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ClinicalTrials.gov public records Last synced Oct 23, 2026, 7:16 PM EDT

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Showing 577–600 of 1,015 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Microbiome Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Microbiome Effect of Omadacycline on Healthy Volunteers

NCT06030219
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Omadacycline, Vancomycin Pill, Moxifloxacin
Drug
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 40 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Oct 23, 2026, 7:16 PM EDT
Completed Phase 3 Interventional Results available

ECOSPOR IV: An Open-Label Study Evaluating SER-109 in Recurrent Clostridioides Difficile Infection

NCT03183141
View directory record Official record
Conditions
Clostridioides Difficile Infection
Interventions
SER-109
Biological
Lead sponsor
Seres Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
97
States / cities
Dothan, Alabama • Sun City West, Arizona • Mather, California + 84 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2023 · Synced Oct 23, 2026, 7:16 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Gestational Diabetes Mellitus (GDM) in Pregnant Women

NCT05265741
View directory record Official record
Conditions
Gestational Diabetes Mellitus, Pregnancy Complications
Interventions
Not listed
Lead sponsor
Long Island University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Oct 23, 2026, 7:16 PM EDT
Completed No phase listed Observational

Effect of Radiotherapy Variables on Circulating Effectors of Immune Response and Local Microbiome

NCT03383107
View directory record Official record
Conditions
Breast Cancer, Prostate Cancer
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 90 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 12, 2022 · Synced Oct 23, 2026, 7:16 PM EDT
Enrolling by invitation Not applicable Interventional

Microbiome Effects of Extended Use of MI Paste in Elderly Removable Denture Wearers

NCT06406751
View directory record Official record
Conditions
Dental Prosthesis
Interventions
MI Paste
Device
Lead sponsor
University of Iowa
Other
Eligibility
65 Years to 105 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 23, 2026, 7:16 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease

NCT03850600
View directory record Official record
Conditions
Crohn Disease, Pregnancy
Interventions
Diet-CD
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
2
States / cities
Worcester, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Oct 23, 2026, 7:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer

NCT03304132
View directory record Official record
Conditions
Oral Cancer
Interventions
Classification of Oral Microbiome Using 16S rRNA gene sequence-based approach, Classification of Oral Microbiome Using taxonomic approach
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 92 Years
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2017 · Synced Oct 23, 2026, 7:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Alcohol and Cannabis Co-Use and the Gut-Brain Axis

NCT04998006
View directory record Official record
Conditions
Cannabis Use, Alcohol Use, Inflammation
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 60 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Obesity Observational Prospective Trial

NCT03139877
View directory record Official record
Conditions
Pediatric Obesity
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
10 Years to 18 Years
Enrollment
295 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 23, 2026, 7:16 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)

NCT04867512
View directory record Official record
Conditions
Small Intestinal Bacterial Overgrowth (SIBO)
Interventions
Liquid Tincture, GI Detox, Olivirex
Dietary Supplement
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
18 Years to 60 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Oct 23, 2026, 7:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Acne Vulgaris Related Microbiology and Serology

NCT04056598
View directory record Official record
Conditions
Acne Vulgaris
Interventions
Study of humoral immunity
Diagnostic Test
Lead sponsor
Sanofi
Industry
Eligibility
18 Years to 40 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Oct 23, 2026, 7:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Meals Study for Amyotrophic Lateral Sclerosis and Parkinson's Disease

NCT07625605
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease (PD)
Interventions
The MIND diet
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
30 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
3
States / cities
Elizabethton, Tennessee • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Recruiting Phase 1Phase 2 Interventional

Snacks and Brain Health

NCT07348406
View directory record Official record
Conditions
Cognitive Assessment, Psychological Function, GI Health
Interventions
Pecan snack, Pretzel snack
Biological
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility

NCT03401918
View directory record Official record
Conditions
Recurrent Pregnancy Loss, Unexplained Infertility
Interventions
Uterine ERA and microbiome testing, Oral antibiotics and vaginal probiotics
Diagnostic Test · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Oct 23, 2026, 7:16 PM EDT
Recruiting No phase listed Observational

Intestinal Microbiota in Stem Cell Transplant Transplant Admission

NCT04623424
View directory record Official record
Conditions
Stem Cell Transplant Complications
Interventions
intestinal microbiota
Diagnostic Test
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Completed No phase listed Observational

Evaluation of Vaginal Microbiome as a Biomarker for the Improvement of Vaginal Health in Women With Breast Cancer, ARISE Study

NCT05946668
View directory record Official record
Conditions
Breast Neoplasms
Interventions
Biospecimen Collection, Electronic Health Record Review, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Recruiting Not applicable Interventional

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

NCT05136703
View directory record Official record
Conditions
Depression, HIV-1-infection, Inflammation
Interventions
Cognitive-Behavioral Therapy for Adherence and Depression (CBT-AD), Antiretroviral Therapy (ART) Adherence Counseling
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Coral Gables, Florida • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Recruiting Early Phase 1 Interventional

Probiotic Administration for Adolescent Depression

NCT06898788
View directory record Official record
Conditions
Depression
Interventions
Visbiome, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
15 Years to 24 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Freeze Dried Strawberry Powder Supplementation on Cardiovascular Risk Factors and Gut Microbiome

NCT03522974
View directory record Official record
Conditions
Cardiovascular Risk Factor
Interventions
Strawberry powder, Placebo powder
Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
30 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 23, 2026, 7:16 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Salt and Gut Study

NCT04958148
View directory record Official record
Conditions
High Blood Pressure
Interventions
Salt pills, Placebo pills
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Oct 23, 2026, 7:16 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.

NCT02806414
View directory record Official record
Conditions
Rosacea
Interventions
Ivermectin
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 23, 2026, 7:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healthy Patients & Effect of Antibiotics

NCT03098485
View directory record Official record
Conditions
Microbiota, Anti-bacterial Agents
Interventions
Levofloxacin, Azithromycin, Cefpodoxime
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 10, 2022 · Synced Oct 23, 2026, 7:16 PM EDT
Recruiting No phase listed Observational

Avera Cancer Sequencing and Analytics Protocol (ASAP)

NCT05142033
View directory record Official record
Conditions
Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer, Lung Cancer, Colon Cancer, GI Cancer, Gynecologic Cancer, Ovarian Cancer, Endometrial Cancer, CNS Cancer, Hematologic Cancer
Interventions
Not listed
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
25,000 participants
Timeline
2021 – 2026
U.S. locations
6
States / cities
Marshall, Minnesota • Aberdeen, South Dakota • Mitchell, South Dakota + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 23, 2026, 7:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles

NCT03611647
View directory record Official record
Conditions
Pregnancy Related
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
3
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 23, 2026, 7:16 PM EDT