00160784
View directory record Official record
Conditions
Adhesive Capsulitis of the Shoulder
Interventions
Arthroscopy, Arthroscopic manipulation, Home therapy
Procedure · Other
Lead sponsor
University of Florida
Other
Eligibility
20 Years to 80 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 5, 2012 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function

NCT01854892
View directory record Official record
Conditions
Low Back Pain
Interventions
Manipulation, Mobilization, Laser Therapy
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 45 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated May 12, 2017 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Mobilization Versus Manipulation for the Treatment of Cervicogenic Headaches

NCT03919630
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Thrust Mobilization, Non-Thrust Mobilizations
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Cognitive Remediation in Posttraumatic Stress Disorder (PTSD)

NCT00850447
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Remediation Therapy, Videogame
Other
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2012 · Synced Oct 23, 2026, 7:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Experimental Evaluation of Wheelchair-Mounted Robotic Arms

NCT01652352
View directory record Official record
Conditions
Spinal Cord Injury, Cerebral Palsy, Multiple Sclerosis
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2012 · Synced Oct 23, 2026, 7:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Practitioner and Instructional Set on Subject Perceptions and Expectations of Cervical Spine Manipulation

NCT03509649
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical spine manipulation
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Sacroiliac Dysfunction

NCT02373644
View directory record Official record
Conditions
Sacroiliac Joint Dysfunction
Interventions
HVLA Thrust Manipulation and DN, Conventional Physical Therapy
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Breathe: Slow Paced Breathing to Lower Blood Pressure

NCT00328016
View directory record Official record
Conditions
High Blood Pressure
Interventions
Guided Breathing, RESPeRATE
Behavioral · Device
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
40 Years to 70 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Physical Therapy Trial for Pelvic Pain

NCT00434343
View directory record Official record
Conditions
Interstitial Cystitis, Painful Bladder Syndrome, Chronic Prostatitis, Chronic Pelvic Pain Syndrome
Interventions
Global Therapeutic Massage (GTM), Myofascial physical therapy (MPT)
Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
5
States / cities
Stanford, California • Chicago, Illinois • Maywood, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Oct 23, 2026, 7:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility

NCT07217652
View directory record Official record
Conditions
Schizophrenia, Attention Deficit Disorder With Hyperactivity (ADHD)
Interventions
High-resolution fMRI during working memory, cognitive control, and decision-making tasks
Other
Lead sponsor
Kai Hwang
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 23, 2026, 7:05 AM EDT
Recruiting Not applicable Interventional

The Power Down Pilot Study: A Novel Bedtime Manipulation Protocol

NCT06386029
View directory record Official record
Conditions
Autism, Sleep Disturbance
Interventions
Power Down bedtime manipulation
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
6 Years to 10 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional Results available

Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients

NCT00830596
View directory record Official record
Conditions
Low Back Pain
Interventions
HVLA-SM, LVVA-SM, Sham Intervention
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Using fMRI to Determine if Cerebral Hemodynamic Responses to Pain Change Following Thoracic Spine Manipulation in Individuals With Mechanical Neck Pain

NCT01862705
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spine manipulation
Other
Lead sponsor
OSF Healthcare System
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Oct 23, 2026, 7:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain

NCT06818175
View directory record Official record
Conditions
Low Back Pain, Chronic Low-back Pain, Acute Low Back Pain
Interventions
Ultrsound Guided Hydrodissection of the Thoracolumbar Fascia, Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 23, 2026, 7:05 AM EDT
Recruiting Not applicable Interventional

Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care

NCT05726331
View directory record Official record
Conditions
Neck Pain, Chronic Pain
Interventions
Chiropractic Care, Tai Chi, Enhanced Usual Care
Other
Lead sponsor
Harvard University Faculty of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 19, 2024 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Phase 2 Interventional

Development of a Clinical Prediction Rule to Identify Patients With Shoulder Pain Likely to Benefit From Cervicothoracic Manipulation

NCT00835302
View directory record Official record
Conditions
Shoulder Pain
Interventions
Cervicothoracic manipulation
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
6
States / cities
Aurora, Colorado • Boulder, Colorado • Greenwood Village, Colorado + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2013 · Synced Oct 23, 2026, 7:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evolution of the Mind-body Connection While Learning About Common Osteopathic Dysfunctions

NCT05466032
View directory record Official record
Conditions
Medical School Syndrome, Mind Body Awareness
Interventions
Osteopathic Manual Manipulation (OMM) Curriculum
Other
Lead sponsor
Mikhail Volokitin, MD, DO.
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Oct 23, 2026, 7:05 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

NCT05232032
View directory record Official record
Conditions
Depressive Disorder, Major, Anxiety Disorder
Interventions
Nociceptin Receptor Antagonist, Aversive stimuli
Drug · Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 23, 2026, 7:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Anti-inflammatory Actions of Osteopathic Manipulative Treatment

NCT04177264
View directory record Official record
Conditions
Inflammation
Interventions
Occipito-Atlantal Decompression (OA DC), Sham Occipito-Atlantal Decompression (Sham OA DC), Splenic Lymphatic Pump Technique (SpLPT), Sham Splenic Lymphatic Pump Technique (Sham SpLPT), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS)
Procedure · Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 23, 2026, 7:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Satisfaction and Feasibility Evaluation of an Electronic Massager Compared to Massage Therapist-delivered Massage

NCT07042776
View directory record Official record
Conditions
Massage Therapy
Interventions
EMMA (Expert Manipulative Massage Automation), Therapist-delivered massage
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison Across Multiple Types of Sleep Deprivation

NCT04211506
View directory record Official record
Conditions
Sleep Deprivation, Sleep Restriction
Interventions
Controlled sleep
Behavioral
Lead sponsor
Civil Aerospace Medical Institute
Federal
Eligibility
20 Years to 45 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 29, 2023 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress, Sex, and the Generalization of Fear

NCT03786952
View directory record Official record
Conditions
Psychological Stress
Interventions
Stress immediately before learning in males, Sham control immediately before learning in males, Stress 30 minutes before learning in males, Sham control 30 minutes before learning in males, Stress immediately before learning in females, Sham control immediately before learning in females, Stress 30 minutes before learning in females, Sham control 30 minutes before learning in females
Behavioral
Lead sponsor
Ohio Northern University
Other
Eligibility
18 Years and older
Enrollment
606 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ada, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Central Mechanism of Manual Therapy for Low Back Pain

NCT03078114
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Placebo Spinal Manipulation
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Kansas City, Kansas • Leavenworth, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Oct 23, 2026, 7:05 AM EDT
Completed Not applicable Interventional

Is Osteopathic Manipulative Treatment (OMT) Beneficial for Elderly Patients Hospitalized With Pneumonia?

NCT00258661
View directory record Official record
Conditions
Pneumonia
Interventions
Osteopathic Manipulative Treatment, Light-touch Treatment
Procedure
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
50 Years and older
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
7
States / cities
Mount Clemens, Michigan • Kirksville, Missouri • Stratford, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2018 · Synced Oct 23, 2026, 7:05 AM EDT