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Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Meal Replacement Therapy Clear all
Active, not recruiting Not applicable Interventional

Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD

NCT04861571
View directory record Official record
Conditions
NAFLD
Interventions
Dietary intervention with very low calorie diet (VLCD), Control Arm
Dietary Supplement · Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Completed No phase listed Observational

Johns Hopkins Weight Management Center Patient Data

NCT03321565
View directory record Official record
Conditions
Obesity
Interventions
Behavioral counseling and optional meal replacement program
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1990 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Weight Loss With Meal-Replacement Therapy in Teens

NCT03137433
View directory record Official record
Conditions
Obesity, Severe, Pediatric Obesity
Interventions
Meal-replacement Therapy
Dietary Supplement
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 17 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2024 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Phase 2 Interventional Results available

Safety/Efficacy of Everolimus in Adults With Advanced Pancreatic Neuroendocrine Cancer Not Responsive to Chemotherapy

NCT00363051
View directory record Official record
Conditions
Islet Cell Carcinoma, Neuroendocrine Carcinoma, Neuroendocrine Tumor, Pancreatic Neoplasms
Interventions
Everolimus 10 mg, Octreotide Depot
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
20
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 15 more
Source: ClinicalTrials.gov public record
Updated May 9, 2013 · Synced Sep 3, 2026, 9:38 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer

NCT02985801
View directory record Official record
Conditions
Pancreatic Insufficiency, Pancreatic Cancer, Pancreatic Enzyme Abnormality
Interventions
Pancrelipase, Placebo Oral Capsule
Drug
Lead sponsor
Massimo Raimondo, M.D.
Other
Eligibility
18 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 14, 2021 · Synced Sep 3, 2026, 9:38 AM EDT
Terminated Phase 4 Interventional Results available

LOSS- Louisiana Obese Subjects Study

NCT00115063
View directory record Official record
Conditions
Obesity
Interventions
group sessions, sibutramine, orlistat, diethylpropion, Low Calorie Diet, Health One, Intensive Medical Combination Therapy for Obesity, Control Condition
Behavioral · Drug · Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 60 Years
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 21, 2016 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional

The Peds Obesity Study

NCT02353637
View directory record Official record
Conditions
Pediatric Obesity
Interventions
Partial Meal Replacements
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
12 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Phase 2Phase 3 Interventional

Improving Diabetes Through Lifestyle and Surgery

NCT01667783
View directory record Official record
Conditions
Obesity, Type 2 Diabetes
Interventions
Gastric Banding, Medical Weight Loss, Gastric Bypass
Procedure · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 11, 2024 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

DASH Diet Intervention at Senior Centers

NCT03993808
View directory record Official record
Conditions
Hypertension
Interventions
Revision of congregate meal menus and recipes to align with parameters of DASH eating plan, On-site blood pressure monitoring, Home self blood pressure monitoring, Medical adherence education, Nutrition Education
Behavioral
Lead sponsor
Rockefeller University
Other
Eligibility
60 Years to 105 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Sep 3, 2026, 9:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

NCT06129110
View directory record Official record
Conditions
Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity, Insulin Resistance
Interventions
Diet Weight Loss
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Terminated Not applicable Interventional

Surgical vs. Lifestyle in Obese Older Adults

NCT03137329
View directory record Official record
Conditions
Obesity
Interventions
Exercise program, Nutrition, WLS
Behavioral · Dietary Supplement · Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
55 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional

Calorie Restriction and Brain Function in Mild Cognitive Impairment

NCT03872375
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Meal-Replacement Therapy, Dietary Counseling
Dietary Supplement · Behavioral
Lead sponsor
Iowa State University
Other
Eligibility
70 Years to 85 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Ames, Iowa • Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 3, 2026, 9:38 AM EDT
Recruiting Not applicable Interventional

Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

NCT06736028
View directory record Official record
Conditions
Obesity
Interventions
Diet Therapy, Calorie Restriction, Behavioral Support
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Active, not recruiting Phase 2 Interventional Results available

Pancreaze (Pancrelipase) for Patients With Pancreatic Adenocarcinoma With Cachexia and Exocrine Pancreatic Insufficiency

NCT04098237
View directory record Official record
Conditions
Pancreatic Adenocarcinoma
Interventions
Pancrelipase
Drug
Lead sponsor
Andrew Hendifar, MD
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional

The Effect of 3 Different Models of MNT on DM Control in Overweight Patients With T2DM

NCT02520050
View directory record Official record
Conditions
Type 2 Diabetes, Obesity
Interventions
Traditional MNT, Structured MNT, Structured MNT plus Weekly Support
Behavioral
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
30 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional

M-POWER Feasibility Study

NCT05921565
View directory record Official record
Conditions
Weight Reduction, Adherence, Patient
Interventions
Interventional Behavioral Arm
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 84 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Sep 3, 2026, 9:38 AM EDT
Recruiting Phase 2 Interventional

Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

NCT07123155
View directory record Official record
Conditions
Pompe Disease
Interventions
S-606001, Placebo
Drug
Lead sponsor
Shionogi
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
9
States / cities
Irvine, California • Gainesville, Florida • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Influence of Exercise, Weight Loss, and Exercise Plus Weight Loss on Sleep Apnea

NCT02721251
View directory record Official record
Conditions
Obstructive Sleep Apnea, Overweight
Interventions
Exercise, Weight Loss, Exercise + Weight Loss
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Sep 3, 2026, 9:38 AM EDT
Recruiting Phase 4 Interventional

Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

NCT06477159
View directory record Official record
Conditions
Exocrine Pancreatic Insufficiency
Interventions
Pancrelipase Capsules
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Los Angeles, California • Chicago, Illinois • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Recruiting No phase listed Observational

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

NCT05799222
View directory record Official record
Conditions
Overweight, PreDiabetes, Diabetes Type 2, Obesity
Interventions
Bariatrix Meal Replacement Products
Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 3, 2026, 9:38 AM EDT
Active, not recruiting Not applicable Interventional

Pea Protein Oral Nutrition Supplement for the Reduction of Gastrostomy Tube Placement Rate in Patients With Locally Advanced Head and Neck Cancer Undergoing Chemoradiation Therapy

NCT05115760
View directory record Official record
Conditions
Locally Advanced Head and Neck Carcinoma
Interventions
Dietary Supplement, Quality-of-Life Assessment, Questionnaire Administration
Dietary Supplement · Other
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Recruiting Not applicable Interventional

SMARTer Weight Loss Management

NCT05861973
View directory record Official record
Conditions
Obesity
Interventions
Adaptive SMARTer intervention (SMARTer), Diabetes Prevention Program (DPP), Self-Guided Treatment (Self-Guided)
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
492 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

fMRI and Appetite-Related Hormones Pre and Post Obesity Surgery

NCT01583725
View directory record Official record
Conditions
Obesity
Interventions
Liquid meal responses, fMRI responses to food-cues
Procedure · Behavioral
Lead sponsor
New York Obesity and Nutrition Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 3, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of Very Low Calorie Diet in Obese General Surgery Patients

NCT03553849
View directory record Official record
Conditions
Morbid Obesity
Interventions
Very low calorie diet
Dietary Supplement
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 65 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 3, 2026, 9:38 AM EDT