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Showing 1–24 of 201 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Melatonin Clear all
Active, not recruiting Phase 2 Interventional Results available

Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer

NCT01628029
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Sleep Disorder
Interventions
Counseling, Methylphenidate Hydrochloride, Phototherapy, Placebo Administration, Quality-of-Life Assessment, Sham Intervention, Therapeutic Melatonin
Other · Drug · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia

NCT00507546
View directory record Official record
Conditions
Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced Jun 7, 2026, 10:42 AM EDT
Recruiting Not applicable Interventional

PICU-related Sleep and Circadian Dysregulation Pilot Study

NCT06505447
View directory record Official record
Conditions
Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
Interventions
Daytime light exposure, Daytime restricted feeding
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
3 Years to 6 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Jun 7, 2026, 10:42 AM EDT
Not listed Phase 4 Interventional

Effect of Rozerem on Sleep Among People With Traumatic Brain Injury

NCT01207050
View directory record Official record
Conditions
Insomnia, Brain Injury
Interventions
Ramelteon, Placebo
Drug · Dietary Supplement
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 8, 2014 · Synced Jun 7, 2026, 10:42 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Melatonin Studies of Totally Blind Children

NCT00795236
View directory record Official record
Conditions
Sleep Disorder, Blindness
Interventions
Melatonin
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
5 Years to 20 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep/Wake Cycle and Depression: An Imaging and Treatment Study

NCT04350567
View directory record Official record
Conditions
Depression; Major Depressive Disorder
Interventions
Sleep Deprivation
Other
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 100 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional

Improving Sleep in the Neurology In-Patient Population

NCT06094699
View directory record Official record
Conditions
Sleep
Interventions
Sleep friendly order set, Patient sleep menu
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Phase 2 Interventional Results available

Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin

NCT04932096
View directory record Official record
Conditions
Traumatic Brain Injury, Critical Illness, Sleep
Interventions
melatonin, placebo
Drug · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
6 Years to 18 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Circadian OS Technology on Melatonin Suppression

NCT07095270
View directory record Official record
Conditions
Circadian Disruption
Interventions
Circadian OS software
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
30 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep

NCT01586039
View directory record Official record
Conditions
Non-visual Photoreception
Interventions
Visible light
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2021 · Synced Jun 7, 2026, 10:42 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers

NCT00001546
View directory record Official record
Conditions
Sleep Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1996 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 7, 2026, 10:42 AM EDT
Recruiting Phase 2 Interventional

Clinical Trial on Agitation in Alzheimer's Dementia

NCT05543681
View directory record Official record
Conditions
Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS, Aggression
Interventions
IGC-AD1-Active, IGC-AD1-Placebo
Drug
Lead sponsor
IGC Pharma, LLC
Industry
Eligibility
60 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
23
States / cities
Maitland, Florida • Melbourne, Florida • Miami, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Results available

Bright Light Treatment At Home To Manage Chronic Pain In U.S. Veterans

NCT02373189
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Bright light
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study to Assess a Dietary Supplement on Sleep Health and Quality

NCT05368909
View directory record Official record
Conditions
Sleep Quality, Sleep Health
Interventions
Sleep Supplement, Placebo
Dietary Supplement
Lead sponsor
4Life Research, LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sandy City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 11, 2022 · Synced Jun 7, 2026, 10:42 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Melatonin and Salt on Blood Vessel Function

NCT04325191
View directory record Official record
Conditions
Cardiovascular Risk Factor
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 45 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Jun 7, 2026, 10:42 AM EDT
Recruiting Not applicable Interventional

Melatonin Adolescent Research Study

NCT04588233
View directory record Official record
Conditions
Sleep Disorders in Children
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
13 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study to Compare the Effect of an Oral Rehydration Solution on the Rate of Absorption of Functional Ingredients

NCT06524674
View directory record Official record
Conditions
Absorption, Pharmacokinetic
Interventions
Hydration Multiplier + Energy, Hydration Multiplier + Sleep, Energy Comp, Sleep Comp
Dietary Supplement · Other
Lead sponsor
Liquid I.V.
Other
Eligibility
18 Years to 55 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Raritan, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jun 7, 2026, 10:42 AM EDT
Terminated Phase 2 Interventional

Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

NCT01598259
View directory record Official record
Conditions
Burns
Interventions
Melatonin, placebo
Drug · Other
Lead sponsor
Shriners Hospitals for Children
Other
Eligibility
5 Years to 22 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 27, 2016 · Synced Jun 7, 2026, 10:42 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mechanistic Effect of Walnut Consumption on Sleep Quality

NCT06430086
View directory record Official record
Conditions
Poor Sleep Quality
Interventions
Walnut consumption, HCHS consumption
Other
Lead sponsor
Columbia University
Other
Eligibility
45 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jun 7, 2026, 10:42 AM EDT
Completed No phase listed Observational

Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU

NCT03313115
View directory record Official record
Conditions
Sleep Deprivation, Delirium
Interventions
Sleep/Wake Protocol
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
685 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

NCT03464084
View directory record Official record
Conditions
Glucose, Circadian Rhythm, Melatonin, Genes, Light
Interventions
placebo, melatonin, bright light, dim light
Drug · Dietary Supplement · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Phase 4 Interventional Results available

Total Joint Arthroplasty and Sleep

NCT03968939
View directory record Official record
Conditions
Primary Total Hip Arthroplasty, Primary Total Knee Arthroplasty
Interventions
Diphenhydramine (Benadryl), Melatonin, Sleep Hygiene Education
Drug · Dietary Supplement · Behavioral
Lead sponsor
James A. Keeney
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Jun 7, 2026, 10:42 AM EDT
Completed Phase 1Phase 2 Interventional

Melatonin and Sleep in Preventing Delirium in the Hospital

NCT02597231
View directory record Official record
Conditions
Delirium
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Scripps Health
Other
Eligibility
65 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Jun 7, 2026, 10:42 AM EDT
Recruiting Early Phase 1 Interventional

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

NCT02621944
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Melatonin, Magnetic Resonance Imaging, Pharmacokinetics, Neurological Outcome Assessment
Drug · Other · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
Up to 6 Hours
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
2
States / cities
Gainesville, Florida • Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Jun 7, 2026, 10:42 AM EDT