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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Manipulation + Exercise Group Clear all
Not listed Early Phase 1 Interventional

Clinical Assessment of Two Manipulative Protocols in Treatment of Hip Osteoarthritis

NCT00523172
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
manual or manipulative therapy, Manual / Manipulative Therapy, Supportive Care
Procedure
Lead sponsor
Cleveland Chiropractic College
Other
Eligibility
40 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 18, 2010 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does the Addition of Manual Therapy Techniques Increase Gastrocnemius/Soleus Length More Than Stretching Alone?

NCT01856972
View directory record Official record
Conditions
Muscle Tightness
Interventions
Instrument Assisted Soft Tissue Mobilization, Rearfoot joint mobilization, Static stretching/ROM exercises
Procedure · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 10, 2014 · Synced Sep 6, 2026, 9:34 AM EDT
Not listed Not applicable Interventional

Comparison of Craniosacral Therapy vs Pelvic Floor Physical Therapy

NCT03213522
View directory record Official record
Conditions
Multiple Sclerosis, Bladder Dysfunction, Urinary Incontinence, Overactive Bladder
Interventions
Pelvic Floor Physical Therapy, Craniosacral Therapy
Procedure
Lead sponsor
CentraState Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Freehold, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Phase 2Phase 3 Interventional

Validation of a Clinical Prediction Rule to Identify Patients With Shoulder Pain Likely to Benefit From Cervicothoracic Manipulation: A Randomized Clinical Trial

NCT01571674
View directory record Official record
Conditions
Shoulder Pain
Interventions
Manipulation + Exercise Group, Exercise Group
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
9
States / cities
Aurora, Colorado • Boulder, Colorado • Concord, New Hampshire + 5 more
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional

A Comparison of Two Different Methods of Physical Therapy to Treat Acute and Subacute Low Back Pain

NCT02060617
View directory record Official record
Conditions
Low Back Pain
Interventions
Patient Education, Manual therapy of the thoracolumbosacral spine and hips, Motor control exercises, Treatment-Based Classification intervention
Behavioral · Procedure
Lead sponsor
Hendricks Regional Health
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Plainfield, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Sep 6, 2026, 9:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Multiple Component Mobile-aid Pain Reduction Intervention to Decrease Myofascial Pain

NCT05860205
View directory record Official record
Conditions
Myofascial Pain Syndrome
Interventions
Multiple Component Mobile-Aid Pain Reduction Intervention, Osteopathic Manipulation Treatment, Sham Osteopathic Manipulation
Behavioral · Other
Lead sponsor
Kailea Manning
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated May 15, 2023 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of a Personalized vs. Standard Approach to Weight Loss Recommendations

NCT04639076
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Behavioral Weight Loss Program, Personalized Behavioral Weight Loss Program
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
20 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional

Translational Manipulation Under Interscalene Block for Adhesive Capsulitis of the Shoulder (TMACS)

NCT03090555
View directory record Official record
Conditions
Shoulder Adhesive Capsulitis, Frozen Shoulder, Adhesive Capsulitis of Shoulder
Interventions
Translational manipulation, Manual therapy
Procedure
Lead sponsor
Daniel G. Rendeiro
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Sep 6, 2026, 9:34 AM EDT
Recruiting Not applicable Interventional

Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care

NCT05726331
View directory record Official record
Conditions
Neck Pain, Chronic Pain
Interventions
Chiropractic Care, Tai Chi, Enhanced Usual Care
Other
Lead sponsor
Harvard University Faculty of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo

NCT01529151
View directory record Official record
Conditions
Vertigo, Dizziness, Benign Paroxysmal Positional Vertigo, Labyrinthitis
Interventions
Osteopathic Manipulative Treatment (OMT), Vestibular Rehabilitation Therapy (VRT)
Other
Lead sponsor
Western University of Health Sciences
Other
Eligibility
18 Years to 79 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Phase 3 Interventional

Assessing Patient Response to Therapeutic Exercise Based on Clinical Prediction Rule (CPR) for Spinal Manipulation

NCT00916734
View directory record Official record
Conditions
Low Back Pain
Interventions
MDT (McKenzie Method), Spinal thrust manipulation
Procedure
Lead sponsor
Daemen College
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Amherst, New York
Source: ClinicalTrials.gov public record
Updated Dec 4, 2011 · Synced Sep 6, 2026, 9:34 AM EDT
Recruiting Not applicable Interventional

