Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Nov 3, 2026, 1:24 PM EST

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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Conditions
Obsessive Compulsive Disorder
Interventions
Medtronic Percept Deep Brain Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
2
States / cities
Charlestown, Massachusetts • Minneapolis, Minnesota
Conditions
Tourette Syndrome
Interventions
Medtronic Activa Deep Brain Stimulation System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
15 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Not applicable Interventional Results available

Chronic Effects of DBS in Parkinson's Disease and Dystonia

NCT01934296
Conditions
Parkinson's Disease, Isolated Dystonia
Interventions
Activa PC+S
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
San Francisco, California
Conditions
Parkinson Disease
Interventions
Nighttime Deep Brain Stimulation with Varying Amplitude Settings
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Parkinson Disease
Interventions
Forced and voluntary exercise
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Completed Not applicable Interventional Results available

ADvance DBS-f in Patients With Mild Probable Alzheimer's Disease

NCT01608061
Conditions
Alzheimer Disease
Interventions
DBS-f on, DBS-f off
Device
Lead sponsor
Functional Neuromodulation Ltd
Industry
Eligibility
45 Years to 85 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • Sun City, Arizona • Gainesville, Florida + 3 more
Conditions
Parkinson Disease
Interventions
Implantable pulse generator (deep brain stimulator)
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
20 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Parkinson Disease, Parkinson
Interventions
Medtronic RC+S DBS system
Device
Lead sponsor
University of Minnesota
Other
Eligibility
45 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Treatment Resistant Depression
Interventions
Medtronic Activa PC+S System
Device
Lead sponsor
Emory University
Other
Eligibility
25 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Conditions
Parkinson's Disease
Interventions
Medtronic DBS system
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
La Jolla, California • Kansas City, Kansas
Conditions
Essential Tremor, Parkinson's Disease
Interventions
Deep brain stimulation implantation surgery, Ad-Tech Medical Instrumentation Corp. electrodes/subdural strips, FHC Guideline 4000+ system and/or Medtronic RC+S
Procedure · Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Epilepsy; Seizure
Interventions
Phase 1-Validation of thalamus seizure detection with concurrent video EEG monitoring, Phase 2-DBS Stimulation with Medtronic Percept DBS device-Out Patient
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Completed No phase listed Observational Results available

IPG Replacement Study (PREFERENCE-H)

NCT02963259
Conditions
Parkinson Disease
Interventions
SJM Infinity™ DBS IPG or SJM Brio™ DBS IPG system
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 74 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
3
States / cities
Kendall, Florida • Miami, Florida • Albany, New York
Conditions
Parkinson's Disease
Interventions
Medtronic Activa PC+S System with Chronic Neural Recording, Effort-Reward Decision-Making Task, Prefrontal Cortex Stimulation, Tablet-Based Mood Tracking (Immediate Mood Scaler)
Device · Behavioral · Other
Lead sponsor
Simon J. Little, MBBS, PhD
Other
Eligibility
30 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
San Francisco, California
Conditions
Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6
Interventions
Deep Brain Stimulation (DBS)
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
2
States / cities
San Francisco, California
Conditions
Pain, Autonomic Dysreflexia
Interventions
Deep Brain Stimulation
Device
Lead sponsor
Jonathan Jagid
Other
Eligibility
22 Years to 60 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Miami, Florida
Conditions
Obsessive-Compulsive Disorder
Interventions
Medtronic Activa Deep Brain Stimulation
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Active, not recruiting Phase 1Phase 2 Interventional

Deep Brain Stimulation Surgery for Focal Hand Dystonia

NCT02911103
Conditions
Dystonia, Focal Dystonia, Musician's Dystonia
Interventions
DBS surgery, Medtronic Activa Rechargeable System
Procedure · Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
22 Years to 100 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Treatment Resistant Disorders
Interventions
Medtronic Percept with SensSight Deep Brain Stimulation System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
22 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
TBI (Traumatic Brain Injury)
Interventions
Deep brain stimulation
Device
Lead sponsor
Jaimie M. Henderson
Other
Eligibility
22 Years to 60 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Stanford, California
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)

NCT03457675
Conditions
Obsessive-Compulsive Disorder
Interventions
Activa PC+S DBS implant for OCD, One Month Blinded Discontinuation Period
Device · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 70 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania • Providence, Rhode Island • Houston, Texas
Conditions
Parkinson Disease
Interventions
aDBS
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Conditions
Epilepsy
Interventions
Activa™ PC and Percept™ PC Neurostimulation Systems
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
7
States / cities
Los Angeles, California • San Francisco, California • Atlanta, Georgia + 4 more
Completed Not applicable Interventional Results available

Tourette Syndrome Deep Brain Stimulation

NCT02056873
Conditions
Tourette Syndrome
Interventions
Continuous DBS, Responsive Brain Stimulation (RBS Setting)
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Gainesville, Florida