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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Menthol-flavored e-cigarette Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Studying the Impacts of Higher Taxes and Bans on Electronic Cigarettes to Improve Public Health

NCT07581041
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Discrete Choice Study, Survey Administration
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
15 Years and older
Enrollment
3,400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers

NCT04620616
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 59 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Cypress, California • Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 18, 2021 · Synced Sep 25, 2026, 9:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

NCT02730676
View directory record Official record
Conditions
Smoking
Interventions
Electronic Cigarette #1, Electronic Cigarette #2
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use

NCT03402243
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 9, 2021 · Synced Sep 25, 2026, 9:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

The Interaction of Flavor With Nicotine Form in Adult Smokers

NCT04262817
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine form, E-cigarette experimental flavor
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes

NCT03164668
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
menthol flavored e-cigarette, tobacco flavored e-cigarette
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Results available

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

NCT05932693
View directory record Official record
Conditions
E-Cig Use
Interventions
E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), E-liquid coolant (WS-3, 0.5%), E-liquid coolant (WS-3, 1.0%), E-liquid coolant (WS-3, 2.0%), E-liquid coolant (menthol, 0.05%), E-liquid coolant (menthol, 0.1%), E-liquid coolant (menthol, 0.5%), E-liquid coolant (menthol, 1.0%), E-liquid coolant (menthol, 2.0%), E-liquid coolant (WS-23, 0.05%), E-liquid coolant (WS-23, 0.1%), E-liquid coolant (WS-23, 0.5%), E-liquid coolant (WS-23, 1.0%), E-liquid coolant (WS-23, 2.0%), E-liquid coolant (WS-23, 4.0%)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

NCT05134415
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

NCT05294497
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product N, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Lexington, Kentucky • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

Potential Impact of Menthol Ban in Cigarettes and E-cigarettes

NCT05259566
View directory record Official record
Conditions
Tobacco Smoking
Interventions
menthol ban in cigarettes only, total menthol ban
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

NCT04708106
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Moment Study: Mixed Method E-cigarette Study

NCT02261363
View directory record Official record
Conditions
Smoking
Interventions
Ecig group 1
Other
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Phase 1 Interventional Results available

Effects of E-cigarette Flavors on Youth TCORS 2.0

NCT03634839
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Flavoring Agents, Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 8, 2024 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

NCT05023096
View directory record Official record
Conditions
Electronic Nicotine Delivery System Flavors
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

NCT05896033
View directory record Official record
Conditions
Smoking Prevention and Control
Interventions
Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes, Menthol Flavored E-cigarettes
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by Smokers

NCT04640285
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Usual Brand Cigarette, Nicorette White Ice Mint nicotine polacrilex gum
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 59 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

NCT03168191
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, Experimental Flavor, Menthol Flavor
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Sep 25, 2026, 9:12 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Experimental Tobacco Marketplace in Regulating Flavored Tobacco Products in Menthol Cigarette Smokers

NCT03897530
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking Cessation Intervention, Functional Assessment, Questionnaire Administration
Behavioral · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes

NCT03277495
View directory record Official record
Conditions
Tobacco Use
Interventions
Brief behavioral counseling
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

NCT04123041
View directory record Official record
Conditions
Electronic Cigarette Use, Tobacco Smoking
Interventions
JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
Kansas City, Kansas • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effects of Menthol in E-cigarettes on Smoking Behaviors

NCT04521647
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes

NCT04996940
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette product
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

NCT06554873
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 25, 2026, 9:12 AM EDT