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Showing 1–24 of 126 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Manual / Manipulative Therapy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Manual Therapy on Shoulder Function

NCT04513535
View directory record Official record
Conditions
Musculoskeletal Manipulations, Shoulder, Range of Motion, Muscle Strength, Surface Electromyography
Interventions
Thoracic Manipulation, Cervical Manipulation, glenohumeral posterior glide mobilization, Sleeper stretch
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Sep 4, 2026, 12:27 AM EDT
Withdrawn Not applicable Interventional

Dry Needling for Patients With Back Pain

NCT03586778
View directory record Official record
Conditions
Back Pain
Interventions
dry needling, manual therapy, therapeutic exercise
Other
Lead sponsor
Concord Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

Cancer Pain Rehabilitation Program to Reduce Pain Related Distress, and Reliance of Pain Medication Through Multimodal Nonpharmacological Solutions

NCT05036408
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Behavioral, Psychological or Informational Intervention, Educational Intervention, Manipulative and Body-Based Intervention Procedure, Occupational Therapy, Physical Activity, Physical Therapy, Questionnaire Administration
Other · Procedure · Behavioral
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 4, 2026, 12:27 AM EDT
Completed No phase listed Observational

Asthma and Osteopathic Manipulative Treatment

NCT03864354
View directory record Official record
Conditions
Asthma
Interventions
Osteopathic Manipulative Treatment
Procedure
Lead sponsor
Des Moines University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Sep 4, 2026, 12:27 AM EDT
Not listed Not applicable Interventional

Study Evaluating the Benefit of Dry Needling for Patients With Neck Pain

NCT01301170
View directory record Official record
Conditions
Neck Pain
Interventions
dry needling
Procedure
Lead sponsor
Integrated Therapy Practice PC
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Hobart, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 22, 2011 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Phase 1Phase 2 Interventional

Ankle Sprains and Corticospinal Excitability

NCT00847769
View directory record Official record
Conditions
Ankle Sprain
Interventions
High velocity, low amplitude stretch, Slow, mobilization stretch, Passive Positioning
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 4, 2026, 12:27 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy

NCT04234282
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity, Knee Pain Swelling, Muscle Weakness, Muscle Weakness Condition, Power
Interventions
Manual Physical Therapy
Procedure
Lead sponsor
Jennifer Moreno Clinic
Other
Eligibility
45 Years to 74 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

iEAT 2.0 Open Trial

NCT03383029
View directory record Official record
Conditions
Gastrointestinal Disorders
Interventions
iEAT Program
Behavioral
Lead sponsor
Emory University
Other
Eligibility
12 Months to 6 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Phase 2Phase 3 Interventional

Chiropractic and Exercise for Low Back Pain in Adolescents

NCT01096628
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic + Exercise, Exercise
Other
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
12 Years to 18 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Bloomington, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 30, 2014 · Synced Sep 4, 2026, 12:27 AM EDT
Not listed Not applicable Interventional

Korean Medicine for Symptomatic Lumbar Spinal Spondylolisthesis

NCT03107468
View directory record Official record
Conditions
Spondylolisthesis, Lumbosacral Region
Interventions
Mokhuri intensive treatment, Non-surgical conventional standard treatment
Other
Lead sponsor
Kim Ki Ok
Other
Eligibility
19 Years to 78 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

Short-Term Effects of Combined Manual Therapy to the Cervical and Thoracic Spine

NCT01318720
View directory record Official record
Conditions
Neck Pain
Interventions
Manual Therapy
Other
Lead sponsor
Masefield and Cavallaro Physical Therapy
Other
Eligibility
18 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 4, 2026, 12:27 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Quantitative Ultrasound Biomarkers to Assess Upper Trapezius Muscles in Patients With Chronic Pain

NCT05497622
View directory record Official record
Conditions
Chronic Neck Pain
Interventions
Quantitative Ultrasound, Osteopathic TART Assessment, Osteopathic Manipulation Treatment
Diagnostic Test · Procedure
Lead sponsor
Rocky Vista University, LLC
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Ivins, Utah
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Sep 4, 2026, 12:27 AM EDT
Not listed Not applicable Interventional

Manual and Manipulative Therapy for Low Back Pain

NCT00632060
View directory record Official record
Conditions
Low Back Pain
Interventions
Manual / Manipulative Therapy (M/MT)
Procedure
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2008 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

Lumbar Manipulation and Exercise for the Treatment of Acute Low Back Pain in Adolescents

NCT02111278
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham Manipulation, Physical Therapy
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
13 Years to 17 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
3
States / cities
Columbus, Ohio • Westerville, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

Specific and Shared Mechanisms Associated With Treatment for Chronic Neck Pain

NCT05940012
View directory record Official record
Conditions
Chronic Neck Pain
Interventions
Manual Therapy
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Manipulation, Exercise, and Self-Care for Low Back Pain

NCT00269347
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic Spinal Manipulation, Exercise, Self-care
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 22, 2005 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does the Addition of Manual Therapy Techniques Increase Gastrocnemius/Soleus Length More Than Stretching Alone?

NCT01856972
View directory record Official record
Conditions
Muscle Tightness
Interventions
Instrument Assisted Soft Tissue Mobilization, Rearfoot joint mobilization, Static stretching/ROM exercises
Procedure · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 10, 2014 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Recovery From Plantar Heel Pain Using the Fascial Distortion Model a Pilot Study

NCT04571073
View directory record Official record
Conditions
Plantar Fasciitis of Both Feet
Interventions
Fascial Distortion Model
Procedure
Lead sponsor
Eisenhower Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Fort Gordon, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

Central Mechanism of Manual Therapy for Low Back Pain

NCT03078114
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Placebo Spinal Manipulation
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Kansas City, Kansas • Leavenworth, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2017 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient Perceptions Following a Single Session of Simulated or Genuine HVLA Manual Chiropractic Adjustments

NCT06153290
View directory record Official record
Conditions
Subluxation
Interventions
Chiropractic adjustment, Sham adjustment
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional

The Use of Manual Therapy to Treat Low-Back and Hip Pain

NCT00410397
View directory record Official record
Conditions
Low Back Pain, Pain
Interventions
Osteopathic Manipulative Medicine, Sham Manipulation
Procedure
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 14, 2008 · Synced Sep 4, 2026, 12:27 AM EDT
Terminated Not applicable Interventional

OMT of Somatic Dysfunction and Chronic Low Back Pain in Patients With Type 2 Diabetes Mellitus

NCT02054650
View directory record Official record
Conditions
Chronic Low Back Pain, Type 2 Diabetes Mellitus
Interventions
Osteopathic Manual Treatment (OMT), Sham OMT
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
18 Years to 79 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional Results available

Physical Therapy Versus Steroid Injection for Shoulder Impingement Syndrome

NCT01190891
View directory record Official record
Conditions
Shoulder Impingement Syndrome
Interventions
Manual Physical Therapy, Corticosteroid Injection
Procedure
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Apr 28, 2016 · Synced Sep 4, 2026, 12:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Lower Extremity Joint Manipulation on a Lower Extremity Somatosensory Illusion

NCT05226715
View directory record Official record
Conditions
Coordination and Balance Disturbances, Healthy
Interventions
chiropractic manual therapy
Other
Lead sponsor
Parker University
Other
Eligibility
18 Years to 35 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2022 · Synced Sep 4, 2026, 12:27 AM EDT