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ClinicalTrials.gov public records Last synced Oct 23, 2026, 10:34 AM EDT

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Showing 529–552 of 1,015 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Microbiome Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Characterizing Skin Microbiome Change in Atopic Dermatitis

NCT04800185
View directory record Official record
Conditions
Atopic Dermatitis, Atopic Dermatitis Eczema
Interventions
Crisaborole 2% Top Oint, Skin Microbiome Swabs
Drug · Genetic
Lead sponsor
University of California, Irvine
Other
Eligibility
2 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2024 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Gut Butyrate and Blood Pressure in African Americans

NCT04415333
View directory record Official record
Conditions
Hypertension
Interventions
Sodium Butyrate 5 mmol, Sodium Butyrate 80 mmol
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
30 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Oct 23, 2026, 10:34 AM EDT
Withdrawn Phase 2 Interventional

Evaluation of the Kinetic Properties of an Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients

NCT02144142
View directory record Official record
Conditions
Atopic Dermatitis, Eczema
Interventions
Moisturizer with each subject's own antimicrobial bacteria
Biological
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 5, 2020 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of a Prebiotic Blend in Healthy Humans

NCT07514741
View directory record Official record
Conditions
Healthy Adult Participants
Interventions
Fiber Blend 1 (Low Dose), Fiber Blend 2 (High Dose), Placebo
Dietary Supplement · Other
Lead sponsor
LOAM Science
Other
Eligibility
18 Years to 60 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
West Hollywood, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Joint Microbiome Study for the Knee

NCT05254145
View directory record Official record
Conditions
Knee Osteoarthritis, PJI
Interventions
Next Generation Sequencing
Diagnostic Test
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 24, 2022 · Synced Oct 23, 2026, 10:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of an Oral Hair Supplement on Hair Density, Growth, and Microbiome

NCT06146166
View directory record Official record
Conditions
Hair Thinning
Interventions
Oral herbal supplement, Oral placebo supplement
Dietary Supplement
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
25 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Oct 23, 2026, 10:34 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Gastrointestinal Tract Microbiome in Healthy Term Infants Receiving Mother'S-own Breast Milk or Cow's Milk-based Infant Formulas

NCT04059666
View directory record Official record
Conditions
Gastrointestinal Microbiome
Interventions
Investigational, Control
Other
Lead sponsor
Mead Johnson Nutrition
Industry
Eligibility
7 Days to 18 Days
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
5
States / cities
Birmingham, Alabama • Altamonte Springs, Florida • Owensboro, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Oct 23, 2026, 10:34 AM EDT
Recruiting Not applicable Interventional

Effects of Pomegranate Juice on Ulcerative Colitis

NCT07115862
View directory record Official record
Conditions
Ulcerative Colitis (Disorder)
Interventions
pomegranate juice -> habitual diet, habitual diet -> pomegranate juice
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Controlled Trial Investigating if Antibiotic Use in the First 48 Hours of Life Adversely Impacts the Preterm Infant Microbiome

NCT02477423
View directory record Official record
Conditions
Premature Birth of Newborn, Enterocolitis, Necrotizing
Interventions
Ampicillin, Gentamicins, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
Up to 6 Hours
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 23, 2026, 10:34 AM EDT
Recruiting Not applicable Interventional

Prebiotic Food-enriched Diet (PreFED) to Enhance the Microbiome and Response to First-line Immunotherapy in Unresectable Melanoma

NCT06466434
View directory record Official record
Conditions
Unresectable Melanoma
Interventions
Prebiotic Food-Enriched Diet
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Exercise & Tart Cherry Ingestion on Heat Acclimation and Gut Microbiome

NCT05281198
View directory record Official record
Conditions
Heat Acclimation and Thermotolerance
Interventions
tart cherry juice, Placebo
Dietary Supplement
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Oct 23, 2026, 10:34 AM EDT
Recruiting Not applicable Interventional

The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies

NCT06072976
View directory record Official record
Conditions
Gastrointestinal Complication, Intestinal Obstruction, Gastroschisis, Hirschsprung Disease, Omphalocele, Midgut Volvulus
Interventions
Standard of Care, Exclusive Human Milk
Dietary Supplement
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
0 Days to 55 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Recruiting Not applicable Interventional

Effects of Grape Consumption on the Immune-Gut Axis in Obesity

NCT07231484
View directory record Official record
Conditions
Obesity &Amp; Overweight
Interventions
Freeze-dried grape powder, Placebo powder
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults

NCT05387876
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Vitamin D intervention, Placebo intervention
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 79 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Oct 23, 2026, 10:34 AM EDT
Enrolling by invitation Not applicable Interventional

Glycemic Impact of NNS Via the Gut Microbiome

NCT07868432
View directory record Official record
Conditions
Prediabetes
Interventions
Sucralose
Dietary Supplement
Lead sponsor
Tufts University
Other
Eligibility
35 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Completed No phase listed Observational

Environmental Health Effects on Your Physiology

NCT03986814
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 25 Years
Enrollment
92 participants
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Antimicrobial-free Production of Beef Cattle's Affect on Gut Microbiome

NCT04023604
View directory record Official record
Conditions
Diet Modification
Interventions
Controlled diet with beef raised without antibiotics, Controlled diet with beef produced in conventional systems
Other
Lead sponsor
Purdue University
Other
Eligibility
21 Years to 69 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial

NCT04079218
View directory record Official record
Conditions
HIV Infection, Vaginal Atrophy, Menopause, Menopause Related Conditions, Aging, Premature Aging, Atrophic Vaginitis, Dysbiosis, Vaginitis
Interventions
Estradiol Vaginal Insert
Drug
Lead sponsor
Kerry Murphy
Other
Eligibility
45 Years to 70 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 14, 2025 · Synced Oct 23, 2026, 10:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Microbiome and the Gut-Brain Axis

NCT02693327
View directory record Official record
Conditions
Mental Disorder
Interventions
Biological Sample, Blood Sample
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumption

NCT06724705
View directory record Official record
Conditions
Lactose Intolerance, Adult Type
Interventions
Lactose, Sucrose, Wear smart underwear
Dietary Supplement · Device
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lean and Obese: Dietary Inflammation

NCT05327868
View directory record Official record
Conditions
Obesity, Inflammation, Dietary Fat
Interventions
Low Fat Diet (LFD), High Fat Diet (HFD)
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
50 Years to 79 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wheat Germ Supplementation Will Improve Markers of Gut Health, Inflammation, and Insulin Resistance in Overweight Adults

NCT03989882
View directory record Official record
Conditions
Overweight, Insulin Resistance, Inflammation
Interventions
Wheat germ energy ball, Control
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Oct 23, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Pre-, Pro- & Anti-biotics on Gut Microbiota

NCT01414010
View directory record Official record
Conditions
Human Gut Microbiota
Interventions
Trametes versicolor extract, Saccharomyces boulardii, Amoxicillin
Dietary Supplement · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 23, 2026, 10:34 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms

NCT06607523
View directory record Official record
Conditions
Brain Injuries
Interventions
Inulin
Dietary Supplement
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 23, 2026, 10:34 AM EDT