Chiropractic Care for Episodic Migraine

NCT06229834
View directory record Official record
Conditions
Episodic Migraine
Interventions
Chiropractic Care, Headache Health Education
Procedure · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional

Cancer Pain Rehabilitation Program to Reduce Pain Related Distress, and Reliance of Pain Medication Through Multimodal Nonpharmacological Solutions

NCT05036408
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Behavioral, Psychological or Informational Intervention, Educational Intervention, Manipulative and Body-Based Intervention Procedure, Occupational Therapy, Physical Activity, Physical Therapy, Questionnaire Administration
Other · Procedure · Behavioral
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional

Dry Needling for Patients With Neck Pain

NCT02731014
View directory record Official record
Conditions
Neck Pain
Interventions
Dry Needling, Sham Dry Needling, Manual Therapy, Exercise
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Indianapolis, Indiana • Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Phase 2 Interventional

Chiropractic and Exercise for Seniors With Low Back Pain

NCT00269321
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic Manual treatment + home exercise (procedure+behavior), Supervised rehabilitative exercise+home exercise, Home exercise
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
65 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 27, 2013 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional

Comparison of Usual Podiatric Care and Early Physical Therapy for Plantar Heel Pain

NCT01865734
View directory record Official record
Conditions
Fasciitis, Plantar
Interventions
Physical therapy after initial podiatry visit, Usual care provided by podiatry
Other
Lead sponsor
Des Moines University
Other
Eligibility
18 Years to 70 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 21, 2019 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional

Dry Needling for Sub Acromial Pain Syndrome

NCT03442894
View directory record Official record
Conditions
Subacromial Impingement Syndrome
Interventions
Standard Physical Therapy Treatment, Dry Needling, Sham Dry Needling
Procedure
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 65 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 6, 2026, 9:34 AM EDT
Terminated Not applicable Interventional

Risk Stratification in Primary Care Combined With Stratified-specific Physical Therapy Care for Low Back Pain

NCT03065894
View directory record Official record
Conditions
Low Back Pain
Interventions
Matched Physical Therapy Intervention, Current Care in Family Medicine
Other
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Phase 2 Interventional

Chiropractic and Exercise for Seniors With Neck Pain

NCT00269308
View directory record Official record
Conditions
Neck Pain
Interventions
Chiropractic Manual treatment + home exercise ( procedure+behavior), Supervised rehabilitative exercise + home exercise, Home exercise
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
65 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 22, 2011 · Synced Sep 6, 2026, 9:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability

NCT03428620
View directory record Official record
Conditions
Ankle Sprains
Interventions
High Velocity Low Amplitude mobilization, Exercise protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Fayetteville, North Carolina • Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Sep 6, 2026, 9:34 AM EDT
Active, not recruiting Early Phase 1 Interventional

Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain

NCT04744883
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Spinal Manipulation Therapy (SMT), Naloxone, Placebo, Mindfulness Based Stress Reduction Therapy (MT)
Other · Drug · Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 6, 2026, 9:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy

NCT04234282
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity, Knee Pain Swelling, Muscle Weakness, Muscle Weakness Condition, Power
Interventions
Manual Physical Therapy
Procedure
Lead sponsor
Jennifer Moreno Clinic
Other
Eligibility
45 Years to 74 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 6, 2026, 9:34 AM EDT
Terminated Phase 3 Interventional

Standardizing Management of Patients With Low Back Pain in Primary Care and Physical Therapy

NCT00769626
View directory record Official record
Conditions
Back Pain, Low Back Pain
Interventions
Usual Care, Early Treatment
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
3
States / cities
South Jordan, Utah • Taylorsville, Utah • West Jordan, Utah
Source: ClinicalTrials.gov public record
Updated Jul 17, 2011 · Synced Sep 6, 2026, 9:34 AM EDT
Completed Not applicable Interventional Results available

Collaborative Care for Older Adults With Back Pain (COCOA)

NCT01312233
View directory record Official record
Conditions
Low Back Pain
Interventions
Medical Care, Dual Care, Shared Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
65 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Sep 6, 2026, 9:34 AM EDT