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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Manual / Manipulative Therapy Clear all
Completed Not applicable Interventional

Subacute Effects of Spinal Mobilization to Treat Subacromial Impingement

NCT01753271
View directory record Official record
Conditions
Subacromial Impingement Syndrome
Interventions
thoracic mobilization & shoulder mobilization & exercise, shoulder mobilization & exercise
Other
Lead sponsor
High Point University
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
3
States / cities
Chicago, Illinois • Elizabethton, Tennessee • Johnson City, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 19, 2015 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Cervical and Upper Thoracic Mobilization and Manipulation for Mechanical Neck Pain

NCT02036905
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical and thoracic mobilization, cervical and thoracic manipulation
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Solon, Ohio • Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Manual Therapy and Exercise in Patients With Cervicogenic Headache

NCT01580280
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Thrust Manipulation, Non-thrust Mobilization and Exercise
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 13, 2014 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Effect of Osteopathic Manipulative Medicine on Parkinson Disease

NCT02107638
View directory record Official record
Conditions
Parkinson Disease
Interventions
OMM treatment arm, Counseling
Procedure · Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
40 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 26, 2026, 10:55 AM EDT
Not yet recruiting Not applicable Interventional

Magnetic Resonance Elastography Of Chronic Low Back Pain Before And After Therapy

NCT07712458
View directory record Official record
Conditions
Low Back Pain, Recurrent, Chronic Low Back Pain (CLBP)
Interventions
EMMA (Expert Manipulative Massage Automation)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 26, 2026, 10:55 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Will a Hands on Technique Applied to the Face Increase the Tear Production in Participants

NCT07632183
View directory record Official record
Conditions
Increased Production of Tears
Interventions
sphenopalatine ganglion release
Procedure
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Non-Specific Effects of Manual Therapy

NCT03017534
View directory record Official record
Conditions
Musculoskeletal Manipulations, Placebo Effect
Interventions
Spinal Manual Therapy
Procedure
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 8, 2017 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manual Therapy and Augmented Exercise for Neck Pain

NCT01750736
View directory record Official record
Conditions
Neck Pain
Interventions
Augmented Exercise and Manual Therapy, General Exercise and Manual Therapy
Other
Lead sponsor
Des Moines University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
3
States / cities
Des Moines, Iowa • North Canton, Ohio • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 11, 2015 · Synced Sep 26, 2026, 10:55 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment and Migraine Headaches

NCT04976985
View directory record Official record
Conditions
Chronic Migraine, Migraine Disorders, Headache Disorders, Headache, Migraine
Interventions
Osteopathic Manipulative Therapy (OMT), Standard of care
Procedure · Other
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 50 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects

NCT01864642
View directory record Official record
Conditions
Ocular Hypertension, Glaucoma
Interventions
osteopathic manipulative treatment (OMT)
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 90 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 17, 2014 · Synced Sep 26, 2026, 10:55 AM EDT
Recruiting Phase 2Phase 3 Interventional

Comparing Adjuvant Treatments for High Tone Pelvic Floor Dysfunction

NCT07404397
View directory record Official record
Conditions
High Tone Pelvic Floor Dysfunction
Interventions
Cyclobenzaprine, Pelvic floor massage wand, Pelvic floor physical therapy
Drug · Device · Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 26, 2026, 10:55 AM EDT
Active, not recruiting Phase 2 Interventional

Integrative Medicine for Pain in Patients With Advanced Cancer Trial (IMPACT)

NCT04095234
View directory record Official record
Conditions
Cancer Pain
Interventions
Acupuncture, Massage
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
8
States / cities
Miami, Florida • Basking Ridge, New Jersey • Middletown, New Jersey + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 26, 2026, 10:55 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment for Pitch Performance in Baseball Players: A Study on Shoulder and Hip Interventions

