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ClinicalTrials.gov public records Last synced Oct 18, 2026, 4:27 AM EDT

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Showing 265–288 of 374 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Methadone Clear all
Completed Not applicable Interventional

Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence

NCT05299515
View directory record Official record
Conditions
Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use, Opioid Addiction, Treatment Adherence, Retention in Care
Interventions
Peer-Delivered Behavioral Activation ("Peer Activate")
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland • College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Not applicable Interventional

A Study of Azidothymidine Plus Methadone in Patients With AIDS and AIDS Related Complex (ARC)

NCT00001008
View directory record Official record
Conditions
HIV Infections
Interventions
Methadone hydrochloride, Zidovudine
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 14, 2011 · Synced Oct 18, 2026, 4:27 AM EDT
Active, not recruiting No phase listed Observational

Methadone Perception Survey Study

NCT07537608
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Survey
Other
Lead sponsor
Ashley Smith
Other
Eligibility
Not listed
Enrollment
199 participants
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study on the Interaction Between Danoprevir/Ritonavir and Methadone

NCT01389544
View directory record Official record
Conditions
Healthy Volunteer
Interventions
danoprevir, methadone, ritonavir
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
2
States / cities
Anaheim, California • Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Oct 18, 2026, 4:27 AM EDT
Enrolling by invitation Phase 4 Interventional

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

NCT07365800
View directory record Official record
Conditions
Spine Surgery
Interventions
Methadone-dexmedetomidine-ketamine combination
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 79 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 18, 2026, 4:27 AM EDT
Withdrawn Not applicable Interventional

Development and Feasibility Testing of a Mobile Phone-Based HIV Primary Care Engagement Intervention

NCT02468544
View directory record Official record
Conditions
HIV, Adherence
Interventions
Text messaging
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 9, 2020 · Synced Oct 18, 2026, 4:27 AM EDT
Terminated Phase 2 Interventional

Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids

NCT01821430
View directory record Official record
Conditions
Chronic Pain
Interventions
Pregabalin, Placebo
Drug
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Not applicable Interventional Results available

Remote Methadone Ingestion Surveillance Trial (RMIST)

NCT05259501
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
RMIST
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Not applicable Interventional Results available

Comparison of Telemedicine to Usual Care for HCV Management for Methadone-maintained Individuals

NCT02933970
View directory record Official record
Conditions
Hepatitis C
Interventions
Telemedicine
Other
Lead sponsor
Andrew Talal
Other
Eligibility
18 Years and older
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 4 Interventional

Effects of Buspirone in Opiate Withdrawal

NCT00326235
View directory record Official record
Conditions
Heroin Dependence
Interventions
Buspirone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
25 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 4:27 AM EDT
Completed No phase listed Observational

Methadone Levels in Breast Milk of Women Taking Methadone for Opiate Addiction - 2

NCT00218010
View directory record Official record
Conditions
Breast Feeding, Opioid-Related Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 40 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 4:27 AM EDT
Recruiting Phase 2 Interventional

E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

NCT05722561
View directory record Official record
Conditions
Opioid Use Disorder, Cigarette Smoking
Interventions
Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
Behavioral · Drug · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 18, 2026, 4:27 AM EDT
Terminated Not applicable Interventional Results available

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

NCT01430182
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Oct 18, 2026, 4:27 AM EDT
Recruiting Phase 3 Interventional

Methadone in THA for Post-op Pain and Opioid Reduction

NCT07227064
View directory record Official record
Conditions
Post Operative Pain, Total Hip Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Not applicable Interventional Results available

The Effects of Minocycline in Opioid-maintained Patients

NCT02359006
View directory record Official record
Conditions
Opioid Dependence, Pain
Interventions
Minocycline, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Co-Administration Of Fosamprenavir With Methadone: A Drug Interaction Study.

NCT00481182
View directory record Official record
Conditions
Healthy Subjects
Interventions
fosamprenavir + ritonavir + methadone
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
2
States / cities
Baltimore, Maryland • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2009 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Not applicable Interventional

Automated Recovery Line for Medication Assisted Treatment

NCT02124980
View directory record Official record
Conditions
Drug Dependence, Substance Use Disorders
Interventions
Recovery Line
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 18, 2026, 4:27 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

TENS and Opioid Use After Cesarean Delivery

NCT03843788
View directory record Official record
Conditions
Cesarean Section Complications, Opioid Use
Interventions
Transcutaneous Electrical Nerve Stimulation (TENS)
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Testosterone Replacement for Male Opioid Agonist Maintained Patients

NCT01873989
View directory record Official record
Conditions
Chronic Pain, Opioid Addiction, Symptomatic Hypogonadism
Interventions
Testosterone replacement, Waitlist control
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 18, 2026, 4:27 AM EDT
Recruiting Phase 2 Interventional

Ketamine for Opioid Use Disorder

NCT06943859
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Treatment with Ketamine, Treatment with Very Low Dose Ketamine
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 2 Interventional

Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients - 1

NCT00000352
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
Dextromethorphan
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1998
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 4:27 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Intraoperative Methadone for Postoperative Pain Control After Thoracic Surgery

NCT04525898
View directory record Official record
Conditions
Postoperative Pain
Interventions
Methadone
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 21, 2021 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 2 Interventional

Study of Computer-Based Treatment for Drug Dependence

NCT01315184
View directory record Official record
Conditions
Opioid-Related Disorders, Heroin Dependence
Interventions
Recovery Line Support System
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Oct 18, 2026, 4:27 AM EDT
Completed Phase 3 Interventional

IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction

NCT01205256
View directory record Official record
Conditions
Scoliosis
Interventions
methadone
Drug
Lead sponsor
University of Virginia
Other
Eligibility
12 Years to 19 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 18, 2026, 4:27 AM EDT