NCT07216300
View directory record Official record
Conditions
Pitch, Baseball Pitcher, Throwing Performance
Interventions
Osteopathic Manipulative Treatment
Procedure
Lead sponsor
William Carey University
Other
Eligibility
18 Years to 102 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Hattiesburg, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Manual Medicine or Cognitive Behavioral Therapy With Chronic Uncontrolled Diabetes

NCT02971865
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
CBT/CMT, Control group traditional primary care
Behavioral · Other
Lead sponsor
Community Wellness Center, West Linn, OR
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
West Linn, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 22, 2016 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cervical Spine Manipulation Affects on Balance and Proprioception

NCT01745705
View directory record Official record
Conditions
Neck Pain, Headache
Interventions
Cervical Spine Manipulation, Manual Contact
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Physical Therapy Intervention for Extended Physical Symptoms After a Sports-related Concussion

NCT02344446
View directory record Official record
Conditions
Concussion, Dizziness
Interventions
Skilled Therapy
Other
Lead sponsor
Walsh University
Other
Eligibility
10 Years to 23 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
North Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2016 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Phase 2Phase 3 Interventional

Enhancing the Effectiveness of Physical Therapy for People With Knee Osteoarthritis

NCT01314183
View directory record Official record
Conditions
Osteoarthritis
Interventions
Exercise, manual therapy
Other
Lead sponsor
Agency for Healthcare Research and Quality (AHRQ)
Federal
Eligibility
40 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania • San Antonio, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 22, 2015 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Thoracic Manipulation on Hip Adductor, Extensor, and Latissimus Dorsi Force in Those With Adductor Weakness

NCT06534931
View directory record Official record
Conditions
Muscle Weakness
Interventions
High velocity low amplitude thoracic spine manipulation, Sham
Procedure
Lead sponsor
University of New England
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Sep 26, 2026, 10:55 AM EDT
Not listed Phase 2Phase 3 Interventional

Manual Therapy in Addition to Pulmonary Rehabilitation in Moderate Chronic Obstructive Pulmonary Disease.

NCT04386590
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease Moderate
Interventions
Manual Therapy Plus Pulmonary Rehabilitation, Sham Intervention
Other
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
50 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 26, 2026, 10:55 AM EDT
Not listed Not applicable Interventional

Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure

NCT02233140
View directory record Official record
Conditions
Diabetes, Equinus Contracture of the Ankle
Interventions
Extra-corporeal pulsed-activated therapy or shockwave therapy
Device
Lead sponsor
Temple University
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Cancer Pain Rehabilitation Program to Reduce Pain Related Distress, and Reliance of Pain Medication Through Multimodal Nonpharmacological Solutions

NCT05036408
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Behavioral, Psychological or Informational Intervention, Educational Intervention, Manipulative and Body-Based Intervention Procedure, Occupational Therapy, Physical Activity, Physical Therapy, Questionnaire Administration
Other · Procedure · Behavioral
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 26, 2026, 10:55 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Quantitative Ultrasound Biomarkers to Assess Upper Trapezius Muscles in Patients With Chronic Pain

NCT05497622
View directory record Official record
Conditions
Chronic Neck Pain
Interventions
Quantitative Ultrasound, Osteopathic TART Assessment, Osteopathic Manipulation Treatment
Diagnostic Test · Procedure
Lead sponsor
Rocky Vista University, LLC
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Ivins, Utah
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Sep 26, 2026, 10:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Immediate Neuromuscular Responses of the Obliquus Capitis Inferior Following Upper Cervical Manual Therapy

NCT07725198
View directory record Official record
Conditions
Head and Neck, Headache
Interventions
Thrust long-axis manipulation of C1-C2
Other
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Fort Myers, Florida
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 26, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Effect of Osteopathic Manipulative Medicine on Motor Function and Quality of Life in Cervical Dystonia

NCT02420106
View directory record Official record
Conditions
Cervical Dystonia
Interventions
Osteopathic Manipulative Medicine
Procedure
Lead sponsor
New York Institute of Technology
Other
Eligibility
2 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 26, 2026, 10:55 AM EDT